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Reciprocal Interareal Connections to Corticospinal Neurons in Mouse M1 and S2 Open Access (recommended)

Descriptions

Resource type(s)
Journal Article
Keyword
Neuroscience
Neocortex
Rights
Attribution 3.0 United States

Creator
Suter, Benjamin
Shepherd, Gordon M. G.
Abstract
Primary motor (M1) and secondary somatosensory (S2) cortices, although anatomically and functionally distinct, share an intriguing cellular component: corticospinal neurons (CSP) in layer 5B. Here, we investigated the long-range circuits of CSPs in mouse forelimb-M1 and S2. We found that interareal projections (S2 M1 and M1 S2) monosynaptically excited pyramidal neurons across multiple layers, including CSPs. Area-specific differences were observed in the relative strengths of inputs to subsets of CSPs and other cell types, but the general patterns were similar. Furthermore, subcellular mapping of the dendritic distributions of these corticocortical excitatory synapses onto CSPs in both areas also showed similar patterns. Because layer 5B is particularly thick in M1, but not S2, we studied M1-CSPs at different cortical depths, quantifying their dendritic morphology and mapping inputs from additional cortical (M2, contralateral M1, and local layer 2/3) and thalamic (VL nucleus) sources. These results indicated that CSPs exhibit area-specific modifications on an otherwise conserved synaptic organization, and that different afferents innervate M1-CSP dendritic domains in a source-specific manner. In the cervical spinal cord, CSP axons from S2 and M1 partly converged on middle layers, but S2-CSP axons extended further dorsally, and M1-CSP axons ventrally. Thus, our findings identify many shared features in the circuits of M1 and S2 and show that these areas communicate via mutual projections that give each area monosynaptic access to the other area's CSPs. These interareally yoked CSP circuits may enable M1 and S2 to operate in a coordinated yet differentiated manner in the service of sensorimotor integration.
Original Bibliographic Citation
Suter, Benjamin A., Shepherd, Gordon M.G. (2015) Reciprocal Interareal Connections to Corticospinal Neurons in Mouse M1 and S2. J Neurosci 35:2959-2974.
Related URL
Publisher
The Journal of Neuroscience
DigitalHub. Galter Health Sciences Library
Date Created
2015
Original Identifier
(PMID)25698734
Language
English
Subject: MESH
Brain Mapping
Luminescent Proteins
Mice, Inbred C57BL
Mice, Transgenic
Motor Cortex
Neural Pathways
Pyramidal Tracts
Somatosensory Cortex
Synapses
Thalamus
DOI
10.1523/JNEUROSCI.4287-14.2015
ARK
ark:/c8131/g3g01j

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