Published January 27, 2021 | Version v1.0.0
Journal Article Open

Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury

  • 1. ROR icon Guangdong Medical College
  • 2. ROR icon University of Illinois at Chicago
  • 3. ROR icon Northwestern University

Abstract

The cytokine storm or cytokine storm syndrome (CSS) is associated with high mortality in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), for example following sepsis or infectious diseases including COVID-19. However, there are no effective treatments for CSS-associated ALI or ALI/ARDS. Thus, there remains an urgent need to develop effective drugs and therapeutic strategies against CSS and ALI/ARDS. Nasal and inhaled drug delivery methods represent a promising strategy in the treatment of inflammatory lung disease as a result of their ability to improve drug delivery to lungs. Improving the nasal mucosa absorption of poorly water-soluble drugs with poor mucosa bioavailability to a therapeutically effective level is another promising strategy in the fight against ALI/ARDS. Here, chitosan nanoparticles loaded with hesperidin (HPD/NPs) were developed for nasal delivery of the anti-inflammatory HPD compound to inflammatory lungs. In vitro and in vivo, HPD/NPs exhibited enhanced cellular uptake in the inflammatory microenvironment compared with free HPD. In a mouse model of inflammatory lung disease, the HPD/NPs markedly inhibited lung injury as evidenced by reduced inflammatory cytokine levels and suppressed vascular permeability compared with free HPD. Collectively, our study demonstrates that nasal delivery of HPD/NPs suppresses CSS and ALI/ARDS in a murine model of inflammatory lung disease, and that nanoparticle-based treatment strategies with anti-inflammatory effects could be used to reduce CSS and ALI in patients with inflammatory lung injury.

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original_citation: Jin H, Zhao ZG, Lan Q, Zhou HT, Mai ZS, Wang Y, Ding XW, Zhang WT, Pi J, Evans CE, Liu XG. Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury. Frontiers in Pharmacology. 2021;11:10.

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Nasal Delivery of HesperidinChitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury.pdf

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Funding

The regulation of small glue cell polarization of intestinal functional flora in the short -chain fatty acids in Parkinson's disease and the research of its mechanism 81971329
National Natural Science Foundation of China
The role of PCK1 protein in aging process and its molecular mechanism 81671399
National Natural Science Foundation of China
Award number pdjh2019b0224 pdjh2019b0224
Special Funds for the Cultivation of Guangdong College Students' Scientific, Technological Innovation (Climbing Program Special Funds)
Award number B2019012 B2019012
Guangdong Medical College
Award number 4SG19057G 4SG19057G
Special Supporting Project for Educational Talents in Universities
Novel Regulation of Sepsis-Induced Lung Injury by Pulmonary Thrombosis 19CDA34500000
American Heart Association

Dates

Created
2021-01-27
When the item was originally created.