Collections

This file is in the following collections:

A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care Open Access (recommended)

Descriptions

Resource type(s)

Review

Keyword

SARS-CoV-2
COVID-19
circadian clock
critical care
nutrition
zeitgeber
rhythm

Rights

Attribution 4.0 International

Creator

Haspel, Jeffrey
Kim, Minjee
Zee, Phyllis C
Schwarzmeier, Tanja
Montagnese, Sara
Panda, Satchidananda
Albani, Adriana
Merrow, Martha

Abstract

We currently find ourselves in the midst of a global coronavirus disease 2019 (COVID-19) pandemic, caused by the highly infectious novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we discuss aspects of SARS-CoV-2 biology and pathology and how these might interact with the circadian clock of the host. We further focus on the severe manifestation of the illness, leading to hospitalization in an intensive care unit. The most common severe complications of COVID-19 relate to clock-regulated human physiology. We speculate on how the pandemic might be used to gain insights on the circadian clock but, more importantly, on how knowledge of the circadian clock might be used to mitigate the disease expression and the clinical course of COVID-19.

Original Bibliographic Citation

Haspel J, Kim M, Zee P, Schwarzmeier T, Montagnese S, Panda S, Albani A, Merrow M. A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care. Journal of Biological Rhythms. 2021;36(1):55-70.

Related URL

 https://journals.sagepub.com/doi/10.1177/0748730421992587

Publisher

SAGE PUBLICATIONS INC

Date Created

2021-02

Original Identifier

(PMID) 33573430

Language

English

Subject: MESH

SARS-CoV-2
Circadian Clocks
Circadian Rhythm
COVID-19

Subject: LCSH

COVID-19 (Disease)
Circadian rhythms

Acknowledgments

We are grateful for the participation of so many colleagues in the European Biological Rhythms Society (EBRS) Workshop Chonobiology of COVID-19. The open discussion helped us to solidify our ideas and concepts for how chronobiology could intersect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) biology and COVID-19 severe illness. The work of M.M. is supported by the Volkswagen Foundation (Life? Funding Program: The Fourth Dimension) and by the Friedrich Bauer Stiftung and the Verein zur Forderung von Wissenschaft und Forschung of the LMU Munich. The work of A.A. is supported by the Munich Excellence Training Initiative for Physician Scientists (Metiphys) program of the LMU Munich. The work of T.S. is supported by the Frderprogramm fr Forschung und Lehre (FFoLe) of the LMU Munich

Grants and funding

Volkswagen Foundation (Life? Funding Program: The Fourth Dimension); Friedrich Bauer Stiftung; Verein zur Forderung von Wissenschaft und Forschung of the LMU Munich; Munich Excellence Training Initiative for Physician Scientists (Metiphys) program of the LMU Munich; Forderprogramm fur Forschung und Lehre (FoFoLe) of the LMU Munich

DOI

10.1177/0748730421992587

File Details

File Properties

Mime type: application/pdf

File size: 433.1 kB