Thrombotic microangiopathy in the cancer patient

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Resource type(s): Article
Keyword: hematology
Rights: Attribution 4.0 International
Creator: Kwaan, Hau C
Gordon, Leo I
Abstract: Thrombotic microangiopathy, manifesting as thrombotic thrombocytopenic purpura (TTP) or hemolytic uremic syndrome, is a common complication in cancer patients. It shares the pathogenic microvascular occlusive lesion and many clinical manifestations as the classical TTP, but the spectrum of complications varies widely. Several subsets are seen, including a microangiopathic hemolyticanemia in advanced cancer, chemotherapeutic drug-associated microangiopathy and those with the transplant setting. The prognosis is not as favorable as in classical TTP. Anecdotal reports indicate that responses are seen with plasma exchange and with immunoadsorption.
Original Bibliographic Citation: Kwaan, H. C., & Gordon, L. I. (2001). Thrombotic microangiopathy in the cancer patient. Acta Haematol, 106(1-2), 52-56. https://doi.org/10.1159/000046589
Publisher: DigitalHub. Galter Health Sciences Library
Date Created: 2001
Original Identifier: (PMID) 11549777
Language: English
Subject: MESH: Thrombotic Microangiopathies
Purpura, Thrombotic Thrombocytopenic
Neoplasms
Hemolytic-Uremic Syndrome
DOI: 10.1159/000046589
10.18131/G3GG68
ARK: ark:/c8131/g3gg68