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Respiratory Microbial Co-infection With SARS-CoV-2 Open Access (recommended)

Descriptions

Resource type(s)

Article

Keyword

COVID-19
SARS-CoV-2
respiratory co-infection
K. pneumoniae
M. catarrhalis
nursing home
age
race

Rights

Attribution 4.0 International

Creator

Massey, Bill W
Jayathilake, Karu
Meltzer, Herbert Y

Abstract

Co-infection with additional pathogens is a well-known feature of pandemics. We determined the prevalence and type of a wide variety of respiratory pathogens in 12,075 United States subjects tested for SARS-CoV-2 infection in March and April 2020. Infections with other respiratory pathogens, which on their own produce at least some SARS-CoV-2 symptoms including mortality, were present in both SARS-CoV-2 + and SARS-CoV-2- subjects. Non-SARS-CoV-2 infection rates were significantly higher in SARS-CoV-2 + (86%) patients than SARS-CoV-2- patients (76%) (p< 0.0001). Among the co-pathogens present in both subject groups were K. pneumoniae and M. catarrhalis which can produce serious respiratory illness on their own, Advanced age and nursing home status were associated with higher SARS-CoV-2 + and co-infection rates. Testing for the presence of co-pathogens going forward will assist in the diagnosis and optimal treatment of suspected SARS-CoV-2 respiratory infections in the current pandemic.

Original Bibliographic Citation

Massey BW, Jayathilake K, Meltzer HY. Respiratory Microbial Co-infection With SARS-CoV-2. Frontiers in Microbiology. 2020;11:7.

Related URL

 https://www.frontiersin.org/articles/10.3389/fmicb.2020.02079/full

Publisher

FRONTIERS MEDIA SA

Date Created

2020-08-25

Original Identifier

(PMID) 32983056

Language

English

Subject: MESH

COVID-19
SARS-CoV-2
Coinfection
Klebsiella pneumoniae
Moraxella catarrhalis
Health Services for the Aged
Nursing Homes

Acknowledgments

The authors would like to acknowledge Vikor Scientific LLC for the use of their database. The authors would also like to acknowledge Tony Donofrio and Kevin Yee of Ovation.io Inc. for creation of the data query engine and data acquisition, and Robin Prince for antimicrobial treatment recommendations.

Grants and funding

This study was supported, in part, by a donation from the Weisman family.

DOI

10.3389/fmicb.2020.02079

File Details

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Mime type: application/pdf

File size: 174.9 kB