DNA Methylation of Individual Repetitive Elements in Hepatitis C Virus Infection-Induced Hepatocellular Carcinoma Open Access (recommended)
The two most common repetitive elements (REs) in humans, long interspersed nuclear element-1 (LINE-1) and Alu element (Alu), have been linked to various cancers. Hepatitis C virus (HCV) may cause hepatocellular carcinoma (HCC) by suppressing host defenses, through DNA methylation that controls the mobilization of REs. We aimed to investigate the role of RE methylation in HCV-induced HCC (HCV-HCC).
Descriptions
- Resource type(s)
- Journal Article
- Keyword
- Hepatitis C Virus
Hepatocellular Carcinoma
DNA Methylation
Repetitive Element
- Rights
- Attribution-NonCommercial-ShareAlike 3.0 United States
- Creator
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Zheng, Yinan
Hlady, Ryan A.
Joyce, Brian
Robertson, Keith D.
He, Chunyan
Nannini, Drew R.
Kibbe, Warren A.
Achenbach, Chad J
Murphy, Robert Leo
Roberts, Lewis R.
Hou, Lifang
- Publisher
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DigitalHub. Galter Health Sciences Library & Learning Center
- Date Created
-
2019
- Language
- English
- Subject: MESH
-
Carcinoma, Hepatocellular
Hepatitis C
DNA Methylation
- Grants and funding
-
Research reported in this publication was supported by the Fogarty International Center of the National Institutes of Health under Award Number D43TW009575 (RLM and LH) and U54CA221205 (LH and RLM), AASLD Clinical and Translational Research Award in Liver Diseases (RAH), and R01DK110024 and R01AA027179 (KDR). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- DOI
-
10.18131/g3-thm5-d910
File Details
- File Properties
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