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Motor Cortex Microcircuit Simulation Based on Brain Activity Mapping Open Access (recommended)

Descriptions

Resource type(s)

Journal Article

Keyword

Neuroscience
Neocortex

Rights

Attribution 3.0 United States

Creator

Suter, Benjamin
Chadderdon, George L
Shepherd, Gordon M G

Abstract

The deceptively simple laminar structure of neocortex belies the complexity of intra- and interlaminar connectivity. We developed a computational model based primarily on a unified set of brain activity mapping studies of mouse M1. The simulation consisted of 775 spiking neurons of 10 cell types with detailed population-to-population connectivity. Static analysis of connectivity with graph-theoretic tools revealed that the corticostriatal population showed strong centrality, suggesting that would provide a network hub. Subsequent dynamical analysis confirmed this observation, in addition to revealing network dynamics that cannot be readily predicted through analysis of the wiring diagram alone. Activation thresholds depended on the stimulated layer. Low stimulation produced transient activation, while stronger activation produced sustained oscillations where the threshold for sustained responses varied by layer: 13% in layer 2/3, 54% in layer 5A, 25% in layer 5B, and 17% in layer 6. The frequency and phase of the resulting oscillation also depended on stimulation layer. By demonstrating the effectiveness of combined static and dynamic analysis, our results show how static brain maps can be related to the results of brain activity mapping.

Original Bibliographic Citation

Chadderdon GL, Mohan A, Suter BA, Neymotin SA, Kerr CC, Francis JT, Shepherd GM, Lytton WW. (2014) Motor Cortex Microcircuit Simulation Based on Brain Activity Mapping. Neural Comput. 26(7):1239-1262.

Related URL

 http://www.mitpressjournals.org/doi/full/10.1162/NECO_a_00602

Publisher

Massachusetts Institute of Technology
DigitalHub. Galter Health Sciences Library

Date Created

2013

Original Identifier

(PMID)24708371

Language

English

Subject: MESH

Brain Mapping
Mice
Computer Simulation
Models, Neurological
Motor Cortex
Neural Pathways
Neurons
Periodicity
Synapses

DOI

10.1162/NECO_a_00602

ARK

ark:/c8131/g30016

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