Recent advances in gene therapy for atrial fibrillation

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Resource type(s): Journal Article
Keyword: Gene Therapy
Atrial Fibrillation
Creator: Rottmann, Markus
Yoo, Shin
Geist, Gail Elizabeth
Pfenniger, Anna
Arora, Rishi K
Abstract: Atrial fibrillation (AF) is the most common heart rhythm disorder in adults and a major cause of stroke. Unfortunately, current treatments for AF are suboptimal as they are not targeting the molecular mechanisms underlying AF. In this regard, gene therapy is emerging as a promising approach for mechanismbased treatment of AF. In this review, we summarize recent advances and challenges in gene therapy for this important cardiovascular disease.
Original Bibliographic Citation: Yoo S, Geist GE, Pfenniger A, Rottman M, Arora R. Recent advances in gene therapy for atrial fibrillation. J Cardiovasc Electrophysiol. 2021;32:28542864.
Publisher: Journal of Cardiovascular Electrophysiology
DigitalHub. Galter Health Sciences Library & Learning Center
Date Created: 2021-05-30
Original Identifier: (DOI) 10.1111/jce.15116
Language: English
Subject: MESH: Atrial Fibrillation
Genetic Therapy
Grants and funding: AHA Strategically Focused Research Networks AF Center grant; NIH Center for Accelerated Innovations at Cleveland Clinic (NCAICC); National Heart, Lung, and Blood Institute, Grant/Award Numbers: RA: R01 HL093490, R01 HL140061
DOI: 10.1111/jce.15116