Ticlopidine-, Clopidogrel-, and Prasugrel-associated thrombotic thrombocytopenic purpura: a 20-year review from the Southern Network on Adverse Reactions (SOAR) Open Access (recommended)
Descriptions
- Resource type(s)
- Article
- Keyword
- Ticlopidine
Clopidogrel
Prasugrel
- Rights
- Attribution 4.0 International
- Creator
-
Jacob, Sony
Dunn, Brianne L.
Qureshi, Zaina, 1982-
Bandarenko, Nicholas
Kwaan, Hau C
Pandey, Dilip K.
McKoy, June M
Barnato, Sara E.
Winters, Jeffrey L.
Cursio, John F.
Weiss, Ivy M
Raife, Thomas J.
Carey, Patricia M.
Sarode, Ravindra
Kiss, Joseph E.
Danielson, Constance
Ortel, Thomas L. (Thomas Lee), 1957-
Clark, William F.
Rock, Gail
Matsumoto, Masanori, 1935-
Fujimura, Yoshihiro
Zheng, X. Long
Chen, Hao
Chen, Fei
Armstrong, John M.
Raisch, Dennis W.
Bennet, Charles L.
- Abstract
-
Thienopyridine derivatives (ticlopidine, clopidogrel, and prasugrel) are the primary antiplatelet agents. Thrombotic thrombocytopenic purpura (TTP) is a rare drug-associated syndrome, with the thienopyridines being the most common drugs implicated in this syndrome. We reviewed 20 years of information on clinical, epidemiologic, and laboratory findings for thienopyridine-associated TTP. Four, 11, and 11 cases of thienopyridine- associated TTP were reported in the first year of marketing of ticlopidine (1989), clopidogrel (1998), and prasugrel (2010), respectively. As of 2011, the FDA received reports of 97 ticlopidine-, 197 clopidogrel-, and 14 prasugrel-associated TTP cases. Severe deficiency of ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13) was present in 80% and antibodies to 100% of these TTP patients on ticlopidine, 0% of the patients with clopidogrel-associated TTP (p < 0.05), and an unknown percentage of patients with prasugrel-associated TTP. TTP is associated with use of each of the three thienopyridines, although the mechanistic pathways may differ.
- Original Bibliographic Citation
-
Jacob, S., Dunn, B. L., Qureshi, Z. P., Bandarenko, N., Kwaan, H. C., Pandey, D. K., . . . Bennett, C. L. (2012). Ticlopidine-, clopidogrel-, and prasugrel-associated thrombotic thrombocytopenic purpura: a 20-year review from the Southern Network on Adverse Reactions (SONAR). Semin Thromb Hemost, 38(8), 845-853. doi:10.1055/s-0032-1328894
- Publisher
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Thieme Medical Publishers, Inc.
DigitalHub. Galter Health Sciences Library
- Date Created
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2012-10-30
- Original Identifier
- (PMID) 23111862
- Language
- English
- Subject: MESH
-
Ticlopidine
Purpura, Thrombotic Thrombocytopenic
Thienopyridines
- DOI
-
10.1055/s-0032-1328894
- ARK
-
ark:/c8131/g3bk5p
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