Collections

This file is in the following collections:

Factors Associated With Intubation and Prolonged Intubation in Hospitalized Patients With COVID-19 Open Access (recommended)

Descriptions

Resource type(s)

Article

Keyword

COVID-19
SARS-CoV-2
coronavirus
hospitalized
adults
mechanical ventilator
intubation
tracheostomy

Rights

Attribution 4.0 International

Creator

Hur, Kevin
Price, Caroline P E
Gray, Elizabeth Lucia
Gulati, Reeti Kiran
Maksimoski, Matthew Thomas
Racette, Samuel David
Schneider, Alexander Louis
Khanwalkar, Ashoke R

Abstract

Objective To identify risk factors associated with intubation and time to extubation in hospitalized patients with coronavirus disease 2019 (COVID-19). Study Design Retrospective observational study. Setting Ten hospitals in the Chicago metropolitan area. Subjects and Methods Patients with laboratory-confirmed COVID-19 admitted between March 1 and April 8, 2020, were included. We evaluated sociodemographic and clinical characteristics associated with intubation and prolonged intubation for acute respiratory failure secondary to COVID-19 infection. Results Of the 486 hospitalized patients included in the study, the median age was 59 years (interquartile range, 47-69); 271 (55.8%) were male; and the median body mass index was 30.6 (interquartile range, 26.5-35.6). During the hospitalization, 138 (28.4%) patients were intubated; 78 (56.5%) were eventually extubated; 21 (15.2%) died; and 39 (28.3%) remained intubated at a mean +/- SD follow-up of 19.6 +/- 6.7 days. Intubated patients had a significantly higher median age (65 vs 57 years, P < .001) and rate of diabetes (56 [40.6%] vs 104 [29.9%], P = .031) as compared with nonintubated patients. Multivariable logistic regression analysis identified age, sex, respiratory rate, oxygen saturation, history of diabetes, and shortness of breath as factors predictive of intubation. Age and body mass index were the only factors independently associated with time to extubation. Conclusion In addition to clinical signs of respiratory distress, patients with COVID-19 who are older, male, or diabetic are at higher risk of requiring intubation. Among intubated patients, older and more obese patients are at higher risk for prolonged intubation. Otolaryngologists consulted for airway management should consider these factors in their decision making.

Original Bibliographic Citation

Hur K, Price CPE, Gray EL, Gulati RK, Maksimoski M, Racette SD, Schneider AL, Khanwalkar AR. Factors Associated With Intubation and Prolonged Intubation in Hospitalized Patients With COVID-19. Otolaryngology-Head and Neck Surgery. 2020;163(1):170-178.

Related URL

 https://journals.sagepub.com/doi/10.1177/0194599820929640

Publisher

SAGE PUBLICATIONS INC

Date Created

2020-07

Original Identifier

(PMID) 32423368

Language

English

Subject: MESH

COVID-19
SARS-CoV-2
Hospitalization
Intubation
Tracheostomy
Ventilators, Mechanical

Subject: Geographic Name

Illinois--Chicago

Grants and funding

Northwestern University Clinical and Translational Sciences Institute (National Institutes of Health) [UL1TR001422]

DOI

10.1177/0194599820929640

File Details

File Properties

Mime type: application/pdf

File size: 1008.7 kB