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Gender-specificity of resilience in major depressive disorder Open Access (recommended)

Descriptions

Resource type(s)

Article

Keyword

depression
major depressive disorder
resilience
resilient
SARS-CoV2
survey

Rights

Attribution-NonCommercial-NoDerivs 3.0 United States

Creator

Perlis, Roy H.
Ognyanova, Katherine
Quintana, Alexi
Green, Jon
Santillana, Mauricio
Lin, Jennifer
Druckman, James N
Lazer, David
Simonson, Matthew D.
Baum, Matthew A.
Chwe, Hanyu

Abstract

Introduction The major stressors associated with the COVID-19 pandemic provide an opportunity to understand the extent to which protective factors against depression may exhibit gender-specificity. Method This study examined responses from multiple waves of a 50 states non-probability internet survey conducted between May 2020 and January 2021. Participants completed the PHQ-9 as a measure of depression, as well as items characterizing social supports. We used logistic regression models with population reweighting to examine association between absence of even mild depressive symptoms and sociodemographic features and social supports, with interaction terms and stratification used to investigate sex-specificity. Results Among 73,917 survey respondents, 31,199 (42.2%) reported absence of mild or greater depression-11,011/23,682 males (46.5%) and 20,188/50,235 (40.2%) females. In a regression model, features associated with greater likelihood of depression-resistance included at least weekly attendance of religious services (odds ratio [OR]: 1.10, 95% confidence interval [CI]: 1.04-1.16) and greater trust in others (OR: 1.04 for a 2-unit increase, 95% CI: 1.02-1.06), along with level of social support measured as number of social ties available who could provide care (OR: 1.05, 95% CI: 1.02-1.07), talk to them (OR: 1.10, 95% CI: 1.07-1.12), and help with employment (OR: 1.06, 95% CI: 1.04-1.08). The first two features showed significant interaction with gender (p < .0001), with markedly greater protective effects among women. Conclusion Aspects of social support are associated with diminished risk of major depressive symptoms, with greater effects of religious service attendance and trust in others observed among women than men.

Original Bibliographic Citation

Perlis RH, Ognyanova K, Quintana A, Green J, Santillana M, Lin JN, Druckman J, Lazer D, Simonson MD, Baum MA, Chwe HY. Gender-specificity of resilience in major depressive disorder. Depression and Anxiety. 2021;38(10):1026-1033.

Related URL

 https://onlinelibrary.wiley.com/doi/10.1002/da.23203

Publisher

WILEY

Date Created

2021-08-09

Original Identifier

(PMID) 34370885

Language

English

Subject: MESH

Gender Identity
COVID-19
Depressive Disorder, Major
Depressive Disorder
Resilience, Psychological

Grants and funding

National Institute of Mental Health, Grant/Award Numbers: 1R56MH115187, R01MH116270; National Science Foundation, Grant/Award Numbers: SES2029292, SES2029792

DOI

10.1002/da.23203

File Details

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Mime type: application/pdf

File size: 474.3 kB