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- Title:
- Comparison of range-of-motion and variability in upper body movements between transradial prosthesis users and able-bodied controls when executing goal-oriented tasks
- Original Bibliographic Citation:
- Major MJ, Stine RL, Heckathorne CW, Fatone S, Gard SA. (2014) Comparison of range-of-motion and variability in upper body movements between transradial prosthesis users and able-bodied controls when executing goal-oriented tasks. J Neuroeng Rehabil. 11:132.
- Abstract:
- Current upper limb prostheses do not replace the active degrees-of-freedom distal to the elbow inherent to intact physiology. Limited evidence suggests that transradial prosthesis users demonstrate shoulder and trunk movements to compensate for these missing volitional degrees-of-freedom. The purpose of this study was to enhance understanding of the effects of prosthesis use on motor performance by comparing the movement quality of upper body kinematics between transradial prosthesis users and able-bodied controls when executing goal-oriented tasks that reflect activities of daily living.
- Keyword:
- Upper limbs, Transradial amputation, Kinematics, Trunk, Prosthesis
- Subject: MESH:
- Activities of Daily Living, Artificial Limbs, Biomechanical Phenomena, Movement--physiology, Range of Motion, Articular, Upper Extremity--physiology
- Creator:
- Major, Matthew Justin, Stine, Rebecca, Heckathorne, Craig W, Fatone, Stefania, Gard, Steven A
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2014
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Journal Article
- Title:
- Woman's Medical School at Northwestern University, 1870-1902 (3)
- Description:
- Third of a series of Galter Health Sciences Library posters featured as an adjunct to the U.S. National Library of Medicine's traveling exhibit, Changing the face of Medicine - Celebrating America's Women Physicians. [on display at Northwestern University, Feinberg School of Medicine, Lurie Medical Research Building, Chicago, IL from December 9, 2009-January 3, 2010]., The exhibit was organized by the National Library of Medicine and was sponsored by the Galter Health Sciences Library, the Institute for WomensHealth Research and the Northwestern Medical Women Faculty Organization. Sponsoring units presented posters during the exhibit demonstrating how women have changed the face of medicine at Northwestern. In addition, a panel of notable Northwestern women discussed their contributions to medicine and health care in the areasof research, education, and clinical care in Hughes Auditorium on December 7, 2009 at 3:00PM. The panel members were: Neena B. Schwartz, PhD, Teresa W. Woodruff, PhD, Erica Marsh, MD, MSCI, and Candace Tingen, BS, BA. A reception followed at 4:30PM.
- Original Bibliographic Citation:
- Sims, R. Woman's Medical School at Northwestern, 1870-1902 (3). Poster presented as adjunct to the NLM traveling exhibit, Changing the face of Medicine - Celebrating America's Women Physicians, December 2009-January 2010, Chicago, IL.
- Abstract:
- The traveling exhibit describes the remarkable progress women have made in professional training, achieving diversity and providing leadership in health care. Changing the Face of Medicine: Celebrating America’s Women Physicians begins with Elizabeth Blackwell, the first woman to earn an M.D. degree in America in 1849, and ends with women physicians today, who have achieved success in work once considered "unsuitable" for a woman.
- Keyword:
- Northwestern University Woman's Medical School
- Subject: MESH:
- Students, Medical--history, Schools, Medical, History of Medicine, Physicians, Women
- Subject: Geographic Name:
- Chicago (Ill.)
- Subject: Name:
- Northwestern University (Evanston, Ill.). Woman's Medical School
- Creator:
- Sims, Ronald H
- Contributor:
- Northwestern University (Evanston, Ill.). Women's Health Research Institute, Northwestern Medical Women Faculty Organization, Galter Health Sciences Library
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Page Number:
- 3
- Location:
- Chicago, Illinois, United States
- Language:
- English
- Date Created:
- 2009
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Exhibitions
- Title:
- Woman's Medical School at Northwestern University, 1870-1902 (2)
- Description:
- Second of a series of Galter Health Sciences Library posters featured as an adjunct to the U.S. National Library of Medicine's traveling exhibit, Changing the face of Medicine - Celebrating America's Women Physicians. [on display at Northwestern University, Feinberg School of Medicine, Lurie Medical Research Building, Chicago, IL from December 9, 2009-January 3, 2010]., The exhibit was organized by the National Library of Medicine and was sponsored by the Galter Health Sciences Library, the Institute for Womens Health Research and the Northwestern Medical Women Faculty Organization. Sponsoring units presented posters during the exhibit demonstrating how women have changed the face of medicine at Northwestern. In addition, a panel of notable Northwestern women discussed their contributions to medicine and health care in the areas of research, education, and clinical care in Hughes Auditorium on December 7, 2009 at 3:00PM. The panel members were: Neena B. Schwartz, PhD, Teresa W. Woodruff, PhD, Erica Marsh, MD, MSCI, and Candace Tingen, BS, BA. A reception followed at 4:30PM.
- Original Bibliographic Citation:
- Sims, R. Woman's Medical School at Northwestern, 1870-1902 (2). Poster presented as adjunct to the NLM traveling exhibit, Changing the face of Medicine - Celebrating America's Women Physicians, December 2009-January 2010, Chicago, IL.
- Abstract:
- The traveling exhibit describes the remarkable progress women have made in professional training, achieving diversity and providing leadership in health care. Changing the Face of Medicine: Celebrating America’s Women Physicians begins with Elizabeth Blackwell, the first woman to earn an M.D. degree in America in 1849, and ends with women physicians today, who have achieved success in work once considered "unsuitable" for a woman.
- Keyword:
- Northwestern University Women's Medical School
- Subject: MESH:
- Schools, Medical--history, Students, Medical, History of Medicine, Physicians, Women
- Subject: Geographic Name:
- Chicago (Ill.)
- Subject: Name:
- Northwestern University (Evanston, Ill.). Woman's Medical School
- Creator:
- Sims, Ronald H
- Contributor:
- Northwestern University (Evanston, Ill.). Women's Health Research Institute, Northwestern Medical Women Faculty Organization, Galter Health Sciences Library
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Page Number:
- 2
- Location:
- Chicago, Illinois, United States
- Language:
- English
- Date Created:
- 2009
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Exhibitions
- Title:
- Woman's Medical School at Northwestern University, 1870-1902 (1)
- Description:
- First of a series of Galter Health Sciences Library posters featured as an adjunct to the U.S. National Library of Medicine's traveling exhibit, Changing the face of Medicine - Celebrating America's Women Physicians. [on display at Northwestern University, Feinberg School of Medicine, Lurie Medical Research Building, Chicago, IL from December 9, 2009-January 3, 2010]. The exhibit was organized by the National Library of Medicine and was sponsored by the Galter Health Sciences Library, the Institute for Womens Health Research and the Northwestern Medical Women Faculty Organization. Sponsoring units presented posters during the exhibit demonstrating how women have changed the face of medicine at Northwestern. In addition, a panel of notable Northwestern women discussed their contributions to medicine and health care in the areas of research, education, and clinical care in Hughes Auditorium on December 7, 2009 at 3:00PM. The panel members were: Neena B. Schwartz, PhD, Teresa W. Woodruff, PhD, Erica Marsh, MD, MSCI, and Candace Tingen, BS, BA. A reception followed at 4:30PM.
- Original Bibliographic Citation:
- Sims, R. Woman's Medical School at Northwestern, 1870-1902 (1). Poster presented as adjunct to the NLM traveling exhibit, Changing the face of Medicine - Celebrating America's Women Physicians, December 2009-January 2010, Chicago, IL.
- Abstract:
- The traveling exhibit describes the remarkable progress women have made in professional training, achieving diversity and providing leadership in health care. Changing the Face of Medicine: Celebrating America’s Women Physicians begins with Elizabeth Blackwell, the first woman to earn an M.D. degree in America in 1849, and ends with women physicians today, who have achieved success in work once considered "unsuitable" for a woman.
- Keyword:
- Northwestern University Women's Medical School
- Subject: MESH:
- Schools, Medical--history, Students, Medical, History of Medicine, Physicians, Women
- Subject: Geographic Name:
- Chicago (Ill.)
- Subject: Name:
- Northwestern University (Evanston, Ill.). Woman's Medical School
- Creator:
- Sims, Ronald H
- Contributor:
- Northwestern University (Evanston, Ill.). Women's Health Research Institute, Northwestern Medical Women Faculty Organization, Galter Health Sciences Library
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Page Number:
- 1
- Location:
- Chicago, Illinois, United States
- Language:
- English
- Date Created:
- 2009
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Exhibitions
- Title:
- Ephus: multipurpose data acquisition software for neuroscience experiments
- Original Bibliographic Citation:
- Suter BA, O'Connor T, Iyer V, Petreanu LT, Hooks BM, Kiritani T, Svoboda K, Shepherd GM. (2010) Ephus: multipurpose data acquisition software for neuroscience experiments. Front Neural Circuits 4:100.
- Abstract:
- Physiological measurements in neuroscience experiments often involve complex stimulus paradigms and multiple data channels. Ephus (http://www.ephus.org) is an open-source software package designed for general-purpose data acquisition and instrument control. Ephus operates as a collection of modular programs, including an ephys program for standard whole-cell recording with single or multiple electrodes in typical electrophysiological experiments, and a mapper program for synaptic circuit mapping experiments involving laser scanning photostimulation based on glutamate uncaging or channelrhodopsin-2 excitation. Custom user functions allow user-extensibility at multiple levels, including on-line analysis and closed-loop experiments, where experimental parameters can be changed based on recently acquired data, such as during in vivo behavioral experiments. Ephus is compatible with a variety of data acquisition and imaging hardware. This paper describes the main features and modules of Ephus and their use in representative experimental applications.
- Keyword:
- Neuroscience, Neocortex, Software, Data
- Subject: MESH:
- Neurosciences--methods, Electrophysiology--instrumentation, Software, Data Collection, Information Storage and Retrieval
- Creator:
- Suter, Benjamin, Shepherd, Gordon M G, O'Connor, Timothy, Kiritani, Taro
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2010
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Journal Article
- Original Identifier:
- (PMID)21960959
- Title:
- Neurophotonics applications to motor cortex research: a review
- Original Bibliographic Citation:
- Suter BA, Yamawaki N, Borges K, Li X, Kiritani T, Hooks BM, Shepherd GM. (2014) Neurophotonics applications to motor cortex research: a review. Neurophotonics 1(1)
- Abstract:
- Neurophotonics methods offer powerful ways to access neuronal signals and circuits. We highlight recent advances and current themes in this area, emphasizing tools for mapping, monitoring, and manipulating excitatory projection neurons and their synaptic circuits in mouse motor cortex.
- Keyword:
- Neuroscience, Neocortex
- Subject: MESH:
- Optics and Photonics, Optogenetics, Motor Cortex, Pyramidal Cells, Mice, Neural Pathways
- Creator:
- Suter, Benjamin, Shepherd, Gordon M G, Yamawaki, Naoki, Borges, Katharine Ellen Munckton, Li, Xiaojian, Kiritani, Taro
- Publisher:
- SPIE, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2014
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Review
- Original Identifier:
- (PMID)25553337
- Title:
- Intrinsic Electrophysiology of Mouse Corticospinal Neurons: a Class-Specific Triad of Spike-Related Properties
- Original Bibliographic Citation:
- Suter, Benjamin A., Migliore, Michele, Shepherd, Gordon M G. (2013) Intrinsic Electrophysiology of Mouse Corticospinal Neurons: a Class-Specific Triad of Spike-Related Properties. Cereb Cortex. 23(8):1965-1977.
- Abstract:
- Corticospinal pyramidal neurons mediate diverse aspects of motor behavior. We measured spike-related electrophysiological properties of identified corticospinal neurons in primary motor cortex slices from young adult mice. Several consistent features were observed in the suprathreshold responses to current steps: 1) Corticospinal neurons fired relatively fast action potentials (APs; width at half-maximum 0.65 0.13 ms, mean standard deviation [SD]) compared with neighboring callosally projecting corticostriatal neurons. Corticospinal AP width was intermediate between 2 classes of inhibitory interneuron in layer 5B. Spike-to-spike variability in AP width and other spike waveform parameters was low, even during repetitive firing up to 20 Hz, that is, the relative narrowness of corticospinal APs was essentially frequency independent. 2) Frequency-current (f-I) relationships were nearly linear. 3) Trains of APs displayed regular firing, with rates typically staying constant or accelerating over time. Corticospinal neurons recorded from older mice (up to 4 months) or from a separate lateral cortical area (Region B; corresponding to secondary somatosensory cortex) showed generally similar intrinsic properties. Our findings have implications for interpreting spike waveforms of in vivo recorded neurons in the motor cortex. This analysis provides a framework for further biophysical and computational investigations of corticospinal neurons and their roles in motor cortical function.
- Keyword:
- Neuroscience, Neocortex
- Subject: MESH:
- Action Potentials, Interneurons, Mice, Inbred C57BL, Motor Cortex, Pyramidal Tracts, Pyramidal Cells
- Creator:
- Suter, Benjamin, Shepherd, Gordon M G, Migliore, Michele
- Publisher:
- Oxford University Press, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2012
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Journal Article
- Original Identifier:
- (PMID)22761308
6418. Toward an integrated approach to perception and action: conference report and future directions
- Title:
- Toward an integrated approach to perception and action: conference report and future directions
- Original Bibliographic Citation:
- Gordon G, Kaplan DM, Lankow B, Little DY, Sherwin J, Suter BA, Thaler L. (2011) Toward an integrated approach to perception and action: conference report and future directions. Front Syst Neurosci. 5:20.
- Abstract:
- This article was motivated by the conference entitled "Perception & Action - An Interdisciplinary Approach to Cognitive Systems Theory," which took place September 14-16, 2010 at the Santa Fe Institute, NM, USA. The goal of the conference was to bring together an interdisciplinary group of neuroscientists, roboticists, and theorists to discuss the extent and implications of action-perception integration in the brain. The motivation for the conference was the realization that it is a widespread approach in biological, theoretical, and computational neuroscience to investigate sensory and motor function of the brain in isolation from one another, while at the same time, it is generally appreciated that sensory and motor processing cannot be fully separated. Our article summarizes the key findings of the conference, provides a hypothetical model that integrates the major themes and concepts presented at the conference, and concludes with a perspective on future challenges in the field.
- Keyword:
- Neuroscience, Neocortex
- Subject: MESH:
- Perception--physiology, Sensorimotor Cortex--physiology, Sensation--physiology, Models, Neurological, Movement--physiology, Robotics, Brain--physiology
- Creator:
- Suter, Benjamin
- Publisher:
- Frontiers Media, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2011
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Journal Article
- Original Identifier:
- (PMID)21541257
- Title:
- Reciprocal Interareal Connections to Corticospinal Neurons in Mouse M1 and S2
- Original Bibliographic Citation:
- Suter, Benjamin A., Shepherd, Gordon M.G. (2015) Reciprocal Interareal Connections to Corticospinal Neurons in Mouse M1 and S2. J Neurosci 35:2959-2974.
- Abstract:
- Primary motor (M1) and secondary somatosensory (S2) cortices, although anatomically and functionally distinct, share an intriguing cellular component: corticospinal neurons (CSP) in layer 5B. Here, we investigated the long-range circuits of CSPs in mouse forelimb-M1 and S2. We found that interareal projections (S2 M1 and M1 S2) monosynaptically excited pyramidal neurons across multiple layers, including CSPs. Area-specific differences were observed in the relative strengths of inputs to subsets of CSPs and other cell types, but the general patterns were similar. Furthermore, subcellular mapping of the dendritic distributions of these corticocortical excitatory synapses onto CSPs in both areas also showed similar patterns. Because layer 5B is particularly thick in M1, but not S2, we studied M1-CSPs at different cortical depths, quantifying their dendritic morphology and mapping inputs from additional cortical (M2, contralateral M1, and local layer 2/3) and thalamic (VL nucleus) sources. These results indicated that CSPs exhibit area-specific modifications on an otherwise conserved synaptic organization, and that different afferents innervate M1-CSP dendritic domains in a source-specific manner. In the cervical spinal cord, CSP axons from S2 and M1 partly converged on middle layers, but S2-CSP axons extended further dorsally, and M1-CSP axons ventrally. Thus, our findings identify many shared features in the circuits of M1 and S2 and show that these areas communicate via mutual projections that give each area monosynaptic access to the other area's CSPs. These interareally yoked CSP circuits may enable M1 and S2 to operate in a coordinated yet differentiated manner in the service of sensorimotor integration.
- Keyword:
- Neuroscience, Neocortex
- Subject: MESH:
- Brain Mapping, Luminescent Proteins, Mice, Inbred C57BL, Mice, Transgenic, Motor Cortex, Neural Pathways, Pyramidal Tracts, Somatosensory Cortex, Synapses, Thalamus
- Creator:
- Suter, Benjamin, Shepherd, Gordon M. G.
- Publisher:
- The Journal of Neuroscience, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Journal Article
- Original Identifier:
- (PMID)25698734
- Title:
- A genuine layer 4 in motor cortex with prototypical synaptic circuit connectivity
- Original Bibliographic Citation:
- Chadderdon GL, Mohan A, Suter BA, Neymotin SA, Kerr CC, Francis JT, Shepherd GM, Lytton WW. (2014) Neural Comput. 26(7):1239-1262.
- Abstract:
- The motor cortex (M1) is classically considered an agranular area, lacking a distinct layer 4 (L4). Here, we tested the idea that M1, despite lacking a cytoarchitecturally visible L4, nevertheless possesses its equivalent in the form of excitatory neurons with inputoutput circuits like those of the L4 neurons in sensory areas. Consistent with this idea, we found that neurons located in a thin laminar zone at the L3/5A border in the forelimb area of mouse M1 have multiple L4-like synaptic connections: excitatory input from thalamus, largely unidirectional excitatory outputs to L2/3 pyramidal neurons, and relatively weak long-range corticocortical inputs and outputs. M1-L4 neurons were electrophysiologically diverse but morphologically uniform, with pyramidal-type dendritic arbors and locally ramifying axons, including branches extending into L2/3. Our findings therefore identify pyramidal neurons in M1 with the expected prototypical circuit properties of excitatory L4 neurons, and question the traditional assumption that motor cortex lacks this layer.
- Keyword:
- Neuroscience, Neocortex
- Subject: MESH:
- Action Potentials, Adenoviridae--genetics, Axons, Dendrites, Genetic Vectors, Mice, Motor Cortex, Pyramidal Cells, Synapses, Synaptic Potentials, Synaptic Transmission, Thalamus--physiology
- Creator:
- Suter, Benjamin, Shepherd, Gordon M G, Yamawaki, Naoki, Borges, Katharine Ellen Munckton
- Publisher:
- eLife, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2014
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Journal Article
- Original Identifier:
- (PMID)25525751