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- Title:
- Vaccinations and Dravet Syndrome
- Abstract:
- Investigators from various university hospitals, reference medical institutions and epilepsy centers, and the national institute for public health and environment in the Netherlands, studied the effect of vaccinations on seizure risk and disease course in patients with Dravet syndrome (DS).
- Keyword:
- Development, Seizure Risk, Prognosis, Dravet Syndrome, Vaccinations
- Subject:
- Seizure Disorders
- Subject: MESH:
- Neurosurgery, Child Development, Child, Pediatrics, Brain Diseases, Neurology, Nervous System Diseases, Infant
- Creator:
- Korff, Christian M.
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- PNB-29-85
- Title:
- Histopathology of Polymicrogyria
- Abstract:
- Investigators from Sainte Justine Hospital (Montreal), Montreal Neurological Hospital and Institute, King's College Hospital (London), and John Radcliffe Hospital (Oxford) retrospectively reviewed medical records, autopsy reports, and genetic studies containing Polymicrogyria.
- Keyword:
- Cortical Malformation, Polymicrogyria, Histopathology
- Subject:
- CNS Malformations
- Subject: MESH:
- Neurology, Nervous System Diseases, Child Development, Pediatrics, Brain Diseases, Neurosurgery, Infant, Child
- Creator:
- Fudyma, Iga, Wadhwani, Nitin R.
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- PNB-29-86
- Title:
- Language Impairment in Adolescents with Sydenham Chorea
- Abstract:
- Investigators from hospitals in Brazil tested verbal fluency in 20 adolescent patients, ages ranged from 11 to 16 years (mean 13.8 years), with Sydenham chorea compared with 20 patients with rheumatic fever without chorea and 20 healthy controls, matched for age and gender.
- Keyword:
- Rheumatic Fever, Verbal Fluency, Comprehension, Sydenham Chorea
- Subject: MESH:
- Infant, Neurosurgery, Child, Pediatrics, Child Development, Neurology, Nervous System Diseases, Movement Disorders, Brain Diseases
- Creator:
- Millichap, J. Gordon
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- PNB-29-87
- Title:
- Epstein-Barr Virus Neurologic Complications
- Abstract:
- Investigators at the Karol Marcinkowski University of Medical Sciences, Poznan, Poland, analyzed the records of 194 children diagnosed with Epstein-Barr virus infection and having the viral capsid antigen IgM antibody.
- Keyword:
- Cerebellitis, Encephalitis, Myeloradiculitis, Infectious Mononucleosis, Children, Epstein-Barr Virus
- Subject:
- Infectious/Autoimmune Disorders
- Subject: MESH:
- Infant, Child Development, Neurology, Nervous System Diseases, Brain Diseases, Pediatrics, Neurosurgery, Child
- Creator:
- Millichap, J. Gordon
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- PNB-29-88
- Title:
- The Genetics of Febrile Seizures
- Abstract:
- Investigators from Virginia Commonwealth University, Norwegian Center for Epilepsy and University of Southern Denmark carried out twin studies to analyse the genetic influence of developing epilepsy after febrile seizures.
- Keyword:
- Twin studies, Febrile seizures, Epilepsy
- Subject:
- Genetic Disorders
- Subject: MESH:
- Neurosurgery, Child Development, Infant, Nervous System Diseases, Pediatrics, Child, Neurology, Brain Diseases
- Creator:
- Ram, Dipak, Newton, Richard
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- PNB-29-90
- Title:
- Incidental Findings: The Importance of Pretest Counseling
- Abstract:
- Researchers at the University of Bourgogne in Dijon, France surveyed French geneticists who were members of the Association Franais des Gnticiens on incidental findings (IF) found on array-based comparative genomic hybridization (aCGH) technology retrospectively over a seven-year period.
- Keyword:
- incidental findings, aCGH, ethical issues, pre-test information
- Subject:
- Genetic Disorders
- Subject: MESH:
- Infant, Child, Brain Diseases, Neurology, Pediatrics, Child Development, Neurosurgery, Nervous System Diseases
- Creator:
- Buchtel, Kathryn M., Leeth, Elizabeth A.
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- PNB-29-91
- Title:
- Incidence of Dravet Syndrome in a US Population
- Abstract:
- Investigators from the University of California, San Francisco and Kaiser Permanente report the incidence of Dravet Syndrome in a population based cohort.
- Keyword:
- Epilepsy, Pediatrics, Genetics
- Subject:
- Seizure Disorders
- Subject: MESH:
- Infant, Child Development, Neurosurgery, Nervous System Diseases, Pediatrics, Child, Brain Diseases, Neurology
- Creator:
- Krueger, Jena, Berg, Anne T.
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- PNB-29-92
- Title:
- Prediction of Infantile Spasms Recurrence after ACTH Therapy
- Abstract:
- Investigators from Okayama University Hospital, Japan, studied the predictive value of serial EEG findings (every 2 to 4 weeks) in relapse of epileptic spasms after synthetic ACTH therapy in patients with West syndrome (WS).
- Keyword:
- West syndrome, Infantile Spasms, ACTH, EEG
- Subject:
- Seizure Disorders
- Subject: MESH:
- Neurosurgery, Nervous System Diseases, Infant, Child Development, Child, Neurology, Pediatrics, Brain Diseases
- Creator:
- Millichap, John J., Millichap, J. Gordon
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- PNB-29-93
- Title:
- Complementary/Alternative versus Prescription Medications
- Abstract:
- Investigators from the Mayo Clinic, Rochester MN, determined the use of complementary and alternative medicine (CAM) in an outpatient pediatric neurology clinic, and assessed family attitudes toward the efficacy of CAM versus prescription medications.
- Keyword:
- Complementary and Alternative Medicine, Headache, Epilepsy, Chronic Fatigue
- Subject:
- Complementary/Integrative Therapies
- Subject: MESH:
- Infant, Child Development, Neurosurgery, Nervous System Diseases, Pediatrics, Child, Brain Diseases, Neurology
- Creator:
- Millichap, J. Gordon
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- PNB-29-94
- Title:
- Risk of Tics with Psychostimulants for ADHD
- Abstract:
- Investigators at Yale University, New Haven, CT, conducted a meta-analysis to examine the risk of new onset or worsening of tics caused by psychostimulants used in the treatment of children with ADHD.
- Keyword:
- Tics, Amphetamine, ADHD, Meta-Analysis, Psychostimulant Medications, Methylphenidate
- Subject: MESH:
- Movement Disorders, Nervous System Diseases, Brain Diseases, Neurosurgery, Child, Infant, Child Development, Neurology, Pediatrics
- Creator:
- Millichap, J. Gordon
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- PNB-29-95
- Title:
- Acute Flaccid Myelitis Outbreak
- Abstract:
- Investigators from the University School of Medicine, Salt Lake City, Utah, report an outbreak of acute flaccid myelitis (AFM) occurring in 2014-2015 in several States and reported to the CDC.
- Keyword:
- Enteroviruses, Motor Cranial Neuropathy, Flaccid Myelitis, Spinal Gray Matter
- Subject:
- Infectious/Autoimmune Disorders
- Subject: MESH:
- Child Development, Neurology, Nervous System Diseases, Infant, Brain Diseases, Neurosurgery, Pediatrics, Child
- Creator:
- Millichap, J. Gordon
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- PNB-29-96
- Title:
- A graph data model facilitates analysis of collaboration in an emergency department
- Description:
- Poster presented at the American Medical Informatics Association (AMIA) 2015 Annual Symposium, Nov. 14-18, San Francisco, CA.
- Keyword:
- collaboration, ed department, workflow, graph database, networks
- Subject: MESH:
- Workflow, Emergency Service, Hospital, Cooperative Behavior
- Subject: LCSH:
- Graph theory
- Subject: Name:
- Northwestern Memorial Hospital
- Creator:
- Carson, Matthew Brandon, Gravenor, Stephanie Jasmine, Lee, Young Ji, Scholtens, Denise M, Frailey, Conor N., Soulakis, Nicholas Dean
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2015-10-09
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Poster
- Title:
- Expression of receptors for plasminogen activators on endothelial cell surface depends on their origin
- Keyword:
- plasminogen plasmin system
- Creator:
- Kwaan, Hau C
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Date Created:
- 2004
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Title:
- Biologic role of the plasminogen-plasmin system: thrombolysis, bleeding and beyond
- Original Bibliographic Citation:
- Kwaan, H. C., & Mazar, A. P. (2013). Biologic Role of the PlasminogenPlasmin System: Thrombolysis, Bleeding, and Beyond. Semin Thromb Hemost, 39(04), 327-328. doi:10.1055/s-0033-1343616
- Keyword:
- plasminogen-plasmin system
- Subject: MESH:
- Fibrinolysis, Plasminogen Activators, Plasminogen Inactivators, Blood Coagulation
- Creator:
- Kwaan, Hau C, Mazar, Andrew P
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2013
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Title:
- Early death in patients with acute promyelocytic leukemia : proceedings from a live roundtable at the 2010 American Society of Hematology Annual Meeting, December 4-7, 2010, Orlando, Florida, The pathophysiology of coagulopathy in APL
- Original Bibliographic Citation:
- Kwaan, H. C. (2011). The Pathophysiology of Coagulopathy in APL. Clinical advances in hematology & oncology : H&O, 9(2), 7-9.
- Keyword:
- Acute Promyelocytic Leukemia
- Subject: MESH:
- Leukemia, Promyelocytic, Acute, Blood Coagulation, Hemorrhage
- Creator:
- Kwaan, Hau C
- Publisher:
- Millennium Medical Publishing, DigitalHub. Galter Health Sciences Library
- Location:
- Orlando, Florida, United States
- Language:
- English
- Date Created:
- 2011-02
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Conference Proceeding
- Title:
- Role of microparticles in the hemostatic dysfunction in acute promyelocytic leukemia
- Original Bibliographic Citation:
- Kwaan, H. C., & Rego, E. M. (2010). Role of microparticles in the hemostatic dysfunction in acute promyelocytic leukemia. Semin Thromb Hemost, 36(8), 917-924. doi:10.1055/s-0030-1267045
- Abstract:
- Serious bleeding and thrombotic complications are frequent in acute promyelocytic leukemia (APL) and are major causes of morbidity and mortality. Microparticles (MP) have been used to study the risk and pathogenesis of thrombosis in many malignant disorders. To date, from published articles, this approach had not been applied to APL. In this article, the hemostatic dysfunction in this disorder is briefly reviewed. A study design to address this problem using MP is described. MP bearing tissue factor, profibrinolytic factors (tissue plasminogen activator and annexin A2), and the antifi-brinolytic factor plasminogen activator inhibitor type 1 were measured using flow cytometry. The cellular origin of the MP was identified by specific cell surface markers. Comparison of the various populations of MP was made between samples collected at the time of diagnosis with those collected at molecular remission. Preliminary data suggest that this approach is feasible.
- Keyword:
- Acute Promyelocytic Leukemia
- Subject: MESH:
- Leukemia, Promyelocytic, Acute, Hemorrhage, Thromboplastin, Annexin A2, Blood Coagulation
- Creator:
- Kwaan, Hau C, Rego, Eduardo Magalhaes
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2010
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Title:
- The unique hemostatic dysfunction in acute promyelocytic leukemia
- Original Bibliographic Citation:
- Kwaan, H. C. (2014). The unique hemostatic dysfunction in acute promyelocytic leukemia. Semin Thromb Hemost, 40(3), 332-336. doi:10.1055/s-0034-1370792
- Abstract:
- The hemostatic abnormalities seen in acute promyelocytic leukemia (APL) are unique and account for much of the morbidity and mortality of this disorder. Almost all patients present at diagnosis with laboratory findings of intravascular coagulation along with increased fibrinolysis. This unusual combination is correlated to the clinical manifestations with high risk of both bleeding and thrombosis. Recent studies have revealed that the leukemic promyelocytes in APL express increased amounts of tissue factor as well as elements of the fibrinolytic system, including tissue plasminogen activator, annexin A2, and plasminogen activator inhibitor type 1. These changes are responsive to differentiation therapy with all-trans-retinoic acid (ATRA) or with arsenic trioxide (ATO). Despite a dramatic reduction in mortality seen since the introduction of differentiation therapy with ATRA or with ATO, a large number of deaths still occur before complete remission is achieved. The early deaths are mostly attributable to the presenting coagulopathy. The prevention and management of this hemostatic abnormality have thus far been unsuccessful and remain a challenge to bring about a higher cure rate for this disease.
- Keyword:
- Acute Promyelocytic Leukemia
- Subject: MESH:
- Leukemia, Promyelocytic, Acute, Blood Coagulation, Hemorrhage
- Creator:
- Kwaan, Hau C
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2014-03-03
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Title:
- Adverse effects of drugs on hemostasis and thrombosis
- Description:
- Preface to: Seminars in thrombosis and hemostasis, Vol. 38, No. 8, 2012.
- Original Bibliographic Citation:
- Kwaan, H. C., & Bennett, C. L. (2012). Adverse Effects of Drugs on Hemostasis and Thrombosis. Semin Thromb Hemost, 38(08), 755-758. doi:10.1055/s-0032-1329596
- Keyword:
- hemostasis, thrombosis
- Subject: MESH:
- Drug-Related Side Effects and Adverse Reactions, Hemostasis, Thrombosis
- Creator:
- Kwaan, Hau C, Bennett, Charles
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2012
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Title:
- Adverse effects on hemostatic function of drugs used in hematological malignancies
- Original Bibliographic Citation:
- Zakarija, A., & Kwaan, H. C. (2007). Adverse effects on hemostatic function of drugs used in hematologic malignancies. Semin Thromb Hemost, 33(4), 355-364. doi:10.1055/s-2007-976171
- Abstract:
- The adverse effects of drugs used in the treatment of hematologic malignancies are among the many factors contributing to the increased risk of both thrombosis and bleeding. These effects most often occur when combination of drugs are given. Some, such as L-asparaginase, result in both bleeding and thrombosis. Consideration must be given also to the bleeding or prothrombotic risk of the underlying hematologic disorder. The commonly used drugs with adverse effects on hemostasis include L-asparaginase, corticosteroids, inhibitors of vascular endothelial growth factor, gemtuzumab ozogamicin, thalidomide, and immunomodulatory derivatives of Thalidomide, and the hematopoietic growth factors. In addition, the syndrome of thrombotic microangiopathy may be brought on by several other drugs. Thus, a full understanding of these adverse effects is necessary in treating these disorders.
- Keyword:
- microparticles and pregnancy
- Subject: MESH:
- Thrombosis, Drug-Related Side Effects and Adverse Reactions, Hemostasis, Hematologic Neoplasms
- Creator:
- Zakarija, Anaadriana, Kwaan, Hau C
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2007
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Title:
- Thrombotic and bleeding complications associated with chemotherapy
- Original Bibliographic Citation:
- McMahon, B. J., & Kwaan, H. C. (2012). Thrombotic and bleeding complications associated with chemotherapy. Semin Thromb Hemost, 38(8), 808-817. doi:10.1055/s-0032-1328885
- Abstract:
- It is well recognized that cancer patients have an increased risk of thrombosis and bleeding. Contributory factors to thrombotic complications include prothrombotic risks carried by many chemotherapeutic agents, type of cancer, stage of cancer, age, and comorbidities. Surgical procedures and the presence of an indwelling vascular device, often used as a mode of delivery for chemotherapy, further increase the risk. Correlative studies have demonstrated upregulation of coagulation in response to chemotherapeutics, and clinical studies have shown that various cancer treatments are independent risk factors for thrombotic complications. It has also been shown that patients who develop thrombosis during treatment have a worse overall prognosis. Mechanisms for chemotherapy and cancer-associated thrombosis are not well understood. Better insight into the mechanism for thrombosis may help better identify those cancer patients at highest risk, who may then benefit from up-front anticoagulant prophylaxis.
- Keyword:
- chemotherapy, thrombosis
- Subject: MESH:
- Thrombosis, Neoplasms
- Subject: LCSH:
- Chemotherapy--Complications
- Creator:
- McMahon, Brandon J, Kwaan, Hau C
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2012
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 23055392
- Title:
- Correction of hyperviscosity by apheresis
- Original Bibliographic Citation:
- Zarkovic, M., & Kwaan, H. C. (2003). Correction of hyperviscosity by apheresis. Semin Thromb Hemost, 29(5), 535-542. doi:10.1055/s-2003-44560
- Abstract:
- Therapeutic apheresis is an extracorporeal blood purification technique designed for the removal of either plasma (plasmapheresis) or cellular blood components (cytapheresis). One of the main indications for the use of apheresis is in the treatment of the hyperviscosity syndromes that can result from either the presence of abnormal plasma components, such as antibodies, immune complexes, paraproteins, and cryoglobulins, or the excessive increase in blood cells as seen in polycythemia, leukemias, and myeloproliferative diseases. Apheresis involves withdrawal of anticoagulated blood via a vascular catheter, separation of different blood components by either centrifugation or membrane filtration, removal of the undesired component, and reinfusion of the remaining components with replacement fluid into the patient. The centrifugal method can be intermittent or continuous, the latter being faster and fully automated, and is principally used in North America. The membrane filtration technique, mainly used in Europe and Japan, involves the filtration of blood by filters of different pore sizes. These are used sequentially in a process called double or cascade filtration, enabling removal of specific plasma pathogens without need for replacement fluids. In paraproteinemias, hyperviscosity syndrome is most commonly seen with Waldenstrm's macroglobulinemia, followed by immunoglobulin (Ig) A and IgG (3) multiple myeloma. Single plasmapheresis with one plasma volume replacement (about 3 L) usually results in a dramatic improvement in patients with macrogobulinemia because of its predominant intravascular distribution, whereas repeated plasmapheresis is necessary with other types of paraproteins. Cryofiltration apheresis using a high-capacity cryofilter is specific for the removal of cryoglobulins. In leukemias with hyperleukocytosis, there are no evidence-based guidelines for use of leukapheresis, but it is commonly initiated when white blood cells (WBC) are > 100,000/microL or even with lower counts if leukostasis symptoms are present, especially in acute myeloid leukemia. Erythrocytapheresis and plateletpheresis are mostly used in the acute management of symptomatic patients with polycythemia vera (PV), essential thrombocytosis, and sickle cell disease.
- Keyword:
- apheresis, hyperviscosity
- Subject: MESH:
- Blood Component Removal, Blood Viscosity
- Creator:
- Zarkovic, Mirjana, Kwaan, Hau C
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2003
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Title:
- Thrombotic microangiopathy in the cancer patient
- Original Bibliographic Citation:
- Kwaan, H. C., & Gordon, L. I. (2001). Thrombotic microangiopathy in the cancer patient. Acta Haematol, 106(1-2), 52-56. https://doi.org/10.1159/000046589
- Abstract:
- Thrombotic microangiopathy, manifesting as thrombotic thrombocytopenic purpura (TTP) or hemolytic uremic syndrome, is a common complication in cancer patients. It shares the pathogenic microvascular occlusive lesion and many clinical manifestations as the classical TTP, but the spectrum of complications varies widely. Several subsets are seen, including a microangiopathic hemolyticanemia in advanced cancer, chemotherapeutic drug-associated microangiopathy and those with the transplant setting. The prognosis is not as favorable as in classical TTP. Anecdotal reports indicate that responses are seen with plasma exchange and with immunoadsorption.
- Keyword:
- hematology
- Subject: MESH:
- Thrombotic Microangiopathies, Purpura, Thrombotic Thrombocytopenic, Neoplasms, Hemolytic-Uremic Syndrome
- Creator:
- Kwaan, Hau C, Gordon, Leo I
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2001
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 11549777
- Title:
- Pathogenesis of increased risk of thrombosis in cancer
- Original Bibliographic Citation:
- Kwaan, H. C., Parmar, S., & Wang, J. (2003). Pathogenesis of increased risk of thrombosis in cancer. Semin Thromb Hemost, 29(3), 283-290. doi:10.1055/s-2003-40966
- Abstract:
- Since the observations of Trousseau, not only has the association of cancer and thrombosis been widely recognized but its pathogenesis is now better understood. Attention to the tumor cell as an important source of procoagulants has also contributed to our knowledge of this problem. Tumor cells express tissue factor (TF) and a cancer procoagulant (CP). TF is dormant in the living cell. However, it is activated during apoptosis of the cell, initiating the coagulation cascade and leading to thrombin generation. Because increased apoptosis occurs during treatment with chemotherapeutic agents, hormones, radiation, and hematopoietic growth factors, as well as when there is rapid tumor proliferation, the thrombosis risk is heightened accordingly. These developments have obvious basic and clinical implications.
- Keyword:
- hematology
- Subject: MESH:
- Neoplasms, Thrombosis, Apoptosis, Fibrinolysis, Thromboplastin
- Creator:
- Kwaan, Hau C, Parmar, Simrit, Wang, Jun
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2003
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 12888932
- Title:
- Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports
- Original Bibliographic Citation:
- Swisher, K. K., Doan, J. T., Vesely, S. K., Kwaan, H. C., Kim, B., Lammle, B., . . . George, J. N. (2007). Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports. Haematologica, 92(7), 936-943.
- Abstract:
- BACKGROUND AND OBJECTIVES: The thrombotic thrombocytopenic purpura-hemolytic uremic syndromes (TTP-HUS) have diverse etiologies, clinical manifestations, and risk factors, but the events that may trigger acute episodes are often unclear. We describe the occurrence of TTP-HUS following pancreatitis and consider whether pancreatitis may be a triggering event for acute episodes of TTP-HUS. DESIGN AND METHODS: We report on three patients from the Oklahoma Registry and two patients from Northwestern University who had an acute episode of TTP-HUS following pancreatitis. A systematic review of published case reports was performed to identify additional patients who had TTP-HUS following pancreatitis. RESULTS: In each of our five patients there was an apparent etiology of alcoholism or common bile duct obstruction for the pancreatitis and no evidence of TTP-HUS when the pancreatitis was diagnosed. Two patients had severe ADAMTS13 deficiency with an inhibitor; in one of these patients TTP-HUS recurred following a subsequent recurrent episode of pancreatitis. The systematic review identified 16 additional patients who had TTP-HUS following pancreatitis; recurrent TTP-HUS occurred in three of these patients following a subsequent episode of recurrent pancreatitis. In all 21 patients, the interval between the diagnosis of pancreatitis and TTP-HUS was short (1-13 days; median, 3 days). The three Oklahoma patients represent approximately 1% of the 356 patients in the Registry. INTERPRETATION AND CONCLUSIONS: These observations suggest that in some patients pancreatitis, a disorder that results in an intense systemic inflammatory response, may be a triggering event for acute episodes of TTP-HUS.
- Keyword:
- TTP, HUS
- Subject: MESH:
- Purpura, Thrombotic Thrombocytopenic, Hemolytic-Uremic Syndrome, Pancreatitis
- Creator:
- Swisher, Karen K., Doan, John T., Vesely, Sara K., Kwaan, Hau C, Kim, Benjamin, Lmmle, Bernhard, Hovinga, Johanna A. Kremer, George, James N.
- Publisher:
- Ferrata Storti Foundation, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2007
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID)17606444
- Title:
- Role of plasma proteins in whole blood viscosity : a brief clinical review
- Original Bibliographic Citation:
- Kwaan, H. C. (2010). Role of plasma proteins in whole blood viscosity: a brief clinical review. Clin Hemorheol Microcirc, 44(3), 167-176. doi:10.3233/ch-2010-1271
- Abstract:
- Whole blood viscosity is affected by a number of factors, among which plasma proteins are a major component. They exert their effects either directly or through their influence on red cell aggregation. Changes in fibrinogen and in immunoglobulins, under both physiologic and pathologic conditions can increase whole blood viscosity. Blood flow through the microvasculature is impaired when viscosity increases, leading to tissue ischemia and a syndrome complex usually referred to as the hyperviscosity syndrome. Abnormalities of fibrinogen greatly increase its ability to cause red cell aggregation, and is a contributory pathogenic factor in ischemic heart disease and stroke. Immunoglobulins may affect blood viscosity directly, or by increasing the red cell aggregation. Changes are seen in many clinical disorders, ranging from inflammatory diseases to plasma cell dyscrasias. The clinical manifestations may be mild and often unnoticed, or they may be life threatening requiring emergency plasmapheresis. Proper management requires a clear understanding of the underlying pathology. When the symptom complex indicates a high probability of the hyperviscosity syndrome, it should lead to early diagnosis and treatment. Therapeutic approaches should include both removing the abnormal plasma protein and treating the primary cause.
- Keyword:
- blood viscosity
- Subject: MESH:
- Fibrinogen, Blood Viscosity, Blood Proteins, Immunoglobulins
- Creator:
- Kwaan, Hau C
- Publisher:
- IOS Press, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2010
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 20364062
- Title:
- Microvascular thrombosis : a serious and deadly pathologic process in multiple diseases
- Original Bibliographic Citation:
- Kwaan, H. C. (2011). Microvascular thrombosis: a serious and deadly pathologic process in multiple diseases. Semin Thromb Hemost, 37(8), 961-978. doi:10.1055/s-0031-1297375
- Abstract:
- Much of our understanding of the pathogenesis of thrombosis has long been based on observations made on large blood vessels. Nevertheless, there has been a recent shift in our attention to the microvasculature and to how microcirculatory occlusion affects function of various organs in diseases. This article provides an overview of microthrombosis in small blood vessels, with discussion of the progressive stages of its development. The initial event is triggered by a variety of diseases, followed by a second phase when multiple contributory factors amplify the process with the final phase of microvascular occlusion and microvascular thrombosis. The outcome is either recovery or injury to the affected organ. If the process is generalized, it is often associated with catastrophic or fatal outcomes. Our current knowledge of the major role of contributory factors leads to a new paradigm. A therapeutic approach limited to a single target of the underlying pathogenic factor, such as the use of anticoagulants, is insufficient and too often unsuccessful. Simultaneous management of all the contributory factors should therefore be considered.
- Keyword:
- leukemia
- Subject: MESH:
- Thrombosis, Disseminated Intravascular Coagulation, Microvessels
- Creator:
- Kwaan, Hau C
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2011
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 22198861
- Title:
- Thromboembolic and bleeding complications in acute leukemia
- Original Bibliographic Citation:
- Kwaan, H. C., & Huyck, T. (2010). Thromboembolic and bleeding complications in acute leukemia. Expert Rev Hematol, 3(6), 719-730. doi:10.1586/ehm.10.71
- Abstract:
- The risk of both thromboembolic and bleeding complications is high in acute leukemia. This double hazard has a significant negative impact on the morbidity and mortality of patients with this disease. The clinical manifestations of both complications show special features specific to the form of acute leukemia. Recognition of these characteristics is important in the diagnosis and management of acute leukemia. In this article, several additional issues are addressed, including the features of bleeding and thrombosis in acute promyelocytic leukemia, the current understanding of the leukostasis syndrome and the iatrogenic complications including catheter-associated thrombosis, and the adverse effects of therapeutic agents used in acute leukemia. As regards the bleeding complications, thrombocytopenia is a major cause. Corrective measures, including recent guidelines on platelet transfusions, are provided.
- Keyword:
- leukemia
- Subject: MESH:
- Thrombosis, Leukemia, Promyelocytic, Acute, Fibrinolysis, Hemorrhage, Platelet Transfusion, Leukostasis
- Creator:
- Kwaan, Hau C, Huyck, Timothy
- Publisher:
- Taylor & Francis, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2010
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Review
- Original Identifier:
- (PMID) 21091148
- Title:
- Hyperviscosity in polycythemia vera and other red cell abnormalities
- Original Bibliographic Citation:
- Kwaan, H. C., & Wang, J. (2003). Hyperviscosity in polycythemia vera and other red cell abnormalities. Semin Thromb Hemost, 29(5), 451-458. doi:10.1055/s-2003-44552
- Abstract:
- Thrombosis is a major cause of mortality and morbidity in polycythemia vera (PV). The wide range of thrombotic events reflects the complex picture in PV. There are multiple factors involved in thrombogenesis in this disease, including increased hematocrit, thrombocytosis, impaired fibrinolytic activity, platelet activation, leukocyte activation, endothelial damage, interactions between platelets and endothelium, various modalities of therapy, and increased in whole-blood viscosity. Among them, the increase in blood viscosity, and hence the impairment of blood flow, is the major factor. In this article, the role of hyperviscosity in PV is reviewed. A high hematocrit occurs under PV and many other conditions with abnormal red blood cell aggregation. The impaired capillary blood flow results in neurological manifestations and increased bleeding risk in PV. Thrombotic complications can also occur in both arteries and veins and manifest as stroke, myocardialinfarction, deep vein thrombosis, or pulmonary embolism. The hemodynamic principle is aptly applied in the management of PV. The most important objective is the reduction of the patient's hematocrit.
- Keyword:
- hemologic abnormalities
- Subject: MESH:
- Polycythemia Vera, Blood Viscosity, Erythrocytes, Abnormal
- Creator:
- Kwaan, Hau C, Wang, Jun
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2003
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 14631544
- Title:
- Rheologic abnormalities and thromboembolic complications in heart disease : spontaneous echo contrast and red cell aggregation
- Original Bibliographic Citation:
- Kwaan, H. C., Sakurai, S., & Wang, J. (2003). Rheological abnormalities and thromboembolic complications in heart disease: spontaneous echo contrast and red cell aggregation. Semin Thromb Hemost, 29(5), 529-534. doi:10.1055/s-2003-44559
- Abstract:
- The role of abnormal rheological changes in the pathogenesis of thromboembolism has received much attention in recent years, especially in the field of cardiology. Such changes are sometimes seen in an echocardiogram as a smokelike haze known as spontaneous echo contrast (SEC). The presence and severity of SEC correlate with dilated cardiac chambers and the incidence of thromboembolic complications. It is caused by increased red cell aggregation and increased fibrinogen levels, both of which are known risk factors for thrombosis. Although not used clinically, measurements of red cell aggregation can be made in research settings. This can provide findings that give insight into factors causing increased red cell aggregation. A small series of patients with angina pectoris was studied with the Myrenne aggregometer for red cell aggregation. The results, which show correlation between the plasma fibrinogen and triglyceride levels, are presented. As yet, there are only a few therapeutic guidelines for the correction of abnormally high fibrinogen levels in patients at risk.
- Keyword:
- hemologic abnormalities
- Subject: MESH:
- Echocardiography, Angina Pectoris, Fibrinogen, Thromboembolism, Blood Viscosity
- Creator:
- Kwaan, Hau C, Sakurai, Shumpei, Wang, Jun
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2003
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 14631552
- Title:
- The significance of endothelial heterogeneity in thrombosis and hemostasis
- Original Bibliographic Citation:
- Kwaan, H. C., & Samama, M. M. (2010). The significance of endothelial heterogeneity in thrombosis and hemostasis. Semin Thromb Hemost, 36(3), 286-300. doi:10.1055/s-0030-1253451
- Abstract:
- The endothelium is recognized today as a functional and dynamic component of the body that plays an important part in health and disease. This article briefly reviews the role of endothelium in thrombosis and hemostasis. There is a paradigm shift from one that regards the endothelium as one single entity to the concept that the endothelium isheterogeneous. Thrombotic complications in many disorders show a predilection to specific locations, despite the fact that a hypercoagulable state affects the entire body. Likewise, bleeding is more commonly encountered in certain anatomical locations than in others. Recent observations of the heterogeneous distribution of coagulation and fibrinolytic factors in the endothelium and the adaptation of the endothelium to various stimuli may provide an explanation for the diverse phenotypes. Recognition of this changing paradigm is helpful to for the diagnosis and management of bleeding and thrombotic complications. It also helps in the understanding of the pathogenesis of many bleeding and thrombotic disorders, and in the development of new drug designs for site-specific therapy.
- Keyword:
- hematology
- Subject: MESH:
- Endothelium, Thrombosis, Hemostasis
- Creator:
- Kwaan, Hau C, Samama, Meyer M.
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2010
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 20490979
- Title:
- From fibrinolysis to the plasminogen-plasmin system and beyond : a remarkable growth of knowledge, with personal observations on the history of fibrinolysis
- Original Bibliographic Citation:
- Kwaan, H. C. (2014). From fibrinolysis to the plasminogen-plasmin system and beyond: a remarkable growth of knowledge, with personal observations on the history of fibrinolysis. Semin Thromb Hemost, 40(5), 585-591. doi:10.1055/s-0034-1383545
- Abstract:
- Great advances have been made in our understanding of the fibrinolytic system from the initial discovery of proteolysis of fibrin by plasmin to the multifaceted and complex role of the plasminogen-plasmin (P-P) system. We now know that the P-P system is composed of several serine proteases and their inhibitors (serpins). This system is involved in many physiological functions, including embryogenesis, cell migration, and wound healing. They also play an important role in the pathogenesis of many diseases, including atherosclerosis, obesity, cancer, and even autoimmune disorders, and neuronal degeneration. Knowledge of their role in cancer enables their use as a prognostic factor. Therapeutic use of various forms of proteases derived from this system has been employed as thrombolytic agents. In addition, small molecules designed to inhibit many of the components of the P-P system are now available for clinical trial, aimed at treatment of these various disorders. The history of such remarkable development of our knowledge on fibrinolysis is reviewed in this article.
- Keyword:
- hematology
- Subject: MESH:
- Fibrinolysis, Plasminogen, Plasminogen Activators, Plasminogen Activator Inhibitor 1
- Creator:
- Kwaan, Hau C
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2014-07
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 25000957
- Title:
- An IgM circulating anticoagulant with factor VIII inhibitory activity
- Original Bibliographic Citation:
- McKelvey, E. M., & Kwaan, H. C. (1972). An IgM Circulating Anticoagulant with Factor VIII Inhibitory Activity. Annals of Internal Medicine, 77(4), 571-575. doi:10.7326/0003-4819-77-4-571
- Abstract:
- An acquired IgM type L inhibitor factor VIII was identified in a 63-year-old man who presented with a 2-year history of arthralgia and occasional Raynaud's phenomenon. The patient has shown no evidence of underlying malignancy, drug sensitivity, collagen disease, Waldenstrcom's macroglobulinemia, or other overt dysproteinemia. The inhibitor was initially present in high titer (1:1200) and was not corrected in vitro with either porcine factor VIII or human cryoprecipitate. However, inhibitor activity was suppressed by specific antiserums to anti-human IgM and type L light polypeptide chains and by reduction and alkylation of the purified IgM antibody. Treatment with chlorambucil was accompanied by a reduction in the patient's serum anti-factor VIII activity.
- Keyword:
- hematology
- Subject: MESH:
- Immunoglobulin M, Factor VIII, Blood Coagulation Disorders, Chlorambucil
- Creator:
- McKelvey, Eugene M., Kwaan, Hau C
- Publisher:
- American College of Physicians, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 1972-10
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Title:
- Hemostatic dysfunction in liver diseases
- Original Bibliographic Citation:
- Lisman, T., & Kwaan, H. C. (2015). Hemostatic Dysfunction in Liver Diseases. Semin Thromb Hemost, 41(5), 445-446. doi:10.1055/s-0035-1550441
- Keyword:
- hematology
- Subject: MESH:
- Hemostasis, Liver Diseases
- Creator:
- Lisman, Ton, Kwaan, Hau C
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 26126004
- Title:
- The hyperviscosity syndromes
- Original Bibliographic Citation:
- Kwaan, H. C., & Bongu, A. (1999). The hyperviscosity syndromes. Semin Thromb Hemost, 25(2), 199-208. doi:10.1055/s-2007-994921
- Abstract:
- Impaired blood flow due to abnormal rheologic characteristics results in a multiplicity of clinical manifestations, collectively termed the hyperviscosity syndrome. A basic knowledge of the principles of rheology is important in the understanding of its pathophysiology, especially the relationship between viscosity and flow conditions. The flow characteristics in different types of blood vessels are also determinants in the location of the clinical manifestation. The syndrome can occur in a wide variety of diseases and is best grouped according to the causative element or elements in blood. Abnormalities in the cellular components of blood can occur in the quantity and the quality of erythrocytes, leukocytes, and platelets. Abnormal plasma components can also be in both the quantity and quality of the plasma proteins. Clinical manifestations are the result of vascular occlusion, especially in the microcirculation. The altered rheologic characteristics of either the cellular or the protein component may be temperature dependent, being abnormal only at temperatures below 37 degrees C, so that only the cooler parts of the body are affected. The management of these conditions should be primarily directed at the removal of the abnormal component. At the same time, it should be accompanied by measures that can control the production of the causative element.
- Keyword:
- hematology
- Subject: MESH:
- Blood Viscosity, Erythrocytes, Abnormal , Leukocytes, Blood Platelets, Plasma
- Creator:
- Kwaan, Hau C, Bongu, Anurekha
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 1999
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 10357087
- Title:
- Nitric oxide, coagulation and cancer
- Original Bibliographic Citation:
- Derman, A. B., Kwaan, C. H., Elbatarny, M., & Othman, M. (2015). Nitric Oxide, Coagulation and Cancer. In B. Bonavida (Ed.), Nitric Oxide and Cancer: Pathogenesis and Therapy (pp. 281-295). Cham: Springer International Publishing.
- Keyword:
- cancer
- Subject: MESH:
- Neoplasms, Blood Coagulation, Fibrinolysis, Nitric Oxide, Plasminogen Activator Inhibitor 1, Blood Platelets
- Creator:
- Derman, Benjamin A., Kwaan, Hau C, Elbatarny, Mark, Othman, Maha
- Publisher:
- Springer International Publishing, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Title:
- Hyperviscosity in plasma cell dyscrasias
- Original Bibliographic Citation:
- Kwaan, H. C. (2013). Hyperviscosity in plasma cell dyscrasias. Clin Hemorheol Microcirc, 55(1), 75-83. doi:10.3233/ch-131691
- Abstract:
- Plasma cell dyscrasias are characterized by a malignant clonal proliferation of plasma cells. Due to the excessive production of abnormal clonal gammaglobulins, or paraproteins, there are major hemorheologic changes in the circulation. As a result, clinical manifestations of the hyperviscosity syndrome become a major cause of morbidity and mortality. Pathogenic factors for the hyperviscosity are due both to increased plasma viscosity and to increased erythrocyte aggregation, leading to increased whole blood viscosity. These changes are dependent on the plasma concentration as well as the molecular size of the paraprotein with the threshold for onset of hyperviscosity for IgG >15 g/dl, for polymerized IgG3 >4-5 g/dl, for IgA >10-11 g/dl; for polymerized IgA >6-7 g/dl and for IgM >3 g/dl. Correspondingly, the incidence of symptomatic hyperviscosity in Waldenstrom's macroglobulinemia is 10-30%, while that in IgG myeloma is 2-6%. Clinically, the syndrome has neurologic features of headache and dizziness, visual changes, renal failure, and cardiac failure from increased plasma volume. Thrombotic complications are frequent. Paradoxically, there can be bleeding complications due to impairment of platelet function. Removal of the paraprotein by plasma exchange (plasmapheresis) can effectively reduce the hyperviscosity. Long-term control of paraprotein production can be achieved by chemotherapy. The early recognition of the symptoms of hyperviscosity, confirmed by laboratory findings of increased paraproteins and of increased blood viscosity, is essential for the proper management of this group of disorders.
- Keyword:
- dyscrasias
- Subject: MESH:
- Paraproteinemias, Blood Viscosity, Paraproteins, Waldenstrom Macroglobulinemia
- Creator:
- Kwaan, Hau C
- Publisher:
- IOS Press, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2013
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 23455837
- Title:
- Thrombotic microangiopathy manifesting as thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in the cancer patient
- Original Bibliographic Citation:
- Gordon, L. I., & Kwaan, H. C. (1999). Thrombotic microangiopathy manifesting as thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in the cancer patient. Semin Thromb Hemost, 25(2), 217-221. doi:10.1055/s-2007-994923
- Abstract:
- The complication of thrombotic thrombocytopenic purpura or hemolytic uremic syndrome (TTP/HUS) can occur in cancer patients. It is characterized by a microangiopathic hemolytic anemia, severe thrombocytopenia, and renal failure. Pulmonary manifestations, especially pulmonary edema, are a common observation. Neurologic changes are also frequently seen. The etiology is unknown at this time. It has been observed in many different types of cancer and is most commonly seen in gastric adeno-carcinoma followed by carcinoma of the breast, colon, and small cell lung carcinoma. The hemolysis can be massive and is due to red cell fragmentation, as schistocytes are present in all the cases. Though immune complexes are present in the plasma, the antiglobulin (Coomb's) test is negative. Chemotherapeutic agents, especially mitomycin C, have been implicated as causative factors. There is a correlation of this complication with the cumulative dose. However, chemotherapy cannot account for all the cases as the syndrome can occur in untreated patients. It can be differentiated from disseminated intravascular coagulation by the absence of a coagulopathy. Management should consist of plasma exchange, use of a Staphyloccus aureus column (Prosorba), and control of hypertension. Because of the susceptibility to pulmonary edema, blood volume overloading should be avoided.
- Keyword:
- TTP, HUS, thrombotic microangiopathy
- Subject: MESH:
- Purpura, Thrombotic Thrombocytopenic, Hemolytic-Uremic Syndrome, Neoplasms, Hemolysis
- Creator:
- Gordon, Leo I, Kwaan, Hau C
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 1999
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 10357089
- Title:
- Ticlopidine-, Clopidogrel-, and Prasugrel-associated thrombotic thrombocytopenic purpura: a 20-year review from the Southern Network on Adverse Reactions (SOAR)
- Original Bibliographic Citation:
- Jacob, S., Dunn, B. L., Qureshi, Z. P., Bandarenko, N., Kwaan, H. C., Pandey, D. K., . . . Bennett, C. L. (2012). Ticlopidine-, clopidogrel-, and prasugrel-associated thrombotic thrombocytopenic purpura: a 20-year review from the Southern Network on Adverse Reactions (SONAR). Semin Thromb Hemost, 38(8), 845-853. doi:10.1055/s-0032-1328894
- Abstract:
- Thienopyridine derivatives (ticlopidine, clopidogrel, and prasugrel) are the primary antiplatelet agents. Thrombotic thrombocytopenic purpura (TTP) is a rare drug-associated syndrome, with the thienopyridines being the most common drugs implicated in this syndrome. We reviewed 20 years of information on clinical, epidemiologic, and laboratory findings for thienopyridine-associated TTP. Four, 11, and 11 cases of thienopyridine- associated TTP were reported in the first year of marketing of ticlopidine (1989), clopidogrel (1998), and prasugrel (2010), respectively. As of 2011, the FDA received reports of 97 ticlopidine-, 197 clopidogrel-, and 14 prasugrel-associated TTP cases. Severe deficiency of ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13) was present in 80% and antibodies to 100% of these TTP patients on ticlopidine, 0% of the patients with clopidogrel-associated TTP (p < 0.05), and an unknown percentage of patients with prasugrel-associated TTP. TTP is associated with use of each of the three thienopyridines, although the mechanistic pathways may differ.
- Keyword:
- Ticlopidine, Clopidogrel, Prasugrel
- Subject: MESH:
- Ticlopidine, Purpura, Thrombotic Thrombocytopenic, Thienopyridines
- Creator:
- Jacob, Sony, Dunn, Brianne L., Qureshi, Zaina, 1982-, Bandarenko, Nicholas, Kwaan, Hau C, Pandey, Dilip K., McKoy, June M, Barnato, Sara E., Winters, Jeffrey L., Cursio, John F., Weiss, Ivy M, Raife, Thomas J., Carey, Patricia M., Sarode, Ravindra, Kiss, Joseph E., Danielson, Constance, Ortel, Thomas L. (Thomas Lee), 1957-, Clark, William F., Rock, Gail, Matsumoto, Masanori, 1935-, Fujimura, Yoshihiro, Zheng, X. Long, Chen, Hao, Chen, Fei, Armstrong, John M., Raisch, Dennis W., Bennet, Charles L.
- Publisher:
- Thieme Medical Publishers, Inc., DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2012-10-30
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Original Identifier:
- (PMID) 23111862
- Title:
- Galter Library's disappearing stacks
- Description:
- Originally published in: Nickisch Duggan, Heidi M, Berendsen, Mark A, Zmaczynski, Mary Anne. Galter Librarys Disappearing Stacks. Against the Grain. 2015; 27(2):24. http://www.against-the-grain.com/. PDF of article posted with publisher's permission, Article in special issue of Against the Grain, entitled: "Disappearing [print] Stacks No Books, but Everything Else".
- Original Bibliographic Citation:
- Nickisch Duggan, Heidi M., Berendsen, Mark A., Zmaczynski, Mary Anne. Galter Library's Disappearing Stacks. Against the Grain. 2015; 27(2):24.
- Keyword:
- medical libraries, Galter Health Sciences Library, Oak Grove Library Center
- Subject: MESH:
- Libraries, Medical
- Subject: LCSH:
- Medical libraries--Collection development, Collection management (Libraries), Library materials
- Creator:
- Nickisch-Duggan, Heidi, Berendsen, Mark A, Zmaczynski, Mary Anne
- Publisher:
- Against the Grain, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2015
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Title:
- Subject semantic interoperabilty
- Description:
- Final Report of the Subcommittee on Semantic Interoperability to the ALCTS Subject Analysis Committee.
- Original Bibliographic Citation:
- Subject Semantic Interoperability : Final Report of the Subcommittee on Semantic Interoperability to the ALCTS Subject Analysis Committee (Chicago : Association for Library Collections and Technical Services, 2006)
- Abstract:
- An information system managing its own subject access for a single resource can relatively easily produce a successful database. However, there is an increasing need to access multiple resources in multiple languages or with multiple thesauri or controlled vocabularies. To a point, multiple controlled vocabularies and knowledge organization systems (KOS) can be made to interoperate. However, without appropriate design, the resulting search results will be non-semantic and of little value to users. Given that converging information systems with theiridiosyncratic histories and social functions are likely to produce overlaps, seams, and gaps in the compositewhole, the Subject Analysis Committee formed the Subcommittee on Semantic Interoperability to investigate what techniques are currently being employed by developers to minimize loss of meaning and create true semantic interoperability.
- Keyword:
- Subject Semantic Interoperability, Controlled vocabularies
- Subject: MESH:
- Information Systems, Vocabulary, Controlled
- Subject: LCSH:
- Information storage and retrieval systems, Subject headings
- Creator:
- Association for Library Collections and Technical Services. Subject Analysis Committee. Subcommittee on Semantic Interoperability
- Contributor:
- Harken, Shelby E., Olson, Tony (Librarian), 1938-
- Publisher:
- Association for Library Collections and Technical Services, DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2006
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Report
- Title:
- An overview of research and evaluation designs for dissemination and implementation
- Original Bibliographic Citation:
- Brown, C. H., Curran, G., Palinkas, L. A., Aarons, G. A., Wells, K. B., Jones, L., Collins, L. M., Duan, N., Mittman, B. S., Wallace, A., Tabak, R. G., Ducharme, L., Chambers, D., Neta, G., Wiley, T., Landsverk, J., Cheung, K., & Cruden, G. (in press). An overview of research and evaluation designs for dissemination and implementation. Annual Review of Public Health. doi: 10.18131/G35W23 (pre-print).
- Abstract:
- Background: There is a wide variety of dissemination and implementation designs now being used to evaluate and improve health systems and outcomes. Methods: This paper is one product of a design workgroup formed in 2013 by the National Institutes of Health (NIH) in order to address dissemination and implementation research, and whose members represented diverse methodologic backgrounds, content focus areas, and health sectors. These experts integrated their collective knowledge on implementation designs with searches of published evaluations of implementation strategies. Results: This paper describes designs for the traditional translational pipeline, which builds on existing efficacy and effectiveness trials to examine how an evidence-based clinical/prevention intervention is adopted, scaled up, and sustained in community or service delivery systems. A range of randomized and non-randomized designs is used in this approach that focuses on producing generalizable knowledge about implementation and dissemination.
- Keyword:
- implementation, scale up, implementation trial, adaptation, fidelity, sustainment
- Subject: MESH:
- Information Dissemination, Research Design, Translational Research, Biomedical
- Creator:
- Brown, C Hendricks, Curran, Geoffrey, Palinkas, Lawrence A., Aarons, Gregory A., Wells, Kenneth B., 1948-, Jones, Loretta, Collins, Linda M., Duan, Naihua, 1949-, Mittman, Brian S., Wallace, Andrea, Tabak, Rachel G., Ducharme, Lori, Chambers, David, Neta, Gila, Wiley, Tisha, Landsverk, John, Cheung, Ken, Cruden, Gracelyn Howell
- Publisher:
- Annual Review of Public Health, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2016
- Rights:
- http://creativecommons.org/licenses/by-nc-nd/3.0/us/
- Resource Type:
- Journal Article
- Title:
- Charles and William Mayo
- Description:
- Oil on canvas portrait of Charles H. Mayo and William J. Mayo by artist Gerald Cassidy. B/w photo of framed portrait, measuring 221 cm H x 180 cm W x 8 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. Accompanying plaque, measuring 10.2 cm H x 15.2 cm W x 2.5 cm D, reads: Charles H. Mayo, MD., M.A., LL.D., Sc.D. Class of 1888, Northwestern University Medical School (standing) William J. Mayo, M.D., M.A., Sc.D., LL.D 1928, Sc.D., Northwestern University). , Portrait was commissioned by the Mayo brothers in 1925 and presented to Northwestern University in 1929. The portrait was formally dedicated in 1930 and was displayed in the Archibald Church Library at Northwestern University Medical School, now Galter Health Sciences Library. (source: article by Ron Sims, entitled, "Return of the Mayo Brothers' Portrait to Galter Library" in Library Notes #56, September 2009)
- Original Bibliographic Citation:
- Cassidy, Gerald. Mayo Brothers. 1929. Oil on canvas. Feinberg School of Medicine, Chicago, Illinois.
- Keyword:
- Feinberg School of Medicine, Northwestern University Medical School, art, artwork, paintings
- Subject: MESH:
- Physicians, Surgeons
- Subject: Name:
- Mayo, Charles H. (Charles Horace), 1865-1939, Mayo, William James, 1861-1939
- Creator:
- Cassidy, Gerald, 1869-1934
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1929
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
- Title:
- Chicago Medical College , Chicago Medical College (1870-1890), Chicago Medical College (26th and Prairie Avenue)
- Description:
- The Chicago Medical College (now called Northwestern University, Feinberg School of Medicine) at its third location, Twenty-Sixth Street and Prairie Avenue: 1870-1893. (Photograph and description can be found on page 76 of: Northwestern University Medical School 1859-1979 / Leslie B. Arey, Northwestern University: Evanston and Chicago, revised and extended edition).
- Keyword:
- Northwestern University Medical School, Feinberg School of Medicine
- Subject: MESH:
- Schools, Medical
- Subject: LCSH:
- College buildings--Illinois
- Subject: Geographic Name:
- Chicago (Ill.)
- Subject: Name:
- Chicago Medical College
- Creator:
- Creator not identified
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Photographs
- Title:
- Microscopical laboratory in the Twenty-Sixth Street building
- Description:
- Microscopical laboratory in the Twenty-Sixth Street building. The Chicago Medical College (now called Northwestern University, Feinberg School of Medicine) was located in its third location, Twenty-Sixth Street and Prairie Avenue, from 1870-1893. (Photograph and its description can be found on p. 79 of: Northwestern University Medical School 1859-1979 / Leslie B. Arey, Northwestern University: Evanston and Chicago, revised and extended edition).
- Keyword:
- Feinberg School of Medicine, Northwestern University Medical School
- Subject: MESH:
- Schools, Medical, Laboratories, Students, Medical
- Subject: LCSH:
- Microscopes
- Subject: Geographic Name:
- Chicago (Ill.)
- Subject: Name:
- Chicago Medical College
- Creator:
- Creator not identified
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1800/1899
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Photographs
- Title:
- Anatomy class in amphitheater at the Twenty-Sixth Street building
- Description:
- Anatomy class in amphitheater at the Twenty-Sixth Street building, 1885. The Chicago Medical College (now called Northwestern University, Feinberg School of Medicine) was located in its third location, Twenty-Sixth Street and Prairie Avenue, from 1870-1893. (Photograph and its description can be found on p. 79 of: Northwestern University Medical School 1859-1979 / Leslie B. Arey, Northwestern University: Evanston and Chicago, revised and extended edition).
- Keyword:
- Northwestern University Medical School, Feinberg School of Medicine
- Subject: MESH:
- Schools, Medical, Students, Medical, Education, Medical
- Subject: Geographic Name:
- Chicago (Ill.)
- Subject: Name:
- Chicago Medical College
- Creator:
- Creator not identified
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1885
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Photographs
447. Exploring the History of Medicine, Or five thousand years of medical history in five weeks, 2012
- Title:
- Exploring the History of Medicine, Or five thousand years of medical history in five weeks, 2012
- Description:
- A five part annual seminar that was offered as an elective to the Feinberg School of Medicine M1 and M2 classes between 2004 and 2013. The seminars were coordinated by the Galter Health Sciences Library, and included introductory highlights about the history of medicine, and featured rare books and artifacts from the Galter Library's Special Collections. Ron Sims, the Special Collections Librarian, led the seminars which focused on presentations by students. During the early years, librarians James Shedlock and Ramune K. Kubilius also helped to facilitate the seminar. The slides in these presentations were shown during the 2012 seminar.
- Abstract:
- Using the rich resources of the Galter Health Sciences Library, this seminar explored the history of medicine through the examination and review of primary texts. Students chose a disease or health issue and traced it back from contemporary times to the 15th or 16th century, focusing on the connection between the literature of that period and what we know today. Each student reported on at least one primary text from the century that is that week's focus. There was at least one PowerPoint presentation by each student.
- Keyword:
- Medical Education, Curriculum, History of Medicine
- Subject: MESH:
- Education, Medical, History of Medicine
- Creator:
- Sims, Ronald H
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Location:
- Chicago, Illinois, United States
- Language:
- English
- Date Created:
- 2012
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Presentation
- Title:
- DigitalHub: Preserving Your Work Using NM's Repository
- Keyword:
- Institutional Repository, Galter Health Sciences Library
- Subject: MESH:
- Libraries, Digital
- Subject: LCSH:
- Institutional repositories
- Subject: Name:
- Feinberg School of Medicine
- Creator:
- Ilik, Violeta
- Contributor:
- Hebal, Piotr
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2016-04-12
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Presentation
449. Nicholas Senn
- Title:
- Nicholas Senn
- Description:
- Oil on canvas portrait of Dr. Nicholas Senn by artist Sister Mary Matthew. Photo of framed portrait, measuring 96 cm H x 83 cm W x 10 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. The plaque, measuring 10.2 cm H x 15.2 W x 2.5 cm D, reads: Nichols Senn, M.D. Class of 1868 Northwestern University Medical School. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: p. 70 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- Feinberg School of Medicine, art, artwork, Northwestern University, paintings, portraits
- Subject: MESH:
- Faculty, Medical, Physicians, Surgeons
- Subject: LCSH:
- Medical colleges--Faculty
- Subject: Geographic Name:
- Chicago (Ill.)
- Subject: Name:
- Senn, Nicholas, 1844-1908, Rush Medical College
- Creator:
- Matthew, Mary, Sister
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
450. Robert Laughlin Rea
- Title:
- Robert Laughlin Rea
- Description:
- Oil on canvas portrait of Dr. Robert Laughlin Rea by artist Carol Aus. Photo of framed portrait, measuring 131 cm H x 42 cm W x 107 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. The plaque, measuring 10.2 cm H x 15.2 W x 2.5 cm D, reads: Robert Laughlin Rea, M.D., Professor of Anatomy, 1878 to 1882 Northwestern University Medical School. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: p. 70 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Feinberg School of Medicine, Northwestern University, paintings, portraits, Rea, Robert Laughlin, 1827-1899
- Subject: MESH:
- Schools, Medical--history, Faculty, Medical, Physicians
- Subject: LCSH:
- Medical colleges--Faculty
- Subject: Geographic Name:
- Chicago (Ill.)
- Subject: Name:
- Chicago Medical College
- Creator:
- Aus, Carol, 1878-1934
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
451. Otto Leopold Schmidt
- Title:
- Otto Leopold Schmidt
- Description:
- Oil on canvas portrait of Dr. Otto Leopold Schmidt by artist E. S. Klempner. Photo of framed portrait, measuring 99 cm H x 83 cm W x 10 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. The plaque, measuring 10.2 cm H x 15.2 W x 2.5 cm D, reads: Otto Leopold Schmidt, M.D. Instructor of Medicine, 1889-1892 Northwestern University Medical School. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. Dr. Schmidt graduated from the medical school in 1895 and became a member of the faculty in 1899. (Sources: pp. 64-66 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School & Q Bull Northwest Univ Med Sch. 1942 Summer, 16(2):158)
- Keyword:
- art, artwork, Feinberg School of Medicine, Northwestern University, paintings, portraits, Schmidt, Otto Leopold, 1863-1935
- Subject: MESH:
- Faculty, Medical, Schools, Medical--history, Physicians
- Subject: LCSH:
- Medical colleges--Faculty
- Subject: Geographic Name:
- Chicago (Ill.)
- Subject: Name:
- Chicago Medical College, Northwestern University (Evanston, Ill.). Medical School
- Creator:
- Klempner, Ernest S., 1867-1962
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
452. David Rutter
- Title:
- David Rutter
- Description:
- Oil on canvas portrait of Dr. David Rutter by artist Marie G. Cameron. B/W photo of framed colored portrait, measuring 93 cm H x 81 cm W x 10 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. The plaque, measuring 10.2 cm H x 15.2 W x 2.5 cm D. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Founder) One of the organizers of the Medical Department, Lind University (later the Chicago Medical College), 1859. Professor of Obstetrics, later Emeritus Professor of Obstetrics, Northwestern University Medical School, 1859-65. (Source: p. 70 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Feinberg School of Medicine, Northwestern University, paintings, portraits, Rutter, David, 1800-1865
- Subject: MESH:
- Schools, Medical--history, Faculty, Medical, Physicians
- Subject: LCSH:
- Medical colleges--Faculty
- Creator:
- Cameron, Marie G. (Gelon), 1862-1949
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
453. VIVO
- Title:
- VIVO
- Keyword:
- VIVO, RDF, Open Data, Visualization
- Creator:
- Friedman, Paul
- Contributor:
- Friedman, Paul
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Rights:
- http://creativecommons.org/publicdomain/zero/1.0/
- Resource Type:
- Poster
- Title:
- Case: A Clinical Trial of Fetal Surgery
- Keyword:
- research ethics, human subjects research, research with pregnant women, informed consent
- Subject: MESH:
- Ethics, Research, Clinical Trials as Topic--ethics, Fetus--surgery
- Subject: LCSH:
- Research--Moral and ethical aspects
- Creator:
- Moran, Maureen B
- Contributor:
- Moran, Maureen B
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc-nd/3.0/us/
- Resource Type:
- Clinical Trial
455. Isaac Arthur Abt
- Title:
- Isaac Arthur Abt
- Description:
- Oil on canvas portrait of Dr. Isaac Abt by artist John Doctoroff. Photo of framed portrait, measuring 95 cm H x 83 cm W x 8 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. The plaque, measuring 10.2 cm H x 15.2 W x 2.5 cm D, reads: Isaac Arthur Abt, M.D., Class of 1891, Professor of Pediatrics, 1909 to 1955 Northwestern University Medical School. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: pp. 78 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Feinberg School of Medicine, Northwestern University, paintings, portraits
- Subject: MESH:
- Schools, Medical--history, Faculty, Medical, Physicians
- Subject: LCSH:
- Medical colleges--Faculty
- Subject: Geographic Name:
- Chicago (Ill.)
- Subject: Name:
- Abt, Isaac A. (Isaac Arthur), 1867-1955, Northwestern University (Evanston, Ill.). Medical School
- Creator:
- Doctoroff, John, 1893-1970
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
456. Edmund Andrews
- Title:
- Edmund Andrews
- Description:
- Oil on canvas portrait of Dr. Edmund Andrews by unknown. Photo of framed portrait, measuring 85 cm H x 70 cm W x 9 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. The plaque, measuring 10.2 cm H x 15.2 W x 2.5 cm D, reads: Edmund Andrews, M.D., M.A., Founder and Professor of Surgery, 1859 to 1904 Northwestern University Medical School. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: pp. 68 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- artwork, Feinberg School of Medicine, photograph, portrait
- Subject: MESH:
- Faculty, Medical, Surgeons
- Subject: Name:
- Andrews, Edmund, 1824-1904
- Creator:
- unknown
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
- Title:
- Hack the link resolver: A DIY, tailored approach to full text linking in PubMed
- Description:
- PowerPoint slides and notes from a short talk given at the 2016 Electronic Resources & Libraries (ER&L) Conference in Austin, TX.
- Abstract:
- Link resolvers are essential research tools. Unfortunately, they do not always integrate well with particular databases and discovery services. This session will discuss Northwestern University's decision to eschew the Alma resolver in favor of a DIY solution tailored to PubMed, resulting in improved usability and accuracy of full text linking.
- Keyword:
- Link Resolver, OpenURL, PMID, Alma, PubMed, NCBI, OutsideTool, ER&L
- Subject: MESH:
- Library Technical Services, PubMed, Serial Publications
- Subject: LCSH:
- Medical libraries, Electronic journals, Technical services (Libraries), Electronic information resources, Web services--Library applications, Library resources
- Creator:
- Shank, Jonathan P
- Contributor:
- Hebal, Piotr, Stirnaman, Jason T Todd
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Location:
- Austin, Texas, United States
- Language:
- English
- Date Created:
- 2016-04-04
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Presentation
458. Edmund Janes Doering
- Title:
- Edmund Janes Doering
- Description:
- Oil on canvas portrait of Dr. Edmund Janes Doering by artist Tunis Ponsen. Photo of framed portrait, measuring 95 cm H x 80 cm W x 8 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. Dr. Doering: MD., 1874; M.Sc., 1916. Northwestern University Medical School.The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: pp. 72 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Feinberg School of Medicine, Northwestern University, paintings, portraits, Doering, Edmund Janes, 1856-
- Subject: MESH:
- Schools, Medical--history, Faculty, Medical
- Subject: LCSH:
- Medical colleges--Faculty
- Subject: Geographic Name:
- Chicago (Ill.)
- Creator:
- Ponsen, Tunis, 1891-1968
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
- Title:
- Bas relief of Archibald Church
- Description:
- Brass bas-relief of Dr. Archibald Church designed by Leonard Crunelle. Photo of bas-relief housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. Archibald Church was Professor of Nervous and Mental Diseases. The bas-relief was erected in the Archibald Church Medical Library by order of the Board of Trustees of Northwestern University and unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927. (Source: pp. 38-39 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Northwestern University, Feinberg School of Medicine
- Subject: MESH:
- Faculty, Medical, Physicians
- Subject: LCSH:
- College teachers
- Subject: Name:
- Church, Archibald, 1861-1952
- Creator:
- Crunelle, Leonard, 1872-1944
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 1927
- Rights:
- http://creativecommons.org/licenses/by-sa/3.0/us/
- Resource Type:
- Portraits
460. Ralph N. Isham
- Title:
- Ralph N. Isham
- Description:
- Oil on canvas portrait of Ralph N. Isham by artist Ferris. Photo of framed portrait, measuring 95 cm H x 80 cm W x 8 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. Plaque, measuring 10.2 cm x 15.2 cm x 2.5 cm, reads: Ralph N. Isham, M.D., A.M., L.L.D. Founder and Professor of Surgery, 1859-1904 Northwestern University Medial School.The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: pp. 52-54 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Northwestern University Medical School, paintings
- Subject: MESH:
- Faculty, Medical, Physicians, Surgeons
- Subject: LCSH:
- College teachers
- Subject: Name:
- Isham, Ralph N., 1831-1904
- Creator:
- Creator not identified
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1927
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
461. John Harper Long
- Title:
- John Harper Long
- Description:
- Oil on canvas portrait of John Harper Long by artist Arvid Nyholm. Photo of framed portrait, measuring 94 cm H x 81 cm W x 6 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. Plaque, measuring 10.2 cm x 15.2 cm x 2.5 cm, reads: John Harper Long, M.S., Sc.D. Dean 1913-1917 Northwestern University School of Pharmacy. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: pp. 62-63 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Northwestern University Medical School, paintings
- Subject: MESH:
- Faculty, Medical
- Subject: LCSH:
- Deans (Education), College teachers, Chemists
- Subject: Name:
- Long, John Harper, 1856-1918
- Creator:
- Nyholm, Arvid
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1927
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
- Title:
- John Hamilcar Hollister
- Description:
- Oil on canvas portrait of Dr. James Hamilcar Hollister by artist Sister Mary Pius. Photo of framed portrait, measuring 86 cm H x 71 cm W x 8 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. The plaque, measuring 10.2 cm H x 15.2 W x 2.5 cm D reads: James Hamilcar Hollister, MD Founder and Professor of Medicine 1859-1895 Northwestern University Medical School. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: p. 47-49 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Northwestern University Medical School, Feinberg School of Medicine, paintings
- Subject: MESH:
- Faculty, Medical
- Subject: LCSH:
- College teachers, Physicians
- Subject: Name:
- Hollister, John Hamilcar, 1824-1911
- Creator:
- Pius, Mary, Sister
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1927
- Rights:
- http://creativecommons.org/licenses/by-sa/3.0/us/
- Resource Type:
- Portraits
- Title:
- Nathan Smith Davis, II
- Description:
- Oil on canvas portrait of Dr. Nathan Smith Davis II by artist Stanisio. Photo of framed portrait, measuring 133 cm H x 108 cm W x 10 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. The plaque, attached to the portrait frame and measuring 5.1 cm H x 10.2 W, reads: Nathan S Davis II, A.M., M.D. Faculty Member Department of Pathology 1884-1920 Dean of the Medical School 1902-1908. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: p. 74 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Northwestern University Medical School, Feinberg School of Medicine, paintings
- Subject: MESH:
- Faculty, Medical, Physicians
- Subject: LCSH:
- Deans (Education), College teachers
- Subject: Name:
- Davis, N. S. (Nathan Smith), 1858-1920
- Creator:
- Stanisio
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1927
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
464. Franklin H. Martin
- Title:
- Franklin H. Martin
- Description:
- Oil on canvas portrait of Dr. Franklin H. Martin by artist Alois DeLug. Photo of framed portrait, measuring 111 cm H x 95 cm W x 10 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. The plaque, measuring 10.2 cm H x 15.2 W x 2.5 cm, reads: Franklin H. Martin, M.D., LL.D., D.P.H., Sc.D. Class of 1880 Northwestern University Medical School. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: p. 60-61 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Northwestern University Medical School, Feinberg School of Medicine, paintings
- Subject: MESH:
- Faculty, Medical, Physicians
- Subject: LCSH:
- College teachers, Gynecologists
- Subject: Name:
- Martin, Franklin H. (Franklin Henry), 1857-1935
- Creator:
- Delug, Alois, 1859-1930
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1927
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
465. John Ridlon
- Title:
- John Ridlon
- Description:
- Oil on canvas portrait of John Ridlon by artist Carl Bohnen. Photo of framed portrait, measuring 144 cm H x 123 cm W x 10 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. Professor of Orthopaedic Surgery, Northwestern University Medical School, 1892-1908 and Northwestern Women's Medical School, 1898-1902. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: p. 71 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Northwestern University Medical School, Feinberg School of Medicine, paintings
- Subject: MESH:
- Faculty, Medical, Surgeons
- Subject: LCSH:
- College teachers
- Subject: Name:
- Ridlon, John, 1852-1936
- Creator:
- Bohnen, Carl A., 1872-1951
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1927
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
- Title:
- Family-centered positive behavior support interventions in early childhood to prevent obesity
- Abstract:
- We propose that parents use of positive behavior support (PBS) strategies in early childhood, which include proactively structuring environments to support and positively reinforce healthy dietary and physical activity behaviors, is critical to preventing pediatric obesity, particularly among low-income, ethnic minority children. Existing evidence-based family-centered preventive interventions effectively impact parents use of PBS strategies. Enhancing these programs to more directly target the key mechanisms of change specific to promoting childrens healthy lifestyle behaviors could serve as the foundation for the next generation of effective protocols for preventing pediatric obesity. Two established programs that target PBS that can be feasibly implemented in a variety of service delivery systems using a multi-tiered, adaptive approach and the next steps of translation are discussed.
- Keyword:
- obesity, prevention
- Subject: MESH:
- Pediatric Obesity, Behavior Therapy, Child
- Creator:
- Smith, Justin D., St. George, Sara M. (Sara Mijares), Prado, Guillermo
- Publisher:
- Wiley, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2016
- Rights:
- http://creativecommons.org/licenses/by-nc-nd/3.0/us/
- Resource Type:
- Journal Article
467. Nathan Smith Davis
- Title:
- Nathan Smith Davis
- Description:
- Oil on canvas portrait of Dr. Nathan Smith Davis by artist George P. A. Healy. Photo of framed portrait, measuring 91 cm H x 80 cm W x 8 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. Nathan Smith Davis, M.D., A.M., LL.D. was a Founder and Dean of the Medical School 1872-1898. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: p. 40-42 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Northwestern University Medical School, Feinberg School of Medicine, paintings
- Subject: MESH:
- Faculty, Medical, Physicians
- Subject: LCSH:
- Deans (Education), College teachers
- Subject: Name:
- Davis, N. S. (Nathan Smith), 1817-1904
- Creator:
- Healy, G. P. A. (George Peter Alexander), 1813-1894
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1927
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
468. William Heath Byford
- Title:
- William Heath Byford
- Description:
- Oil on canvas portrait of Dr. William Byford Heath by artist Edith White. Photo of framed portrait, measuring 88 cm H x 76 cm W x 8 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. Plaque, measuring 10.2 cm H x 15.2 cm W x 2.5 cm D reads: William Heath Byford, MD Founder and Professor of Obstetrics and Diseases of Women and Children 1859-1890 Northwestern University Medical School. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: p. 45-46 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Northwestern University Medical School, Feinberg School of Medicine, paintings
- Subject: MESH:
- Faculty, Medical, Physicians
- Subject: LCSH:
- College teachers, Gynecologists
- Subject: Name:
- Byford, William Heath, 1817-1890
- Creator:
- White, Edith, 1855-1946
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1927
- Rights:
- http://creativecommons.org/licenses/by-sa/3.0/us/
- Resource Type:
- Portraits
469. Emilius Clark Dudley
- Title:
- Emilius Clark Dudley
- Description:
- Oil on canvas portrait of Dr. Emilius Clark Dudley by artist Katherine Dudley. B/W photo of framed colored portrait, measuring 99 cm H x 79 cm W x 6 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. Plaque, attached to portrait and measuring 2.5 cm H x 10.2 cm W reads: Emilius Clark Dudley Department of Gynecology 1882-1928 Northwestern University Medical School. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: p. 55-56 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Feinberg School of Medicine, Northwestern University Medical School, paintings
- Subject: MESH:
- Faculty, Medical, Physicians
- Subject: LCSH:
- Gynecologists, College teachers
- Subject: Name:
- Dudley, E. C. (Emilius Clark), 1850-1928
- Creator:
- Dudley, Katherine
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1927
- Rights:
- http://creativecommons.org/licenses/by-sa/3.0/us/
- Resource Type:
- Portraits
470. Thomas James Watkins
- Title:
- Thomas James Watkins
- Description:
- Oil on canvas portrait of Dr. Thomas James Watkins by artist Tom Jones. B/W photo of framed colored portrait, measuring 100 cm H x 80 cm W x 6 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. Plaque, attached to portrait and measuring 2.5 cm H x 10.2 cm W reads: Thomas Jones Watkins Department of Gynecology 1890-1925. The portrait was unveiled at the dedication of the Montgomery Ward Memorial Building in June 1927 and added to the collection of the Archibald Church Library. (Source: p. 75 IN: Dedication of the Montgomery Ward Memorial Building, Northwestern University Medical School, Alexander McKinlock Memorial Campus, Chicago, c.1929, Northwestern University Medical School)
- Keyword:
- art, artwork, Feinberg School of Medicine, Northwestern University Medical School, paintings
- Subject: MESH:
- Faculty, Medical, Physicians
- Subject: LCSH:
- College teachers, Gynecologists
- Subject: Name:
- Watkins, T. J. (Thomas James), 1863-1925
- Creator:
- Jones, Tom
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Date Created:
- 1927
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
- Title:
- Statistical considerations in basic science sex inclusive research
- Keyword:
- Sex Inclusive Research
- Subject: MESH:
- Biostatistics, Statistics as Topic, Sex, Research
- Creator:
- Scholtens, Denise M, Welty, Leah J
- Contributor:
- Woodruff, Teresa K
- Publisher:
- Northwestern University (Evanston, Ill.). Clinical and Translational Sciences Institute, Northwestern University (Evanston, Ill.). Robert H. Lurie Cancer Center, DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2016-05-19
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Guideline
- Title:
- The mosaic of translation: an analysis of translational medicine publications
- Description:
- Poster presented at the Medical Library Association Annual Conference, Toronto, ON 2016. Presented on 05/10/2016.
- Abstract:
- Objective: Research impact and evaluation services are incredibly important in the area of translational medicine. One method for evaluation is publication analysis, which plays a valuable role in helping an institution gain insights about its research and clinical activities that might not be discernible from other means, including some of the available institution-level data stores. Methods: We used publication analysis and information visualization to evaluate the outputs of translational medicine. We discussed the results of harvesting bibliographic metadata from literature databases, analyzing percentile rankings of publications, and reviewing topical trends over time. Results: We found that coverage of journals with a translational focus varies by resource. Additionally, each resource allows for differing types and quantities of exportable metadata. Publications were analyzed based on the available metadata, and visualizations were created to show the results of the publication analysis. Conclusions: The insights gained through evaluation, in particular using publication analysis, allow both investigators and the institutions to convey the benefits and impact of their research and clinical efforts to stakeholders. Publication analysis also provides valuable information that can be used for benchmarking, forecasting, and strategic planning activities.
- Keyword:
- translational science, translational medicine, citation network, CitNetExplorer, VOSViewer, Tableau, postmenopausal osteoporosis, denosumab, prolia, Medical Library Association, MLA
- Subject: MESH:
- Bibliometrics, Biomedical Research, Translational Research, Biomedical
- Creator:
- Gutzman, Karen E
- Contributor:
- Shaw, Pamela L, Mohammadi, Ehsan, Holmes, Kristi
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Location:
- Toronto, Ontario, Canada
- Language:
- English
- Date Created:
- 2016
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Poster
- Title:
- Attribution of work in the scholarly ecosystem
- Description:
- Poster presented at the FORCE 2016 Annual Conference in Portland, OR. Presented on 04/19/2016.
- Abstract:
- As research is driven forward by technological advances, the composition and structure of the research team is also evolving. Professionals from a wide array of backgrounds contribute to scientific breakthroughs and discoveries, often in ways that are not easily recognizable using traditional measures of scholarly impact. Metrics and indicators that are limited to grants and publications often cause these diverse contributions to be overlooked and undervalued. The lack of adequate representation can affect large swaths of the current scholarly ecosystem, such as career advancement, financial incentives, funding acquisition, and scholarly recognition. In this project we have outlined a list of contributor roles identified by the Force 11 Attribution Working Group. Contributor roles from existing taxonomies were leveraged (CRediT) and further enhanced with finer resolution contributor roles based on an in-depth investigation of activities and outputs. We have also collated and reviewed existing efforts on scholarly contribution taxonomies to determine their unique aspects, and how they complement each other. We review the landscape of taxonomies or systems in order to compare and contrast key types of contributions. We speculate on the objectives needed to create a contributorship model that is robust enough to cover various fields of research, and specific enough to adequately describe contribution in a meaningful way. We found there to be a diverse landscape of projects and groups working in this area, though each with its own perspective. A brief outline of the coverage, goals and relevant factors of these projects or groups is provided. Several projects were identified as being relevant to this inquiry, including Contributor Roles Taxonomy Project (CRediT), VIVO-ISF ontology, Provenance (PROV), the Becker Model and other impact frameworks, Transitive Credit, Academic Careers Understood through Measurement and Norms (ACUMEN Project), and the Scholarly Contributions and Roles Ontology (SCoRO). Additionally, several working groups were identified: Global Alliance for Genomics and Health (GA4GH), National Information Standards Organization (NISO), and the Force 11 Attribution Working Group. Through the in-depth study of different contribution roles in the scholarly process, we were able to better understand how these contributions might be structures in terms of a particular output (manuscript, dataset, etc.) and also contributions to the project as a whole. Moreover, we developed a 2-level hierarchy to enable more complete representation of these roles through major classes such as author, communication, data, IP, project and team management, regulatory administration, software development, and so on. While there are projects and ongoing efforts to better understand the diverse roles that professionals take on when contributing to the scholarly ecosystem, it is clear that more work is needed to fully explore the area of contributorship roles. Several leaders in this area have proposed projects to define an informatics infrastructure that enables the collection and dissemination on contributor attribution data to various stakeholder audiences. Projects of that nature bring excitement and expectation, as we wait to see where they will take us and how greatly they will impact the scholarly ecosystem. Perhaps most important is the need to accomplish this work in an open, collaborative manner, leveraging data standards along the way to enable interoperability and integration with existing architectures.
- Keyword:
- FORCE11, FORCE2016, Contribution Ontology, Attribution, Scholarly Ecosystem
- Subject: MESH:
- Research, Cooperative Behavior, Classification
- Subject: LCSH:
- Ontologies (Information retrieval)
- Creator:
- Gutzman, Karen E, Konkiel, Stacy, White, Marijane, Brush, Matthew Hayden, Ilik, Violeta, Conlon, Mike, Haendel, Melissa A., FORCE11 Attribution Working Group, OpenVIVO Working Group
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Location:
- Portland, Oregon, United States
- Language:
- English
- Date Created:
- 2016
- Rights:
- http://creativecommons.org/licenses/by-nc-nd/3.0/us/
- Resource Type:
- Poster
- Title:
- Research impact and evaluation services in the library: one piece at a time
- Description:
- Lightning talk presented at the Medical Library Association Annual Conference, Toronto, ON. Presented on 05/09/2016.
- Abstract:
- Objective: Over the past year, our library implemented a cohesive set of services around research evaluation and impact assessment, formally structured in the library as the Metrics and Impact Core (MIC). Many of the services utilize the library's expertise in bibliographic data, which can be mined, analyzed and visualized using a variety of techniques to gain a better understanding research impact. Methods: This study discusses the operationalization of these services from the standpoint of a modern medical library and presents the partnerships, resources and tools needed to make this vision a reality. We discuss the types of reports and activities we have developed to suit the needs of our stakeholders using bibliographic data, and the challenges and successes we have found along the way. Results: We found that we often have repeat customers suggesting new projects or requesting updated numbers. Presentations to departments and new faculty, and our close association with our clinical and translational science institute, NUCATS, have created an overall awareness of our services and a synergy that keeps us moving forward. Conclusions: While still in its infancy and often not broadly available, many libraries are committing resources and staff to support research evaluation and impact assessment work on behalf of their institution. Libraries offer the campus a perfect combination of expertise, perspective, and resources to help support and advise their assessment, evaluation and visualization of research impact across the peer-reviewed literature and beyond.
- Keyword:
- research impact, impact, Metrics and Impact Core
- Subject: MESH:
- Bibliometrics, Libraries, Medical
- Subject: LCSH:
- Research--Evaluation
- Creator:
- Gutzman, Karen E, Holmes, Kristi
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2016
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Presentation
- Title:
- Mining for gems: gathering research impact metrics with a DIY approach
- Description:
- Presentation given at the Medical Library Association Annual Conference, Toronto, ON. Presented on 05/15/2016.
- Abstract:
- Objective: Researchers are increasingly curious about the ways in which their scholarly outputs are represented in scholarly, social and mass media platforms. While many databases track citations and other scholarly metrics of impact (though their coverage differs), the options for tracking public consumption is often fragmented, and gaining a clear picture can be difficult. Methods: In this study we compare and contrast the metrics available to researchers, and how librarians can help them utilize specific resources in tracking these metrics. We discuss the complexity of gathering and maintaining these metrics. Additionally, to provide a deeper understanding of these metrics, we describe the processes by which free and subscription-based resources capture data. Lastly, we comment on strengths and common uses of these metrics, and the gaps in coverage. Results: We found the availability and quality of scholarly and alternative metrics varies depending on the resources available. Elsevier's Scopus, Thomson Reuters Web of Science, and Google Scholar are major sources of scholarly metrics, while alternative metrics are available through Altmetric, PlumX, Impactstory, and various scholarly social networking platforms. Each resource has different methods for aggregating data and making it available for librarians and researchers to use. Additionally, each metric has common uses and strengths that should be considered when determining metrics for specific contexts. Conclusions: Scholarly and alternative metrics are increasingly being used as a proxy to measure scientific quality, collaboration, innovation and impact. Librarians can help researchers find these metrics, and understand their common uses, while creating an awareness of how this data is captured, and made available for use. A solid understanding of the strengths, challenges and availability helps librarians and researchers be better consumers and users of these metrics.
- Keyword:
- research impact, impact, Metrics and Impact Core, Medical Library Association
- Subject: MESH:
- Bibliometrics
- Subject: LCSH:
- Scholarly publishing, Research--Evaluation, Bibliographical citations
- Creator:
- Gutzman, Karen E, Shaw, Pamela L, Konkiel, Stacy
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Location:
- Toronto, Ontario, Canada
- Language:
- English
- Date Created:
- 2016
- Rights:
- http://creativecommons.org/licenses/by-nc-nd/3.0/us/
- Resource Type:
- Presentation
- Title:
- Towards semi-automatic monitoring of delivery behavioral interventions
- Abstract:
- Traditional methods for monitoring implementation of evidence-based programs require labor-intensive quality assessments. These assessments generally involve human observation, hence becoming a major bottleneck in the monitoring of implementation. We present the development of computer-based methods for implementation quality measurement. Firstly, we describe 7 principles of automatization necessary tosystematically identify critical dimensions for analysis.Secondly, we present an automatic classifier that uses linguistic patterns to classify sessions between high-fidelity versus low-quality. The classifier was trained on an initial corpus of 22 transcripts which were coded for high and low quality by humans and replicated by machine learning. Our goal is to develop efficient methods that reduce the burden of quality monitoring, and provide timely feedback for delivery supervisors.Overall, we want to explore to what extent quality monitoring can be done with automatic methods [1,3,4].
- Keyword:
- fidelity monitoring, behavioral interventions, automatic fidelity
- Subject: MESH:
- Machine Learning, Evidence-Based Practice, Quality Control, Behavior Therapy
- Subject: LCSH:
- Computational linguistics
- Creator:
- Gallo, Carlos, Berkel, Cady, Sandler, Irwin N., Brown, C Hendricks
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc/3.0/us/
- Resource Type:
- Poster
477. William Henry Holmes
- Title:
- William Henry Holmes
- Description:
- Oil on canvas portrait of Dr. William Henry Holmes by artist John Doctoroff. Photo of framed portrait, measuring 95 cm H x 82 cm W x 10 cm D, housed in Feinberg School of Medicine, Northwestern University, Chicago, IL. Plaque, measuring 10.2 cm H x 15.2 cm W x 2.5 cm D reads: William Henry Holmes, MD Professor of Medicine 1912-1940 Northwestern University Medical School. The portrait was unveiled during a memorial convocation held in the Archibald Church Library, May 27, 1941. (Source: Northwestern University Bulletin, Medical School vol. XLIII, no. 2, Nov. 2, 1942.)
- Keyword:
- art, artwork, Feinberg School of Medicine, Northwestern University, paintings, portraits
- Subject: MESH:
- Schools, Medical--history, Faculty, Medical, Physicians
- Subject: LCSH:
- Medical colleges--Faculty
- Subject: Geographic Name:
- Chicago (Ill.)
- Subject: Name:
- Holmes, William H. (William Henry), 1887-1940
- Creator:
- Doctoroff, John, 1893-1970
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Portraits
- Title:
- New metrics for research evaluation in the age of social media
- Keyword:
- altmetrics, social media
- Subject: MESH:
- Bibliometrics
- Subject: LCSH:
- Research--Evaluation , Scholarly publishing, Bibliographical citations
- Creator:
- Holmes, Kristi, Mohammadi, Ehsan
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Presentation
479. StatTag
- Title:
- StatTag
- Description:
- Related URL refers to the software: https://sites.northwestern.edu/stattag/
- Abstract:
- StatTag is a free plug-in for conducting reproducible research and creating dynamic documents using Microsoft Word with the Stata and SAS statistical software (future versions will work with R). StatTag allows users to embed statistical output (estimates, tables, and figures) within Word and provides an interface to edit statistical code directly from Word. Statistical output can be individually or collectively updated from Word in one-click with a behind-the-scenes call to the statistical program. With StatTag, modification of a dataset or analysis no longer entails transcribing or re-copying results in to a manuscript or table.
- Keyword:
- StatTag, Reproducible Research, Stata, SAS , R, Statistical Code, Plug-in
- Subject: MESH:
- Statistics as Topic
- Subject: LCSH:
- Plug-ins (Computer programs), Statistics--Data processing, R (Computer program language)
- Subject: Name:
- Stata, SAS (Computer file)
- Creator:
- Welty, Leah J, Rasmussen, Luke Vincent, Baldridge, Abigail Shubat, Whitley, Eric
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Date Created:
- 2016-07-01
- Rights:
- https://opensource.org/licenses/MIT
- Resource Type:
- Software or Program Code
- Title:
- Greene Vardiman Black
- Description:
- Bronze bust of Greene Vardiman Black (Dean of Northwestern University Dental School, 1897-1915) by sculptor R. W. Bock. Bust measures 35.56 cm H x 40.64 cm W x 29.21 cm D, base measures: 40.64 cm W x 29.21 cm D. Base includes name. Photo of bust housed in Galter Health Sciences Library, Feinberg School of Medicine, Northwestern University, Chicago, IL. The life-size bust was presented by the Northwestern University Dental School graduating class of 1905 and presented during Commencement Exercises, May 4, 1905. At one time, it was was housed in the Dental Hall of Fame, Ward Building 10th floor, Northwestern University, Chicago campus. (Source: Commencement Exercises Program of Northwestern University Dental School, May 4, 1905; Source: internal inventory, March 6, 1996.)
- Keyword:
- bust, Northwestern University, Northwestern University Dental School, Black, G. V. (Greene Vardiman), 1836-1915, art, artwork, sculpture
- Subject: MESH:
- Schools, Dental--history, Faculty, Dental
- Subject: LCSH:
- Dentists
- Subject: Geographic Name:
- Chicago (Ill.)
- Creator:
- Bock, Richard W., 1865-1949
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Pictorial Works
- Title:
- Science in Society Scientific Images Contest
- Description:
- The same scientific research that generates new understanding and innovation also brings unexpected and often breathtaking beauty. Submitted by Northwestern University researchers, these images represent advances across a wide range of disciplines, including medicine, genetics, chemistry, engineering and nanotechnology. Judged by an interdisciplinary panel of local artists, scientists and community leaders, the winning images have been displayed throughout the Chicagoland area, including Navy Pier, Harold Washington Library, Evanston Public Library, the Noyes Cultural Arts Center, and the Museum of Science and Industry.
- Keyword:
- Scientific images contest, Science in Society
- Subject: MESH:
- Natural Science Disciplines, Research
- Creator:
- In Society, Science
- Publisher:
- Science in Society
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Image, Pictorial Works
- Title:
- 2015 Scientific Images Contest Winners
- Description:
- Scientific research often produces stunning images. The winners of the annual Northwestern Scientific Images Contest, showcase the captivating work being done across a range of Northwestern disciplines, from neurobiology to astrophysics. Free, public exhibitions and events share these images across Chicago each year, organized by Northwestern's research center for science education and community engagement, Science in Society.
- Keyword:
- Scientific images contest
- Subject: MESH:
- Natural Science Disciplines, Research
- Subject: LCSH:
- Science
- Creator:
- Science in Society
- Publisher:
- Science in Society
- Language:
- English
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Image, Pictorial Works
- Title:
- Supporting Potential Life
- Description:
- 2015 First Place, Collaboration is often the key to scientific innovation. Here, a reproductive biologist and a materials scientist and engineer teamed up to help cancer survivors who struggle to conceive children.The image centers on a mouse ovarian follicle (in purple). An ovarian follicle is made up of a developing egg and its surrounding support cells. Normally follicles develop within healthy ovaries, but they can be damaged by harsh cancer therapies. Healthy follicles can be removed before patients undergo treatment, but afterward these saved follicles often struggle to grow into healthy eggs. Laronda and Jakus have created a new paper-like biomaterial made of ovarian proteins (in green). It is designed to support removed follicles as they develop into mature eggs. This image shows a healthy follicle flourishing in the new environment. Someday supportive biomaterials like these could help cancer survivors grow families of their own.Department of Obstetrics & Gynecology + Department of Materials Science & Engineering Tools & Techniques: Scanning Electron Microscope + colored in Photoshop
- Abstract:
- This image originally appeared as part of Northwestern's Scientific Images Contest. The contest and subsequent exhibitions are organized by Science in Society, the university's research center for science education and public engagement. Further information and opportunities to participate are available on their website. Prints and canvas editions of these Northwestern research images can also be purchased online (with the small net profit going to science education and outreach programming in the Chicago area).
- Keyword:
- Cancer, Mouse ovarian follicle, Ovarian proteins, Follicles
- Subject: MESH:
- Ovarian Follicle, Mice
- Creator:
- Laronda, Monica M Marie, Jakus, Adam Edward
- Publisher:
- Science in Society, DigitalHub. Galter Health Sciences Library
- Page Number:
- 1
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Pictorial Works
484. Chaos to Order
- Title:
- Chaos to Order
- Description:
- 2015 Second Place, This image shows two materials sandwiched together. The bottom layer is a rubbery gel; it expands when heated and shrinks when cooled. The top layer is incredibly thin glass.Materials scientists heat the gel to extremely hot temperatures (392 degrees Fahrenheit) and then create a thin layer of glass on the surface. As the gel shrinks it pulls the glass sheet into a wrinkly pattern. The glass ridges ripple in yellow; the darker spots are the valleys in-between.This sandwiching process was invented at Northwestern University to develop new, microscopic instruments and tools. When perfected, this method results in tiny rubber pyramids tipped with fine glass points. The pyramids act like quill pens with built-in shock absorbers -- pens which write with single molecules or nano-particles for ink. Tools like these help nanoparticle researchers with more precise, more delicate maneuvers as they begin to study ever smaller aspects of material design.Department of Materials Science & Engineering Tools & Techniques: Optical Microscope + colored in Photoshop
- Abstract:
- This image originally appeared as part of Northwestern's Scientific Images Contest. The contest and subsequent exhibitions are organized by Science in Society, the university's research center for science education and public engagement. Further information and opportunities to participate are available on their website. Prints and canvas editions of these Northwestern research images can also be purchased online (with the small net profit going to science education and outreach programming in the Chicago area).
- Keyword:
- Materials science, Nanoparticle research
- Subject: MESH:
- Nanoparticles, Nanotechnology
- Creator:
- Hedrick, James Lupton
- Publisher:
- Science in Society, DigitalHub. Galter Health Sciences Library
- Page Number:
- 2
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Pictorial Works
485. Special Snowflake
- Title:
- Special Snowflake
- Description:
- 2015 Third Place, Scientists can press pause on cells in action by rapidly freezing them. The cells must be frozen incredibly quickly --within the blink of an eye. If the freezing process is too slow, the water inside (which makes up most of the cell) forms ice crystals.This microscopic image shows the very early stages of one such snowflake growing. If left to grow each of the six, symmetrical points would continue to branch out, developing into an intricate snowflake visible to the naked eye.In experiments like this one Whittaker and his lab freeze sea urchin cells by plunging them into liquid ethane. When frozen fast enough (and scientists avoid creating snowflakes), researchers can observe cells orchestrating the growth of skeletons. This helps us to understand biomineralization: the process of how bodies grow bones, teeth and other hard biological tissues.Department of Materials Science & EngineeringTools & Techniques: Scanning Electron Microscope + colored in Photoshop
- Abstract:
- This image originally appeared as part of Northwestern's Scientific Images Contest. The contest and subsequent exhibitions are organized by Science in Society, the university's research center for science education and public engagement. Further information and opportunities to participate are available on their website. Prints and canvas editions of these Northwestern research images can also be purchased online (with the small net profit going to science education and outreach programming in the Chicago area).
- Keyword:
- Biomineralization, Sea urchin cells, Liquid ethane
- Subject: MESH:
- Cryopreservation, Cells, Sea Urchins--cytology
- Subject: LCSH:
- Biomineralization
- Creator:
- Whittaker, Michael Lynn
- Publisher:
- Science in Society, DigitalHub. Galter Health Sciences Library
- Page Number:
- 3
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Pictorial Works
486. Aligning the Rainbow
- Title:
- Aligning the Rainbow
- Description:
- 2015 Fourth Place, This wavy image is a field of long, thin nanofibers. These spaghetti-like fibers are thinner than 1/10,000th of a human hair, and just like hair, they can lay in straight lines or get tangled up in nests.Each individual fiber is too small to see, even with a microscope, so the researchers have applied a special computer program to observe how and where the fibers align. Wherever a large clump of fibers lies in the same direction, that area is brightly colored. Wherever it is black, the fibers are all facing different directions.The individual colors assigned depend on the angle of the fibers. Red patches show places where the strands lay horizontally while green and blue areas are vertically aligned. This is easiest to see around the edges of the black circle (a tiny air bubble). The fibers bend around the bubble, lying at each angle along its edge, creating a rainbow.Department of Materials Science & EngineeringTools & Techniques: Fluorescence Microscope + colored in ImageJ
- Abstract:
- This image originally appeared as part of Northwestern's Scientific Images Contest. The contest and subsequent exhibitions are organized by Science in Society, the university's research center for science education and public engagement. Further information and opportunities to participate are available on their website. Prints and canvas editions of these Northwestern research images can also be purchased online (with the small net profit going to science education and outreach programming in the Chicago area).
- Keyword:
- Nanofibers
- Subject: MESH:
- Nanofibers
- Creator:
- Boekhoven, Job
- Publisher:
- Science in Society, DigitalHub. Galter Health Sciences Library
- Page Number:
- 4
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Pictorial Works
- Title:
- Mushroom Cloud in a Bubble Chamber
- Description:
- 2015 Fifth Place, This chamber resides in a water tank buried 400 feet underground at Fermilab. It is surrounded by high-speed cameras, pressure and acoustic sensors, and temperature controls.The liquid chemical is superheated: any tiny disturbance will cause it to bubble. In this image a single neutron collided with the target fluid creating a bubble which then rose the surface, causing this small, atom-bomb-like eruption. The high-speed cameras were triggered immediately resulting in this photo, and the pressure was increased to quench the bubble explosion.This particular test helped scientists calibrate and test the sensitivity of the chamber. This 8-inch jar is one of several, some are as small as test tubes, others span a meter in diameter. Based on their observations, the research team plan to build a larger chamber which is even more sensitive and stable. This will hopefully help scientists directly detect dark matter.PICO Dark Matter Research CollaborationTools & Techniques: High-speed Camera
- Abstract:
- This image originally appeared as part of Northwestern's Scientific Images Contest. The contest and subsequent exhibitions are organized by Science in Society, the university's research center for science education and public engagement. Further information and opportunities to participate are available on their website. Prints and canvas editions of these Northwestern research images can also be purchased online (with the small net profit going to science education and outreach programming in the Chicago area).
- Keyword:
- Dark matter, Bubble chamber
- Subject: MESH:
- Neutrons
- Subject: LCSH:
- Bubble chambers, Neutrons, Dark matter (Astronomy)
- Creator:
- Jin, Miaotianzi
- Publisher:
- Science in Society, DigitalHub. Galter Health Sciences Library
- Page Number:
- 5
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Pictorial Works
488. William E. Morgan
- Title:
- William E. Morgan
- Description:
- Oil on canvas portrait of Dr. William E. Morgan by Anna Lynch. Measures 102 cm H x 88 cm W x 6 cm D. B/W photo of framed colored portrait housed in Galter Health Sciences Library, Feinberg School of Medicine, Northwestern University, Chicago, IL. Plaque, measuring 10.2 cm H x 15.2 cm W x 2.5 cm D reads: William E. Morgan, M.D. Professor of Surgery, 1881 to 1920 Northwestern University Medical School. On October 2, 1934, Dr. Morgan was honored by the medical school on Founders Day when his portrait was hung in the Archibald Church Library. (Sources: 1934 Founders Day program and 2012 internal inventory)
- Keyword:
- Feinberg School of Medicine, art
- Subject: MESH:
- Schools, Medical--history, Faculty, Medical
- Subject: LCSH:
- Medical colleges--Faculty
- Subject: Geographic Name:
- Chicago (Ill.)
- Subject: Name:
- Morgan, William E., 1858-
- Creator:
- Lynch, Anna, 1865-1946
- Publisher:
- DigitalHub. Galter Health Sciences Library
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc/3.0/us/
- Resource Type:
- Portraits
489. When Worlds Collide
- Title:
- When Worlds Collide
- Description:
- Honorable Mention, We have discovered thousands of planets outside our own Solar System. Some of these exoplanet systems are much more tightly packed than ours. In such a system, what would happen if two planets the size of Jupiter collided?This team designed highly-specialized computer programs to model what might happen. This image shows the simulated planetary system shortly after collision. The two circles represent the planets original orbits. (They crashed where the orbits were very close together on the right-hand side.) The spiraling cloud is plan-etary matter sprayed out across the system. The bright object near the bottom of the image could be a new planet forming from the remains--notice how it no longer follows either of the original orbits.Some currently observed exoplanets may have undergone such a collision (or collisions) many years ago. Cutting-edge simulations like these help us understand how planets form and how they can change over time. Center for Interdisciplinary Exploration & Research in Astrophysics (CIERA)Tools & Techniques: Computer simulation laid over a NASA Kepler telescope image
- Abstract:
- This image originally appeared as part of Northwestern's Scientific Images Contest. The contest and subsequent exhibitions are organized by Science in Society, the university's research center for science education and public engagement. Further information and opportunities to participate are available on their website. Prints and canvas editions of these Northwestern research images can also be purchased online (with the small net profit going to science education and outreach programming in the Chicago area).
- Keyword:
- Exoplanets, Simulated planetary system, Collision
- Subject: MESH:
- Computer Simulation, Planets
- Subject: LCSH:
- Computer simulation, Extrasolar planets, Planetary theory
- Creator:
- Geller, Aaron M, Hwang, Jason ahern, Rasio, Frederic A
- Publisher:
- Science in Society, DigitalHub. Galter Health Sciences Library
- Page Number:
- 6
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Pictorial Works
490. Vision in Bloom
- Title:
- Vision in Bloom
- Description:
- Honorable Mention, This image shows a mouse retina. A retina contains millions of neurons which detect light and transmit signals to our brain. The small white dots shown here are one type of neuron which receive light information from the outside world.The lines heading toward the center are called axons. Axons act like telephone wires, sending light information from these neurons out of the eye, along the optic nerve, and on to the brain. This process of transmitting information from the sensitive neurons in our eyes to our brain is the basis of how we see.Researcher Jasmine Lucas and other scientists study neurons in the retina to understand how different cells within the eye develop and mature.Department of NeurobiologyTools & Techniques: Epifluorescent Microscope
- Abstract:
- This image originally appeared as part of Northwestern's Scientific Images Contest. The contest and subsequent exhibitions are organized by Science in Society, the university's research center for science education and public engagement. Further information and opportunities to participate are available on their website. Prints and canvas editions of these Northwestern research images can also be purchased online (with the small net profit going to science education and outreach programming in the Chicago area).
- Keyword:
- Mouse retina, Neurons, Axons
- Subject: MESH:
- Retina, Mice, Neurons, Axons
- Creator:
- Lucas, Jasmine Ashley
- Publisher:
- Science in Society, DigitalHub. Galter Health Sciences Library
- Page Number:
- 7
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Pictorial Works
- Title:
- Practice Makes Perfect
- Description:
- Honorable Mention, Scientific discovery is usually a long process of trial and error. Researcher Christine Laramy has been testing her new method for measuring nanoparticles for several months.Laramy drops a soapy solution containing microscopic amounts of gold into a small tube and then spins it very fast. As the solution spins, the suspended gold clumps together and these heavier clusters fall to the bottom. The soapy liquid is then skimmed off and the gold nanoparticles are left to dry.In this image the gold nanoparticles formed into spheres and cubes, but the soapy solution wasnt completely removed. (You can see it here in purple.) This soapy residue hinders Laramys measurements: the computer program she invented requires a plain background to accurately calculate the amount of gold.After this image was taken Laramy experimented for several more weeks to perfect the separation process, and today her innovative measurement software is being trialed in labs and universities across the country.Department of Materials Science & Engineering Tools & Techniques: Transmission Electron Microscope + colored in Photoshop
- Abstract:
- This image originally appeared as part of Northwestern's Scientific Images Contest. The contest and subsequent exhibitions are organized by Science in Society, the university's research center for science education and public engagement. Further information and opportunities to participate are available on their website. Prints and canvas editions of these Northwestern research images can also be purchased online (with the small net profit going to science education and outreach programming in the Chicago area).
- Keyword:
- Nanoparticles
- Subject: MESH:
- Nanoparticles, Gold, Software Design
- Creator:
- Laramy, Christine Rose
- Publisher:
- Science in Society, DigitalHub. Galter Health Sciences Library
- Page Number:
- 8
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Pictorial Works
492. Magnetic Honeycomb
- Title:
- Magnetic Honeycomb
- Description:
- Honorable Mention, The microscopic particles shown here are made of iron oxide, or rust, just like on a car. But these nanoparticles are tiny, 100,000 times thinner than a sheet of paper.In this image all the nanoparticles are the same size and shape and distance apart, and each magnetic particle is subjected to the attraction and repulsion forces of its neighbors. As a result, the magnetic nano-particles self-assemble (or come together) in a closely-packed honeycomb pattern. Iron oxide nanoparticles like these are already used to help people suffering from anemia, or iron deficiency. Researchers study how these magnetic nanoparticles interact with each other and with tissues in the body, which can open new avenues for nontoxic, targeted tests and treatments for cancer, Alzheimers and cardiovascular disease.Northwestern University Atomic & Nanoscale Characterization Experimental Center (NUANCE)Tools & Techniques: Transmission Electron Microscope + colored in Photoshop
- Abstract:
- This image originally appeared as part of Northwestern's Scientific Images Contest. The contest and subsequent exhibitions are organized by Science in Society, the university's research center for science education and public engagement. Further information and opportunities to participate are available on their website. Prints and canvas editions of these Northwestern research images can also be purchased online (with the small net profit going to science education and outreach programming in the Chicago area).
- Keyword:
- Magnetic nanoparticles, Iron oxide nanoparticles, Anemia, Iron deficiency, Cancer, Alzheimers disease, Cardiovascular disease
- Subject: MESH:
- Magnetite Nanoparticles
- Creator:
- Nandwana, Vikas
- Publisher:
- Science in Society, DigitalHub. Galter Health Sciences Library
- Page Number:
- 9
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Pictorial Works
- Title:
- From Salt Flowers Grew
- Description:
- Honorable Mention, Salt crystals like these grow from colorless, empty-looking solutions. Inside each solution chemicals are dissolved in water. When the water evaporates these striking chemical patterns are left behind.Depending on the type of salt and the way the liquid evaporates, beautiful crystals like these flowery patterns can form. The shape of each flower gives valuable information about the internal structure of the crystals and how they formed.In this experiment researchers wanted to observe how nanoparticles assemble into microscopic crystals. These crystals are built from molecules which researchers use to make and assemble nanoparticles. The better we understand nano-scale building blocks and how they work, the more effectively we can use them to design new materials, make smaller devices, and more specifically target diseases.Department of Materials Science & Engineering Tools & Techniques: Scanning Electron Microscope + colored in Photoshop
- Abstract:
- This image originally appeared as part of Northwestern's Scientific Images Contest. The contest and subsequent exhibitions are organized by Science in Society, the university's research center for science education and public engagement. Further information and opportunities to participate are available on their website. Prints and canvas editions of these Northwestern research images can also be purchased online (with the small net profit going to science education and outreach programming in the Chicago area).
- Keyword:
- Nanoparticles, Microscopic crystals
- Subject: MESH:
- Nanoparticles, Salts
- Creator:
- O'Brien, Matthew Nathan
- Publisher:
- Science in Society, DigitalHub. Galter Health Sciences Library
- Page Number:
- 10
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Pictorial Works
494. Carbon on Fire
- Title:
- Carbon on Fire
- Description:
- Honorable mention, In this image a thin layer of carbon atoms forms a lattice. (You can see the blue-green bumps interlocked in a tidy hexagonal pattern.) The center of this lattice is disrupted by the presence of a crystal defect; this influences the electrons of the central carbon atoms and alters the hexagonal configuration. Like a pebble dropped in a still pond, a small change in the middle ripples out, distorting the pattern all around it.This image is more like a contour or elevation map than a photograph. It was made with a Scanning Tunneling Microscope (STM). Instead of using lenses like a camera, an STM uses a very fine needle to trace just above the surface of microscopic structures. Here, the surface height is color-coded: the white bumps are the tallest areas and the black depressions are lowest.Department of Materials Science & EngineeringTools & Techniques: Scanning Tunneling Microscope + colored in Photoshop
- Abstract:
- This image originally appeared as part of Northwestern's Scientific Images Contest. The contest and subsequent exhibitions are organized by Science in Society, the university's research center for science education and public engagement. Further information and opportunities to participate are available on their website. Prints and canvas editions of these Northwestern research images can also be purchased online (with the small net profit going to science education and outreach programming in the Chicago area).
- Keyword:
- Carbon
- Subject: MESH:
- Carbon, Microscopy, Scanning Tunneling
- Creator:
- Liu, Xiaolong
- Publisher:
- Science in Society, DigitalHub. Galter Health Sciences Library
- Page Number:
- 11
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Pictorial Works
495. Nano Daisy Blossom
- Title:
- Nano Daisy Blossom
- Description:
- Honorable Mention, Results are far from guaranteed in nanotechnology research. Trying to create and manipulate materials on such a tiny scale these puffs are less than 1/40th the width of a single human hair -- is cutting-edge science, and unexpected things happen all the time.In this experiment Chen and Crosby were attempting to create nanoparticle cubes. Manipulating this material, strontium titanate, could help pave the way for faster smart phones and other electronic devices.Instead of cubes, however, Chen and Crosbys recipe yielded these flower-like clusters. Nanoparticle synthesis can sometimes seem like black magic explains Chen, but the team isnt deterred. We learn from these accidents she adds, eight out of ten times it doesnt work, but we have to persevere to learn.Department of Materials Science & EngineeringTools & Techniques: Transmission Electron Microscope + colored in WSxM
- Abstract:
- This image originally appeared as part of Northwestern's Scientific Images Contest. The contest and subsequent exhibitions are organized by Science in Society, the university's research center for science education and public engagement. Further information and opportunities to participate are available on their website. Prints and canvas editions of these Northwestern research images can also be purchased online (with the small net profit going to science education and outreach programming in the Chicago area).
- Keyword:
- Nanoparticles, Strontium titanate
- Subject: MESH:
- Nanoparticles
- Subject: LCSH:
- Strontium titanate
- Creator:
- Chen, Bor-Rong, Crosby, Lawrence Anthony
- Publisher:
- Science in Society, DigitalHub. Galter Health Sciences Library
- Page Number:
- 12
- Date Created:
- 2015
- Rights:
- All rights reserved
- Resource Type:
- Pictorial Works
- Title:
- Pediatric Neurology Briefs: Volume 26, Issue 06
- Description:
- Pediatric Neurology Briefs is an Open Access (OA) continuing education service designed to expedite and facilitate the review of current scientific research and advances in child neurology and related subjects. The editors provide detailed monthly summaries of published articles, followed by commentaries based on their experience and corroborated by appropriate supplementary citations. Pediatric Neurology Briefs provides pediatric neurologists, neurologists, neurosurgeons, pediatricians, psychiatrists, psychologists, educators and other health professionals with a detailed reference guide to the diagnosis, etiology, pathology, treatment and prognosis of nervous diseases of infants, children and adolescents. Content is intended to be accessible to readers in any medical discipline.
- Keyword:
- Pediatrics, Neurology
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Original Identifier:
- nlm-ta: Pediatr Neurol Briefs, pmc: pedneurbriefs, iso-abbrev: Pediatr Neurol Briefs, e-ISSN: 2166-6482, p-ISSN: 1043-3155
- Title:
- Pediatric Neurology Briefs: Volume 26, Issue 08
- Description:
- Pediatric Neurology Briefs is an Open Access (OA) continuing education service designed to expedite and facilitate the review of current scientific research and advances in child neurology and related subjects. The editors provide detailed monthly summaries of published articles, followed by commentaries based on their experience and corroborated by appropriate supplementary citations. Pediatric Neurology Briefs provides pediatric neurologists, neurologists, neurosurgeons, pediatricians, psychiatrists, psychologists, educators and other health professionals with a detailed reference guide to the diagnosis, etiology, pathology, treatment and prognosis of nervous diseases of infants, children and adolescents. Content is intended to be accessible to readers in any medical discipline.
- Keyword:
- Pediatrics, Neurology
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Original Identifier:
- nlm-ta: Pediatr Neurol Briefs, pmc: pedneurbriefs, iso-abbrev: Pediatr Neurol Briefs, e-ISSN: 2166-6482, p-ISSN: 1043-3155
- Title:
- Pediatric Neurology Briefs: Volume 26, Issue 09
- Description:
- Pediatric Neurology Briefs is an Open Access (OA) continuing education service designed to expedite and facilitate the review of current scientific research and advances in child neurology and related subjects. The editors provide detailed monthly summaries of published articles, followed by commentaries based on their experience and corroborated by appropriate supplementary citations. Pediatric Neurology Briefs provides pediatric neurologists, neurologists, neurosurgeons, pediatricians, psychiatrists, psychologists, educators and other health professionals with a detailed reference guide to the diagnosis, etiology, pathology, treatment and prognosis of nervous diseases of infants, children and adolescents. Content is intended to be accessible to readers in any medical discipline.
- Keyword:
- Pediatrics, Neurology
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Original Identifier:
- nlm-ta: Pediatr Neurol Briefs, pmc: pedneurbriefs, iso-abbrev: Pediatr Neurol Briefs, e-ISSN: 2166-6482, p-ISSN: 1043-3155
- Title:
- Pediatric Neurology Briefs: Volume 26
- Description:
- Pediatric Neurology Briefs is an Open Access (OA) continuing education service designed to expedite and facilitate the review of current scientific research and advances in child neurology and related subjects. The editors provide detailed monthly summaries of published articles, followed by commentaries based on their experience and corroborated by appropriate supplementary citations. Pediatric Neurology Briefs provides pediatric neurologists, neurologists, neurosurgeons, pediatricians, psychiatrists, psychologists, educators and other health professionals with a detailed reference guide to the diagnosis, etiology, pathology, treatment and prognosis of nervous diseases of infants, children and adolescents. Content is intended to be accessible to readers in any medical discipline.
- Keyword:
- Pediatrics, Neurology
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Date Created:
- 2012
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Original Identifier:
- nlm-ta: Pediatr Neurol Briefs, pmc: pedneurbriefs, iso-abbrev: Pediatr Neurol Briefs, e-ISSN: 2166-6482, p-ISSN: 1043-3155
- Title:
- Pediatric Neurology Briefs: Volume 27, Issue 10
- Description:
- Pediatric Neurology Briefs is an Open Access (OA) continuing education service designed to expedite and facilitate the review of current scientific research and advances in child neurology and related subjects. The editors provide detailed monthly summaries of published articles, followed by commentaries based on their experience and corroborated by appropriate supplementary citations. Pediatric Neurology Briefs provides pediatric neurologists, neurologists, neurosurgeons, pediatricians, psychiatrists, psychologists, educators and other health professionals with a detailed reference guide to the diagnosis, etiology, pathology, treatment and prognosis of nervous diseases of infants, children and adolescents. Content is intended to be accessible to readers in any medical discipline.
- Keyword:
- Pediatrics, Neurology
- Publisher:
- DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Original Identifier:
- nlm-ta: Pediatr Neurol Briefs, pmc: pedneurbriefs, iso-abbrev: Pediatr Neurol Briefs, e-ISSN: 2166-6482, p-ISSN: 1043-3155