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- Title:
- Racial and Ethnic Disparities in Illinois Lung Cancer Incidence, Mortality Stage at Diagnosis, Surgical Treatment, and Screening
- Abstract:
- Objectives To determine the extent of lung cancer racial and ethnic disparities in Illinois.Methods We used census data to compute race and ethnic rate ratios for publicly available Illinois lung cancer registry and hospital admissions data comparing incidence, mortality, stage at diagnosis, medical admissions, surgical admissions, screening and smoking prevalence by race and ethnicity.Results Despite having a lower prevalence of smoking compared to non-Hispanic whites, non-Hispanic blacks had the highest lung cancer incidence, mortality, diagnosis at distant stage, and lung cancer related hospital admission rates, as well as a lower screening rate and fewer surgical admissions. Hispanics had lower rates of lung cancer incidence and hospital care but had a much higher rate of diagnosis at distant stage.Conclusions Non-Hispanic blacks in Illinois continue to have a disproportionate burden of lung cancer morbidity and mortality. Disparities in lung cancer outcomes appear to be driven by social determinants of health rather than smoking rates.
- Keyword:
- lung cancer, health disparities , Illinois , race , ethnicity
- Subject: MESH:
- Ethnic and Racial Minorities, Lung Neoplasms
- Subject: Geographic Name:
- Illinois
- Creator:
- Golechha, Ritika
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-05-28
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
- Title:
- Critical Care Challenges in the Global South: An Ethnographic Perspective from Argentina
- Abstract:
- Objective: Provide a qualitative study of the experiences and challenges of intensivists providing care in public ICUs in a Middle-Income country like Argentina.Methods: Research was conducted during 15 months in two Intensive Care Units in two public hospitals in the periphery of Buenos Aires, Argentina. The data was collected through deep-immersion participant observation, semi-structured interviewing, literature review, and elicitation of professional diaries from physicians.Results: Intensivists in the study report experiencing various challenges in their profession, including: stressful clinical scenarios; difficult management of the relationship with patient family members, engaging in bioethical and end-of-life discussions and decisions; infrastructural constraints such as lack of resources, budget cuts and austerity measures, low wages, and broader economic uncertainty.Discussion: The importance of socio-cultural and political economic-context is often placed as a background in many studies that examine the ICU as a working environment. Qualitative and ethnography studies can shed light on how specific conditions affect the work of critical care professionals, thus adding nuance and depth to quantitative or survey studies on workplace satisfaction. During the COVID-19 pandemic, ICUs have been put under extreme strain all over the world, albeit differently. Qualitative perspectives are and will be especially important calls for more qualitative studies that examine both the importance of context and the experiences of intensive care professionals at this trying time.
- Keyword:
- Argentina , critical care, public hospitals
- Subject: MESH:
- Intensive Care Units, Critical Care
- Subject: Geographic Name:
- Argentina
- Creator:
- Garofalo, Livia Lucia
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-01-09
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
- Title:
- An Analysis of Comprehensive Sex Education in the US
- Abstract:
- Objective:To provide in-depth analysis of Comprehensives Sex Education (CSE) in the US. Methods: To understand the context of CSE, by comparing and contrasting evidence for CSE and abstinence-only until marriage (AOUM) curriculums, laws concerning sex education, and three different CSE delivery methods. Internship with Anne and Robert H. Luries Sexuality Education Program gave an insight into local CSE implementation. The program provides CSE sessions for schools. At the end of every session, students complete a survey and write a question on a sticky note. Quantitative and qualitative analysis of this data was conducted. Results: Both sex education curriculums were implemented with the hope of reducing unintended adolescent pregnancies and decrease high rates of STI and HIV/AIDS among youths. CSE is the only program that has been successful in reducing these factors. It is also inclusive of sexual minorities. Funding for sex education flows from federal grants and guidelines; states allocate the money to schools and local organizations. There are three types of CSE delivery methods include peer to peer, utilizing technology, and health educator run programs. Luries program is an example of a health educator run program. Survey data were available for three schools, and sticky notes for five schools. Quantitative analysis of the five items on the survey found statistical significance for Kruskal-Wallis and Fischers exact test for question three, I am able to communicate my differences to another person. Qualitative analysis was conducted by grouping comments by the National Sexuality Education Standards (NSES) seven topics of pregnancy and reproduction, healthy relationships, STI &HIV, anatomy & physiology, personal safety, puberty, and identity. Discussion: CSE is effective because it emphasizes abstinence but also provides medically, accurate information about contraception. It has been shown that CSE increases rates of safe sex practices but has no impact on the sexual debut of adolescents. The curriculum is inclusive of sexual minorities ignored in the AOUM model. Its primary aim is not to dissuade youth from sex, but to create a foundation. CSE is a progressive curriculum that teaches age-appropriate information about the physical, biological, and emotional aspects of the seven NSES topics. Through qualitative analysis, students were affirmed of their identity thank you for helping me feel safe for being bisexual. Youth learned skills on how to approach situations concerning personal safety. This is seen in the comment, I liked how we dont always have to say yes without being rude. Students discovered the diverse manifestations of puberty and felt that they were more knowledgeable about my body. The analysis illustrated how students wanted to learn the different aspects of health. Quantitatively, there was one question with statistical significance, which represents a need to teach skills to help adolescents communicate their differences to another. On the ground, the perspective of a CSE program illustrated the importance of teaching more than just abstinence and puberty. By having an inclusive curriculum of sexual minorities, it affirms a vulnerable population that is more likely to experience bullying and depression. It increases safe sex practices, which contributes to a reduction of STI rates. Adolescents disproportionately experience high rates of STIs in the US. By teaching personal safety and healthy relationships, the curriculum builds a foundation that can decrease interpersonal violence, which is high among students. CSE implementation is a vital method of primary prevention of many of the issues that face adolescents today.
- Keyword:
- comprehensive sex education , sex , USA
- Subject: MESH:
- Sex Education
- Subject: Geographic Name:
- United States
- Creator:
- Gadiraju, Meghana
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2019-10-21
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
- Title:
- France and Germany as U.S. Role Models for Lowering Health Expenditures
- Abstract:
- OBJECTIVE: To examine the historical development of the German and French health care systems and how their financing and expenditures might inform policy reform for the U.S. METHODS: Available OECD data on health status, health expenditures, and medical supply factors in France and Germany are presented as comparisons to the U.S. Structural characteristics of each countries systems were explored based on a literature review of historical context and financing of their healthcare systems. Indicators of health expenditures such as hospital utilization, physician remuneration and pharmaceutical costs were compared to the U.S. RESULTS: The German sickness funds model of insurance differs from the French reliance on national health insurance. The U.S. spends a much greater percentage of GDP, has much higher health expenditures per capita than its counterparts, and a lower proportion of U.S. residents have health insurance than France and Germany. The main drivers of health expenditures in the U.S. include administrative costs of operating the multi-payer system, lack of price regulation, privatized costs in medical education, and higher physician salaries and pharmaceutical costs. DISCUSSION: The experience of national health insurance systems in Germany and France shows that expanding risk pools for health insurance can simplify systems, provide coordinated care, decrease health expenditures, and prohibit incentives to market to the most affluent privately insured patients. To emulate the successful French and German systems there would need to be a major restructuring of the U.S. healthcare system perhaps creating not-for-profit, private entities within an existing public program, a model similar to the German sickness funds.
- Keyword:
- USA, France, Germany, health care, health insurance
- Subject: MESH:
- Insurance, Health, Health Expenditures, National Health Programs, Cross-Cultural Comparison
- Subject: Geographic Name:
- France, Germany, United States
- Creator:
- Fu, Michelle
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-05-13
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
- Title:
- Community-Engaged Literary Pen Pal Program
- Abstract:
- Background - This community-engaged research project, titled Bridge Through Books, paired Chicago Public School (CPS) and District 64 suburban third grade students in a literary pen pal program. Bridge Through Books aimed to improve reading and writing frequency and enjoyment. The program also sought to develop social connections among the urban and suburban youth. The researcher hypothesized that students would cite increased frequency and enjoyment of reading and writing after the intervention compared to the control group. Furthermore, the researcher hypothesized that social connectedness and discussions about books with students from other schools would be higher among those participating in the program. Methods - Eight schools were selected to participate, four in CPS and four in District 64. School librarians delivered the interventions. The intention was for each student to write three letters to their literary pen pal or pen pals. Each school had an intervention group that participated in the program and a control group that did not participate in the program. Surveys were completed by control and experimental classrooms prior to and after the intervention. These surveys were then assessed to determine if the program objectives were accomplished. The intervention was delivered from January through March, 2020.Results - Two out of eight schools completed the pre-intervention and post-intervention survey data. Pre-intervention data was retrieved from seven experimental classrooms and six out of eight control classrooms among participating schools. Pre-intervention survey responses were similar across the control and experimental groups. Among the two schools that completed pre-intervention and post-intervention data, a statistically significant higher number of students perceived they developed friendships with students from their partner school after completing the intervention (p=<0.001). Additionally, a statistically significant higher number of students in the experimental group stated that after the intervention, they spoke to friends at other schools about books (p=<0.001). There was no statistical improvement in reading and writing frequency and enjoyment. Fishers exact tests were used to compare the equality of survey response proportions. Discussion - Due to the small sample size of control group and experimental group students that completed both surveys, it is difficult to say whether or not the program achieved its objectives. However, the groups that participated in the program felt friendships were developed and that books were talked about more with students who went to other schools. Because of project implementation difficulties, inconsistent communication between the lead researcher and participating librarians, and outside factors such as the CPS 2019 strike and the 2020 COVID-19 pandemic, not all schools completed the intervention. Bridge Through Books, a novel literary pen pal program, was implemented in the Chicagoland area in an effort to promote reading, writing, and social connectedness among urban and suburban third grade youth. The program was not successful in achieving all of these goals and should be altered if the program were to be implemented again to address these unaccomplished goals and to address the potential burden the program placed on participating librarians.
- Keyword:
- reading, writing, pen pal, elementary school
- Subject: MESH:
- Literacy, Social Networking, Child
- Subject: LCSH:
- Pen pals
- Creator:
- Ellyin, Alexander
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-05-15
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
- Title:
- The Role of Activism in Combating Feelings of Helplessness Among Chicago Adolescents: A Qualitative Analysis
- Abstract:
- Background: Racism is a public health issue that has both immediate effects and also long term, generational consequences. Racisms impacts spans from increased incidences of chronic physical health and mental health conditions to lost job opportunities and affordable housing. Racism is pervasive and has persistent effects on a significant portion of the US population. Previous research has explored the effects of direct racism on adults health outcomes, but there is limited data on the impacts of vicarious racism on adolescents and their emotional health. Moreover, there is even more limited data on successful strategies to help minorities combat the negative effects of racism in their lives. Objective: This study seeks to examine how adolescents interact with social media and racially-charged stories online. We then explore the emotional responses and strategies adolescents utilize to combat those emotions. Methods: We conducted four (N=4) focus groups with adolescents aged 13-19, with a total of 18 participants. The research team conducted semi-structured focus groups. Focus groups were recorded, transcribed, coded, and analyzed. Results: This paper focused on three main themes that emerged from the data: helplessness, resilience/support systems, and activism as a coping strategy. Adolescents mentioned feelings of helplessness as an initial reaction to racist events and a sense of lack of control. On the other hand, they were able to identify people in their lives who they lean on for support and how activism can sometimes combat those feelings and help them feel like they are making a difference. Discussion: Adolescents are astutely aware of racial conflicts. Not only are they able to properly identify the conflicts, but they have the nuanced view of how racial tensions affect them and people around them. The insights gained from this focus group may allow stakeholders to consider anti-racism strategies that include addressing adolescents emotional needs, including the lack of control, and developing coping strategies on familiar platforms, like social media.
- Keyword:
- activism , Chicago, emotional health, racism
- Subject: MESH:
- Racism, Public Health, Political Activism, Adolescent
- Subject: Geographic Name:
- Illinois--Chicago
- Creator:
- Ekwueme, Patricia Oby
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-04-17
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
- Title:
- Emerging US Socioeconomic and Health Disparities in the COVID-19 Pandemic: A Scoping Review
- Abstract:
- The coronavirus disease 2019 (COVID-19) emerged as a pandemic in late March 2020, with cases escalating in the US. Health disparities, caused by underlying low socioeconomic factors, are heightened in the current COVID-19 pandemic and response. These health disparities are especially evident for disenfranchised populations like low-income, Black and Hispanic, and incarcerated communities. This scoping review was conducted to provide an overview of the evidence that highlights the need for public health policies sensitive to socioeconomic and health disparities in the US. First, the review provides evidence suggesting that low-income earners, Blacks and Hispanics, and incarcerated populations are among those with the greatest risk for COVID-19 due to underlying disparities. Second, it contains a review of the research that suggests these populations also have a decreased ability to adhere to social-distancing directives. The results suggest that there is an increased burden and exposure to COVID-19 among the poor, Blacks and Hispanics and incarcerated, and that these populations are less able to follow social-distancing guidelines. Overall, new policies should challenge existing socioeconomic and health disparities by addressing economic security, housing security, criminal justice, and healthcare access. Therefore, the current COVID-19 pandemic response needs to be part of a larger effort to combat health and socioeconomic inequity in the US.
- Keyword:
- COVID-19, health disparities , public health policy
- Subject: MESH:
- Socioeconomic Factors, Health Disparate, Minority and Vulnerable Populations, COVID-19, Health Policy
- Subject: Geographic Name:
- United States
- Creator:
- Ekeh, Odera
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-05-10
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
- Title:
- Food security mediates the decrease in depressive symptoms among smallholder women farmers in a participatory nutrition-sensitive agroecology intervention in rural Tanzania
- Abstract:
- Objective: To investigate if food security mediated the impact of a nutrition-sensitive agroecology intervention on womens depressive symptoms. Design: We used annual longitudinal data (4 time points) from a cluster-randomized effectiveness trial of a nutrition-sensitive agroecology intervention, the Singida Nutrition and Agroecology Project. Structural equation modeling estimation of total, natural direct, and natural indirect effects was used to investigate food securitys role in the interventions impact on womens probable depression (CES-D > 17) over three years. Setting: Rural Singida, Tanzania. Participants: 548 food insecure, married, smallholder women farmers with children < 1-year-old at baseline. Results: At baseline, one third of the women in each group had probable depression (Control: 32.0%, Intervention: 31.9%, p-difference=0.97). The intervention lowered odds of probable depression by 43% (OR=0.57, 95% CI: 0.43-0.70). The effect of the intervention on probable depression that was due to differences in food security was approximately 10% (OR = 0.90, 95% CI: 0.83-0.95). Conclusions: Nutrition-sensitive agricultural interventions can have broader impacts than previously demonstrated, i.e., on mental health, and food security plays an important causal role in this pathway. These data suggest nutrition-sensitive agriculture interventions have the potential to reduce the loss of quality life years for women in farming communities. Future agricultural and nutrition projects should include mental health evaluations to determine generalizability.
- Keyword:
- depression, agroecology , Tanzania
- Subject: MESH:
- Depressive Disorder, Rural Population, Farmers, Food Security
- Subject: Geographic Name:
- Tanzania
- Creator:
- Cetrone, Hollyn M.
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-05-26
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
- Title:
- Congenital Syphilis in Chicago: An Analysis of Recent Cases
- Abstract:
- Objective: Congenital syphilis (CS) occurs during pregnancy when maternal infection is not adequately treated in a timely manner. It can result in miscarriage, stillbirth, and multiple complications in the newborn including death. Since congenital syphilis is preventable, each case represents a public health missed opportunity. The incidence of congenital syphilis in the United States has been rising yearly since 2012. The purpose of this study is to analyze all congenital syphilis cases in Chicago from 2015 to 2019 using multiple data sources in order to determine in each case why the disease was not averted. This must be done in order to target resources appropriately and impact future cases. Methods: All probable congenital syphilis cases reported to the Chicago Department of Public Health (CDPH) from January 1, 2015 through December 31, 2019 were reviewed. Both quantitative and qualitative data were collected from multiple sources. Missed opportunities for preventing CS were determined for each case and classified as either patient, provider, or system factors. Data on causes were collected, summarized, and divided by year to look for trends over time. Results: There were 65 CS cases in the five years, with a majority occurring in non-Hispanic Black women in their 20s from communities with high levels of economic hardship. There was a steady decline in cases over time, from 24 in 2015 to 8 in 2019. Of these cases, 41 (63.1%) were attributed to patient factors, the most common being a lack of prenatal care in 27 (41.5% of all cases). Provider factors were responsible 17 (26.1%) of cases, including both testing and treatment errors. Systems factors were responsible for 7 (10.8%). Numbers were too small to make statements about changes in type of factor over time. Discussion: The incidence of CS cases in Chicago has decreased over the past 5 years, but there are marked disparities by both race and community. Lack of prenatal care is the single most common cause of CS, but provider errors and systems factors are responsible for a significant portion as well. In order to impact this disease, resources need to be focused on engaging at-risk communities in prenatal care as well as increasing education to providers and streamlining referral systems when necessary to effect treatment. A multi-level approach is necessary to eliminate CS in Chicago.
- Keyword:
- congenital syphilis , Chicago, public health
- Subject: MESH:
- Syphilis, Congenital
- Subject: Geographic Name:
- Illinois--Chicago
- Creator:
- Cejtin, Helen Elizabeth
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-06-05
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
- Title:
- Charity Care Disparities in Illinois Hospitals: A Policy Review
- Abstract:
- Illinois Cook County Health system has, since the mid 1800s, prided itself in the care it provides for Chicagolands underserved. However, for several decades the County system and Cook County taxpayers have borne the brunt of assisting these populations, especially in regards to supplying charity care, or free medical care that doctors provide to patients who are uninsured. A large gap exists in the charity care being contributed by Cook County Health and all other Chicago area hospitals which, as non-profit institutions, receive tens of millions in foregone property and sales taxes. This paper seeks to explore why that disparity exists, as well as what the Illinois health care system could do to better allocate resources for indigent populations.
- Keyword:
- charity care, Cook County, health inequity, health disparities
- Subject: MESH:
- Charities, Health Inequities, Hospitals
- Subject: Geographic Name:
- Illinois
- Creator:
- Bundra, Sarah
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-05-08
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
211. Changes in Adolescent Binge Drinking between 2007 to 2017: A Youth Risk Behavior Survey (YRBS) study
- Title:
- Changes in Adolescent Binge Drinking between 2007 to 2017: A Youth Risk Behavior Survey (YRBS) study
- Abstract:
- Background: Youth binge drinking is a major issue within the United States with consequences including drinking and driving, risky sexual behavior, victimization defined as being physically or verbally victimized at school or home and adverse hormonal function. The objective of this study was to assess the change in adolescent binge drinking between 2007 and 2017. Methods: The Youth Risk Behavior Survey (YRBS) is a cross-sectional questionnaire conducted annually to examine self-reported youth risk behaviors. The current study focuses on risk factors for binge drinking as well as change in youth binge drinking between the 2007 and 2017 YRBS surveys. The YRBS is administered to all students within YRBS preselected districts and to standardize variation in Race and Ethnicity, gender, and grade between the 62 high school districts. The primary research outcome was binge drinking classified as a respondent who answered yes to Have you had more than 5 drinks during one drinking session in the past 30 days. The 10 year difference in frequency of demographic and risk behavior questions including alcohol consumption, physical activity, <5 hours sleep, trying cigarettes, trying various drugs and feeling sad or hopeless were calculated for total survey respondents and respondents who self-classified as binge drinkers in each year. A chi-squared analysis was used to assess the probability of association between binge drinking and demographic groups or survey questions within a the YRBS sampled population. Finally, an adjusted logistic regression was used to model whether binge drinking was statistically associated with year surveyed. Results: The difference in frequency of binge drinking within the past 30 days was 26% in 2007 versus 13.5% among 2017 survey respondents, which represents a >48% decrease between samples. The survey results showed a 33% reduction in students who reported trying alcohol and a 20% reduction in trying alcohol before age 13. A univariate analysis of other risk behavior questions with a statistically significant change over 10 years included a decrease in the use of cigarettes, cocaine, heroin, and other drugs surveyed. There has also been a 33% increase in feelings of sadness or hopelessness between the surveyed populations. Discussion: The current study supports research demonstrating a reduction in binge drinking among U.S. youth. Overall, high school students reported to be engaging less in drug and alcohol-related risk factors. The hypothesized reasons for this reduction include better legal enforcement of vendors and venues, rise of new technology of the internet and social media that provide alternative sources of entertainment, a decreased glamorization of alcohol consumption and the development of other ways to spent time.
- Keyword:
- adolescents , binge drinking, alcohol, risky behavior
- Subject: MESH:
- Binge Drinking, Adolescent Behavior
- Creator:
- Bukowska, Maria
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-05-12
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
- Title:
- Child Access Prevention Firearm Laws and Firearm Fatalities Among Children Aged 0 to 14 Years, 1991-2016
- Original Bibliographic Citation:
- Azad HA, Monuteaux MC, Rees CA, et al. Child Access Prevention Firearm Laws and Firearm Fatalities Among Children Aged 0 to 14 Years, 1991-2016. JAMA Pediatr. 2020;174(5):463469. doi:10.1001/jamapediatrics.2019.6227
- Abstract:
- Public Health Relevance/Background: Firearm violence in the United States is a pressing public health issue. In children, firearm violence is less-often discussed, and there has been less research surrounding pediatric firearm fatalities compared to those in adults. Yet, there was a 38% increase in pediatric firearm fatalities from 2009 to 2016. Using a Haddon Matrix helps determine ways to curb firearm violence, and attempts to change the environment surrounding firearm storage are the cornerstone of firearm laws called Child Access Prevention (CAP) laws. Some pertain to adults giving firearms to children (recklessness laws), while others pertain to the improper storage of firearms in the home (negligence laws). Prior research on CAP laws has been lacking, given a small number of years after implementation of the laws, and only early post-implementation data. Understanding the effect of CAP laws on pediatric firearm fatalities in the United States is critically important in addressing injury prevention in children. Methods: This is a state-level, ecologic panel study using negative binomial regression to analyze differences in state pediatric firearm fatality rates performed on data from the United States on children ages 0-14 years between 1991 and 2016. The main exposure was implementation of two categories of state CAP laws: recklessness and negligence laws. Rates of firearm fatalities across all intents and by specific intent (homicide, suicide, unintentional) per 100,000 children ages 0-14 years was the primary outcome. A population-attributable fraction was calculated with respect to any negligence law and the most stringent form of negligence law. Results: Twenty-five states passed CAP laws between 1989 and 2000. Over the 26-year period, there were 13,967 firearm fatalities in children ages 0-14 years old. Recklessness laws were not associated with changes in pediatric firearm fatality rates. Negligence laws were associated with significant reductions in firearm fatalities in children 0-14 years old. Negligence laws were associated with a 13% reduction in all firearm fatalities (95% CI -18%, -7%), a 15% reduction in firearm homicides (95% CI -22%, -7%), a 12% reduction in firearm suicides (95% CI -20%, -2%), and a 13% reduction in unintentional firearm fatalities (95% CI -24%, -1%). The most stringent negligence laws were associated with unintentional firearm fatality reductions of 59% (95% CI -68%, -49%). 3,929 deaths (29% of all firearm deaths) could be attributed to states not having passed the most stringent form of negligence CAP laws. Discussion: Our study showed that recklessness laws were not associated with differences in firearm fatality rates, but that negligence laws were associated with lower overall rates of firearm fatalities, and lower rates of firearm homicides, suicides, and unintentional deaths. More stringent negligence laws were associated with larger reductions in fatality rate. Importantly, our study showed a reduction in pediatric firearm homicides with negligence CAP laws, the first study to show such a finding. Applying the Bradford-Hill criteria of causality to the existing evidence shows that the relationship between CAP laws and reduced pediatric firearm mortality has evidence for strength, biological gradient, specificity, consistency, and analogy, all of which argue in favor of a causal relationship. However, this is an observational study and we cannot determine causality from this form of study. A population-attributable fraction implied that up to 3,929 pediatric firearm fatalities could have been avoided with the passage of the strongest form of negligence law in all 50 states.
- Keyword:
- firearm, firearm fatalities
- Subject: MESH:
- Firearms, Child Mortality, Infant Mortality
- Creator:
- Azad, Hooman Alexander, Monuteaux, Michael C., Rees, Chris A., Siegel, Michael, Mannix, Rebekah, Lee, Lois K., Sheehan, Karen M, Fleegler, Eric W.
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2019-04-28
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
- Original Identifier:
- (DOI)10.1001/jamapediatrics.2019.6227
- Title:
- Provider, Recipient and Caregiver Perspectives on Cardiovascular Disease and Related Risk Factors after Liver Transplantation: A Qualitative Study
- Abstract:
- Introduction: Liver transplant (LT) is the only life-saving therapy for end-stage liver disease stemming from a multitude of causes though cardiovascular disease (CVD) is the leading cause of early (<1 year) mortality, and the third leading cause of late (> 1 year) mortality after LT. (1-5) This study examined liver transplant recipient (LTR), caregiver, and provider perspectives on CVD after transplant. Barriers to proper care have not been identified for each group and we do not know how each group would describe these barriers. Methods: We conducted seven focus groups to better understand these barriers. The focus groups lasted 90 minutes and were split based on LTR, caregiver, and provider-specialty. The transcriptions for these focus groups were coded. Results: Four major themes found across all groups and are as follows: the lack of awareness of CVD risk after LT, the lack of confidence in ability to provide proper care to LTRs, barriers to care without transplant center review, and barriers caused by having to touch base with multiple providers on the complex care team. Conclusions: Potential solutions to eliminate these barriers include increased education on the risk factors of CVD amongst LTRs done by the transplant team, EMR alerts for providers, increased utilization of the transplant coordinator and the transplant pharmacist, multidisciplinary team meetings to discuss patients care plans, and an additional document detailing the roles of each member of the LTRs care team.
- Keyword:
- liver disease, cardiovascular disease, liver transplant
- Subject: MESH:
- Liver Diseases, Cardiovascular Diseases, Liver Transplantation, Communication Barriers
- Creator:
- Adamski, Lindsay
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-05-18
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Masters Thesis
- Title:
- Transitional Care for Trauma Surgery: A Scoping Review
- Keyword:
- Transitional Care, Trauma Surgery, Scoping Review
- Subject: MESH:
- Hospital to Home Transition, Continuity of Patient Care, Transitional Care, Patient Protection and Affordable Care Act, Wounds and Injuries
- Creator:
- Baskaran, Archit Bharathwaj, Silver, Casey Marie, Jang, Angie, Wafford, Q. Eileen
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Review
215. [Archived].docx
- Title:
- [Archived].docx
- Keyword:
- Transitional Care, Trauma Surgery, Scoping Review
- Creator:
- Baskaran, Archit Bharathwaj, Silver, Casey Marie, Jang, Angie, Wafford, Q. Eileen
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Research Paper
216. [Archived].docx
- Title:
- [Archived].docx
- Keyword:
- Transitional Care, Trauma Surgery, Scoping Review
- Creator:
- Baskaran, Archit Bharathwaj, Silver, Casey Marie, Jang, Angie, Wafford, Q. Eileen
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Research Paper
- Title:
- 2021-2022 Series 06 NUCATS Dealing with Mentoring Challenges
- Description:
- Describe challenges in that commonly occur in mentoring relationships. Identify strategies for overcoming mentoring challenges. Identify a mentoring challenge that you will address.
- Keyword:
- NUCATS, Mentoring, Mentoring challenges, Mentoring relationships
- Subject: MESH:
- Mentoring, Mentors
- Creator:
- Lagu, Tara, Evans, Charlesnika T
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2022-03-10
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/3.0/us/
- Resource Type:
- Presentation
- Title:
- 2021-2022 Series 05 NUCATS Cultural Awareness to Enhance Mentoring Across Differences
- Description:
- Increase awareness of our own social identities and our perspectives about others social identities (i.e.,: race/ethnicity, gender, social class/socioeconomic status, sexual orientation, (dis)abilities, and religion). Recognize the impact of conscious and unconscious assumptions, preconceptions, biases, and prejudices on the mentor-mentee relationship and acquire skills to manage them. Identify concrete strategies for learning about others social identities and improving mentor-mentee relationships through culturally responsive mentoring.
- Keyword:
- NUCATS, Mentoring
- Subject: MESH:
- Mentoring, Mentors, Cultural Competency
- Creator:
- McGee, Rick, Kandula, Namratha R
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2022-02-23
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/3.0/us/
- Resource Type:
- Presentation
- Title:
- 2021-2022 Series 04 NUCATS Fostering Independence/Transitioning your Mentee to Independence
- Description:
- Define Independence, its core elements, and how they change over time. Employ various strategies to build mentee confidence, establish trust, and foster independence. Identify benefits and challenges of fostering independence.
- Keyword:
- NUCATS Mentoring , Independence, Mentee
- Subject: MESH:
- Mentoring, Mentors
- Creator:
- Greenland, Philip, Cella, David
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2022-02-10
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/3.0/us/
- Resource Type:
- Presentation
- Title:
- Analysis Considerations for Race, Ethnicity, and Gender Variables
- Abstract:
- The Department of Preventive Medicines (DPM) Working Group on Response to Structural Racism in Research, in collaboration with several members of the Division of Biostatistics, developed these considerations for best practices when summarizing and analyzing relevant demographic variables in Human Subjects Research. These considerations serve as guidelines and recommendations. They are not binding in any way. We recognize research studies each have unique needs, and there is no single set of best practices that would apply to all studies.
- Keyword:
- race, ethnicity, gender, inclusion, research, analysis, data capture
- Subject: MESH:
- Ethnic and Racial Minorities, Data Analysis, Gender Identity, Data Collection
- Creator:
- Ciolino, Jody Dyan, Kershaw, Kiarri N.
- Contributor:
- Northwestern Universitys Department of Preventive Medicines Working Group on Response to Structural Racism, Carnethon, Mercedes R, Granata IV, Frank Anthony, Gray, Elizabeth, Huffman, Mark D, Jones, Molly, Rodriguez, Monica, Neubauer, Leah C, Scholtens, Denise M
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2022-01-21
- Rights:
- http://creativecommons.org/licenses/by-sa/3.0/us/
- Resource Type:
- Support of Research
- Title:
- Considerations for Capturing of Race, Ethnicity, and Gender Data
- Abstract:
- The Department of Preventive Medicines (DPM) Working Group on Response to Structural Racism in Research surveyed multiple data dictionaries within DPM and beyond (e.g., Feinberg School of Medicine [FSM], United States Census, and the National Institutes of Health [NIH] reporting requirements). We assessed common practice and aggregated ideas from these sources to develop these considerations for best practices when capturing relevant demographic variables in Human Subjects Research. These considerations serve as guidelines and recommendations. They are not binding in any way. We recognize research studies each have unique needs, and there is no single set of best practices that would apply to all studies.
- Keyword:
- race, ethnicity, gender, inclusion, research, analysis, data capture
- Subject: MESH:
- Data Analysis, Ethnic and Racial Minorities, Gender Identity, Data Collection
- Creator:
- Ciolino, Jody Dyan, Kershaw, Kiarri N.
- Contributor:
- Northwestern Universitys Department of Preventive Medicines Working Group on Response to Structural Racism
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2022-01-21
- Rights:
- http://creativecommons.org/licenses/by-sa/3.0/us/
- Resource Type:
- Support of Research
- Title:
- Meta-Analysis: When You Can Do It, When You Can't, and What Info You Need
- Keyword:
- Statistically Speaking Slides
- Subject: MESH:
- Meta-Analysis as Topic, Systematic Reviews as Topic
- Creator:
- Collaboration Center, Biostatistics, Muhammad, Lutfiyya NaQiyba
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2022-01-12
- Rights:
- All rights reserved
- Resource Type:
- Lectures
- Title:
- Considerations for Choosing Covariates in Clinical Research
- Keyword:
- Statistically Speaking Slides
- Subject: MESH:
- Analysis of Variance, Research Design
- Creator:
- Collaboration Center, Biostatistics, Bonner, Lauren Balmert
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-12-09
- Rights:
- All rights reserved
- Resource Type:
- Lectures
- Title:
- Capturing Racial and Ethnic Data and Considerations for Analysis
- Keyword:
- Statistically Speaking Slides
- Subject: MESH:
- Data Analysis, Ethnic and Racial Minorities
- Creator:
- Collaboration Center, Biostatistics
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2022-02-03
- Rights:
- All rights reserved
- Resource Type:
- Lectures
- Title:
- Considerations when Leveraging Electronic Health Records for Causal Inference: A "Create-Your-Own-Data" Adventure
- Keyword:
- Statistically Speaking Slides
- Subject: MESH:
- Causality, Electronic Health Records, Data Analysis
- Creator:
- Collaboration Center, Biostatistics, Petito, Lucia Catherine
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2022-03-03
- Rights:
- All rights reserved
- Resource Type:
- Lectures
- Title:
- Maintenance of Diet and Activity Behaviors and Weight Loss After Intensive Lifestyle Intervention Scoping Review Protocol
- Abstract:
- Rationale: Although intensive lifestyle interventions tend to be successful at initiating weight loss, maintaining weight loss after withdrawal of intervention is more challenging. Also, it is unclear to what degree behavioral changes in dietary intake and physical activity that were made during weight loss initiation persist after treatment discontinuation and account for the observed variability in weight loss maintenance. A primary barrier to optimizing lifestyle interventions for long-term sustained improvement is the current lack of a coherent theoretical and methodological foundation for operationalizing maintenance. Indeed, there is variability in how researchers define, measure, and evaluate maintenance of both weight regulatory behaviors and weight loss following intervention. This variability in operationalizing maintenance could have significant implications for designing and optimizing interventions to achieve long-term maintenance. A synthesis of the available evidence on post-intervention behavioral weight loss maintenance is needed to lay a foundation that future researchers can use to appropriately design and implement interventions that produce meaningful, sustained healthful improvements in weight.
- Keyword:
- Protocol
- Subject: MESH:
- Body Weight Maintenance, Health Behavior, Diet, Food, and Nutrition, Exercise
- Creator:
- Daly, Elyse Renee, Battalio, Sam, Spring, Bonnie, Wafford, Q. Eileen, Pfammatter, Angela Fidler, Jovanovic, Christine Ernestine Schaak, Alshurafa, Nabil, Kalam, Faiza, Stump, Tammy Kay
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by-nc-nd/3.0/us/
- Resource Type:
- Review
- Title:
- Dried blood spots to measure the association between psychosocial factors and cardiovascular disease biomarkers: a scoping review
- Abstract:
- Scoping Review Question: What studies have used dried blood spots (DBS) to quantify cardiovascular disease (CVD) biomarkers in association with psychosocial factors? Psychosocial factors will include depression, anxiety, low socioeconomic status/poverty, incarceration, perceived discrimination, and other factors identified by this review.
- Keyword:
- dried blood spots, biomarkers, cardiovascular disease, psychosocial factors, population health
- Subject: MESH:
- Dried Blood Spot Testing, Cardiovascular Diseases, Psychosocial Functioning
- Creator:
- Jacobson, Tyler Andrew, Schwartz, William Alexander, Zhang, Runze, Wafford, Q. Eileen, Nunes, Denise A, Hirschhorn, Lisa Ruth, Khan, Sadiya Sana, Miller, Greg, McDade, Thomas, Funk, William E
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2022-01
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Review
- Title:
- Ethics of contributor roles ontologies and taxonomies - Scoping review protocol
- Abstract:
- Background: This scoping review follows up on the results of an exploratory review of the literature (Hosseini, 2021) about ethics of Contributor Role Ontologies and Taxonomies (CROTs). Given the significance of CROTs in scholarly publications, the current iteration will address methodological limitations of the exploratory review and will also capture sources published more recently.Objectives: This review aims to 1) synthesize the published literature about ethical aspects of CROTs and 2) categorize discussed aspects under specific ethical themes.Methods: Upon reviewing each source, information related to ethical aspects of CROTs will be synthesized to answer research questions. Sources that discuss ethical aspects of CROTs in a significant way in English will be included. Four indices (Scopus, Web of Science, PubMed, Google Scholar) will be searched without restriction on publication dates. Data will be charted in terms of mentioned research area(s), discussed CROTs, discussed ethical aspects (and in case of availability, other note-worthy information such as used normative approach, mentioned stakeholders, and provided solutions/recommendations will also be captured for further analysis).Results: Review results will be published open access in the peer-reviewed journal of Accountability in Research. Subsequently, the review results will inform the development of a survey to explore the views of the research community about the ethical evolution of CROTs.
- Keyword:
- Ethics, Contributor Role Ontologies and Taxonomies, Collaborative Research, Meta-Research
- Subject: MESH:
- Authorship, Ethics
- Creator:
- Hosseini, Mohammad, Gordijn, Bert, Wafford, Q. Eileen, Holmes, Kristi
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Review
- Title:
- 2021-2022 Series 03 NUCATS Cultural Awareness to Enhance Mentoring Across Differences
- Description:
- - Increase awareness of our own social identities and our perspectives about others social identities (i.e.,: race/ethnicity, gender, social class/socioeconomic status, sexual orientation, (dis)abilities, and religion). - Recognize the impact of conscious and unconscious assumptions, preconceptions, biases, and prejudices on the mentor-mentee relationship and acquire skills to manage them.- Identify concrete strategies for learning about others social identities and improving mentor-mentee relationships through culturally responsive mentoring.
- Keyword:
- NUCATS, Mentoring
- Subject: MESH:
- Mentoring, Mentors, Cultural Competency, Social Identification
- Creator:
- McGee, Rick, Kandula, Namratha R
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2022-01-13
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/3.0/us/
- Resource Type:
- Presentation
- Title:
- Abstract - Development of a Graph Model for the OMOP Common Data Model
- Abstract:
- Current phenotyping and systems biology research requires not only integration of large volumes of Electronic Health Record (EHR) and multi-omics data, but also capturing the multitudes of relations among the concepts. Graph databases have emerged as a promising technology for such tasks, supporting not only local analysis but also global analysis leveraging graph algorithms like Centrality, Community Detection, Path Finding or Node Embeddings.Unfortunately, EHR data is rarely available in a graph format. While a nave row-to-node conversion is possible, the resulting graph is typically attribute-heavy, resulting in suboptimal performance. To address this limitation, we developed a modelling method to convert data form the Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) to the Neo4j [www.neo4j.com] graph property model.
- Keyword:
- Graph Database, SCRIPT study, OMOP CDM
- Subject: MESH:
- Models, Theoretical
- Subject: LCSH:
- Graph databases
- Creator:
- Kang, Mengjia, Alvarado-Guzman, Jose A., Rasmussen, Luke, Starren, Justin B
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Abstracts
- Title:
- Development of a Graph Model for the OMOP Common Data Model
- Keyword:
- Graph Database, OMOP CDM, Graph schema, SCRIPT study, SCRIPT project, Neo4j
- Subject: MESH:
- Models, Theoretical
- Subject: LCSH:
- Graph databases
- Creator:
- Kang, Mengjia, Rasmussen, Luke, Starren, Justin B, Alvarado-Guzman, Jose A
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Poster
- Title:
- Defining in-field overeating: A scoping review
- Abstract:
- Objectives: This scoping review aims to broadly identify how overeating is defined and employed in real-world experimental and observational settings, as well as how overeating correlates to health outcomes. Specifically, we will review studies done in adult human populations. We will answer the following questions: How is overeating conceptually defined? (ex. overconsumption of calories vs. macronutrients, timing/skipping of meals, association with emotional or mental health state, etc.) What thresholds define overeating? (ex. number of calories/calories from a specific macronutrient, specific number of meals exceeded, definition of snacking, specific emotional or mental health factors etc.) What, if any, evidence exists that certain thresholds are more/less valid? What tools are used to measure eating/overeating? (self-reported vs researcher-guided recall, sensor data, food diary/data entry etc.) How does overeating in the real world correlate to health outcomes?
- Keyword:
- overeating, scoping review, protocol
- Subject: MESH:
- Eating, Hyperphagia
- Creator:
- Hussain, Tasmeen, Stump, Tammy Kay, Wafford, Q. Eileen, Alshurafa, Nabil
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Study Design
- Title:
- 2021-2022 Series 02 NUCATS Work-Life Integration
- Description:
- Explores different ways to conceptualize the intersection of important domains in our lives (e.g. work-life integration vs. work-life balance vs. an integrated life). Identifies priorities and goals for integrating these important domains both at work and outside of work. Discusses the challenges and opportunities related to our current remote working environment, and how this can be leveraged to achieve a more integrated life.
- Keyword:
- NUCATS, Mentoring
- Subject: MESH:
- Mentoring, Mentors, Work-Life Balance
- Creator:
- Allen, Norrina Bai, O'Brien, Matthew James
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-11-11
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/3.0/us/
- Resource Type:
- Presentation
- Title:
- Mapping the OMOP Common Data Model to Neo4j for Pneumonia Therapy Response: SCRIPT Case Study
- Keyword:
- Graph Database, OMOP CDM, Graph Model, SCRIPT
- Subject: MESH:
- Pneumonia--therapy, Data Analysis
- Creator:
- Kang, Mengjia, Rasmussen, Luke
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- All rights reserved
- Resource Type:
- Presentation
- Title:
- 2021-2022 Series 01 NUCATS Establishing and Aligning Expectations
- Description:
- In this workshop presentation, viewers will: Examine existing expectations in your current mentoring relationships; question which expectations need to be revisited or discussed. Recognize and describe how one can apply a variety of tools to promote alignment in mentoring relationships. Choose 1-2 behavior changes you can enact in the next 3-6 months to improve alignment in your mentoring relationships.
- Keyword:
- Mentoring, NUCATS
- Subject: MESH:
- Mentoring, Mentors
- Creator:
- Cameron, Kenzie A, Carnethon, Mercedes R
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-10-14
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/3.0/us/
- Resource Type:
- Presentation
- Title:
- Recent advances in gene therapy for atrial fibrillation
- Original Bibliographic Citation:
- Yoo S, Geist GE, Pfenniger A, Rottman M, Arora R. Recent advances in gene therapy for atrial fibrillation. J Cardiovasc Electrophysiol. 2021;32:28542864.
- Abstract:
- Atrial fibrillation (AF) is the most common heart rhythm disorder in adults and a major cause of stroke. Unfortunately, current treatments for AF are suboptimal as they are not targeting the molecular mechanisms underlying AF. In this regard, gene therapy is emerging as a promising approach for mechanismbased treatment of AF. In this review, we summarize recent advances and challenges in gene therapy for this important cardiovascular disease.
- Keyword:
- Gene Therapy, Atrial Fibrillation
- Subject: MESH:
- Atrial Fibrillation, Genetic Therapy
- Creator:
- Rottmann, Markus, Yoo, Shin, Geist, Gail Elizabeth, Pfenniger, Anna, Arora, Rishi K
- Publisher:
- Journal of Cardiovascular Electrophysiology, DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-05-30
- Rights:
- All rights reserved
- Resource Type:
- Journal Article
- Original Identifier:
- (DOI) 10.1111/jce.15116
- Title:
- Mental health interventions for young people delivered through social media: Protocol for a scoping review
- Abstract:
- Objectives: The objective of this scoping review is to identify and review empirical research on social media-based interventions aimed at improving mental health conditions in adolescents and young adults. Sincesocial media is a consistently evolving term, a secondary objective of this review is to identify thequalities of platforms labeled as social media. We limit the scope of interventions to those that are entirely, or mostly, delivered through social media and to studies examining the intentional implementation of a mental health intervention (excluding naturalistic intervention, peer support).
- Keyword:
- scoping review, protocol
- Subject: MESH:
- Social Media, Social Networking, Mental Health, Child, Adolescent, Health Promotion
- Creator:
- Kruzan, Kaylee P, Williams, Kofoworola DA, Meyerhoff, Jonah, O'Dwyer, Linda, Mohr, David C, De Choudhury, Munmun, Yoo, Dong Whi
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc/3.0/us/
- Resource Type:
- Study Design
- Title:
- Navigating the Road Ahead (The 21st Health Sciences Lively Lunchtime Discussion)
- Description:
- Handout prepared for a brief (traditional) annual update of interesting and noteworthy trends in the health publishing and health information sectors that occurred or were noticed since the 2020 Health Sciences Lively Lunch at the Charleston Conference: Issues in Book and Serial Acquisition. (the 21st Lively Lunch took place on Thursday, November 4, 2021 in a hybrid fashion).
- Keyword:
- Charleston Conference
- Subject: MESH:
- Libraries, Medical
- Subject: LCSH:
- Scholarly publishing
- Creator:
- Kubilius, Ramune K.
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-10-21
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/3.0/us/
- Resource Type:
- Presentation
- Title:
- Return to work model after injury or illness: A Scoping Review Protocol
- Abstract:
- After injury or illness, return to work (RTW) is important for previously-employed patients, and is positively associated with functional recovery and economic status.1-5 Failure to return to work (RTW) following illness or injury is often, both theoretically and operationally, equated with work disability.6 In the past three decades, biomedical, social construction, and biopsychosocial models have proposed to describe the process and potential factors that influence human responses to work and the development of work disability. 7 Within the biomedical perspective, disability is produced by a medical condition, which deviates individuals from normal biomedical function or structure. 6 8 Factors such as context and environment are not considered. However, in the social construction paradigm, disability is viewed as a combination of activities, relationships, individual attributes, and conditions arising mainly from the social environment.8 Thus, disability depends on a societal response in a given context. The biopsychosocial models approach disability from both the social and the biomedical paradigms, which provide the most comprehensive view to discuss work disability. From the biopsychosocial point of view, multiple factors potentially affect RTW. The occupational disability model, which includes medical status (such as neurologic, cardiovascular), physical capability (physical status, work tolerance), work demands (biomechanical, psychological), and psychological/behavioral resources (workers traits, psychological readiness), is an example of an early biopsychosocial approach.9 Many other models have been proposed to understand RTW from the biopsychosocial approach, such as the Institute of Medicine model of disability,10 the International Classification of Functioning, Disability, and Health (ICF)/the expanded ICF model,11 the cancer and work model,12 as well as the readiness for return to work model. The scoping review aims to 1) identify existing RTW models using biopsychosocial approach, 2) compare and contract these models, and 3) synthesis these models and proposed a comprehensive model.
- Keyword:
- scoping review, model, return to work, protocol
- Subject: MESH:
- Return to Work, Rehabilitation, Vocational
- Creator:
- Su, Han, Park, Mirang, Thompson, Hilaire J., O'Dwyer, Linda
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-10-21
- Rights:
- All rights reserved
- Resource Type:
- Review
- Title:
- Evaluating Current Practices in Primary Care Pediatrics Education: A Scoping Review Protocol
- Abstract:
- As methods and research in the field of medical education are constantly growing and evolving, new practices in teaching are being applied to multiple specialties and subspecialties across medicine, including pediatrics. The field of primary care pediatrics is one that encompasses a wide breadth of information, and given the ever-changing landscape of medical education, evaluation of recent changes or developments in how primary care pediatrics is taught at the resident physician and medical student level could help to identify areas for further improvement. In order to identify recent changes in the way that primary care pediatrics teaching occurs and what areas could be improved, we ask the question: what qualitative, quantitative, or mixed-methods research exists regarding primary care pediatrics education for medical students and resident trainees?
- Keyword:
- scoping review, primary care, pediatrics
- Subject: MESH:
- Pediatrics--education, Physicians, Primary Care--education
- Creator:
- Bruton, Lucas Baughn, Quadri, Maheen, O'Dwyer, Linda
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-09
- Rights:
- All rights reserved
- Resource Type:
- Review
- Title:
- TableS4_Biophysical_Properties_of_KCNQ2-variants_Homozygous.xlsx
- Keyword:
- KCNQ2
- Creator:
- George Jr., Alfred L.
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by-nc/3.0/us/
- Resource Type:
- Dataset
- Title:
- TableS5_Biophysical_Properties_of_KCNQ2-variants_Heterozygous.xlsx
- Keyword:
- KCNQ2
- Creator:
- George Jr., Alfred L.
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by-nc/3.0/us/
- Resource Type:
- Dataset
- Title:
- TableS6_Biophysical_Properties_of_KCNQ2-variants_Homozygous_Retigabine.xlsx
- Keyword:
- KCNQ2
- Creator:
- George Jr., Alfred L.
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by-nc/3.0/us/
- Resource Type:
- Dataset
- Title:
- TableS7_Biophysical_Properties_of_KCNQ2-variants_Heterozygous_Retigabine.xlsx
- Keyword:
- KCNQ2
- Creator:
- George Jr., Alfred L.
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by-nc/3.0/us/
- Resource Type:
- Dataset
- Title:
- TableS3_Biophysical_Properties_of_KCNQ2-variants_by_Manual_and_Automated_patch_clamp.xlsx
- Keyword:
- KCNQ2
- Creator:
- George Jr., Alfred L.
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by-nc/3.0/us/
- Resource Type:
- Dataset
- Title:
- Vanoye KCNQ2 data tables Oct 15, 2021
- Description:
- These are data tables in Excel format to accompany submission of an article entitled: High-throughput Evaluation of KCNQ2 Variants Reveals Functional and Pharmacological Heterogeneity
- Original Bibliographic Citation:
- Pending
- Abstract:
- Hundreds of KCNQ2 variants have been identified by genetic testing of children with early onset epilepsy and/or developmental disability. Voltage-clamp recording from heterologous cells has proved useful for establishing deleterious functional effects of KCNQ2 variants, but procedures adapting these assays for standardized, higher throughput data collection and reporting are lacking. In this study, we employed automated patch clamp recording to assess in parallel the functional and pharmacological properties of 79 missense and 2 in-frame deletion variants of KCNQ2. Among the variants we studied were a training set of 18 pathogenic variants previously studied by voltage-clamp recording, 24 mostly rare population variants, and 39 disease-associated variants with unclear functional effects. Variant KCNQ2 subunits were transiently expressed in a cell line stably expressing KCNQ3 to reconstitute the physiologically relevant channel complex. Variants with severe loss-of-function were also co-expressed 1:1 with WT KCNQ2 in the KCNQ3 cell line to mimic the heterozygous genotype and assess dominant-negative behavior. In total, we analyzed electrophysiological data recorded from 9,480 cells. The functional properties of WT KCNQ2/KCNQ3 channels and pharmacological responses to known blockers and activators determined by automated patch clamp recording were highly concordant with previous findings. Similarly, functional properties of 18 known pathogenic variants largely matched previously published results and the validated automated patch clamp assay. Many of the 39 previously unstudied disease-associated KCNQ2 variants exhibited prominent loss-of-function and dominant-negative effects, providing strong evidence in support of pathogenicity. All variants, exhibit response to retigabine (10 M), although there were differences in maximal responses. Variants within the ion selectivity filter exhibited the weakest responses whereas retigabine had the strongest effect on gain-of-function variants in the voltage-sensor domain. Our study established a high throughput method to detect deleterious functional consequences of KCNQ2 variants. We demonstrated that dominant-negative loss-of-function is a common mechanism associated with missense KCNQ2 variants but this does not occur with rare population variation in this gene. Importantly, we observed genotype-dependent differences in the response of KCNQ2 variants to retigabine.
- Keyword:
- KCNQ2, Vanoye
- Creator:
- George Jr., Alfred L.
- Contributor:
- Vanoye, Carlos Guillermo
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Date Created:
- October 17, 2021
- Rights:
- http://creativecommons.org/licenses/by-nc/3.0/us/
- Title:
- Health Sciences eBooks in 2021: Availability, Challenges, and Trends
- Description:
- Originally published in: Kubilius, Ramune K. and Butzen-Cahill, Tim. Health Sciences Books in 2021: Availability, Challenges, and Trends. Against the Grain. 2021; 33(4):14-16. https://www.charleston-hub.com/2021/09/health-sciences-ebooks-in-2021-availability-challenges-and-trends. PDF of article posted with publisher's permission.
- Original Bibliographic Citation:
- Kubilius, Ramune K. and Butzen-Cahill, Tim. Health Sciences Books in 2021: Availability, Challenges, and Trends. Against the Grain. 2021; 33(4):14-16. https://www.charleston-hub.com/2021/09/health-sciences-ebooks-in-2021-availability-challenges-and-trends.
- Keyword:
- ebooks, e-books
- Subject: MESH:
- Libraries, Medical
- Subject: LCSH:
- Collection development (Libraries), Books
- Creator:
- Kubilius, Ramune K., Butzen-Cahill, Tim
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-09
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Article
- Title:
- Holistic Thinking in Collections and Collection Development
- Description:
- Poster talk presented during the Health Sciences Librarians of Illinois (HSLI) virtual conference on October 27, 2021.
- Abstract:
- Libraries' sizes and organizational structures differ when it comes to assignment of official responsibilities for collection development and management. Publisher and vendor questionnaires ask whether one has final responsibility or an advisory role in decision-making. An argument can be made that we all can and should have a role in knowing about and providing information resources for our primary users, no matter our official job responsibilities. And more. Especially in today's scholarly communications and publishing landscape. A few use cases will be shared that make the argument that we all have access to and can take advantage of various opportunities- to monitor, watch, be informed about, act on, or "connect the dots" in health sciences collections-related work, in our libraries, in our parent institutions, and professionally. As new publishing trends bring new resources to the forefront, many that are free, traditional print collections and online subscriptions no longer should limit our definitions of collections-related work. Official duties and job titles should not limit us from thinking and acting holistically, in order to also take advantage of opportunities provided by interim responsibilities, committees and working groups. The objective is to look for interconnections, share and repurpose work, where possible, and to think holistically.
- Keyword:
- collection development
- Subject: MESH:
- Libraries, Medical
- Subject: LCSH:
- Collection development (Libraries), Scholarly publishing
- Creator:
- Kubilius, Ramune K.
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-10-27
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/3.0/us/
- Resource Type:
- Poster
- Title:
- TN1_participants_essential_data_7_14_19.xlsx
- Keyword:
- thematic fit
- Creator:
- Aveni, Katie, Roberts, Angela
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Dataset
- Title:
- Thematic_norms_analyses_final.pdf
- Keyword:
- thematic norms
- Creator:
- Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Software or Program Code
- Title:
- 007_Verb_and_ObjAnalysis_final.txt
- Keyword:
- eye tracking
- Creator:
- Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Software or Program Code
- Title:
- 007_VerbAnalysis_final.txt
- Keyword:
- eye tracking
- Creator:
- Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Software or Program Code
- Title:
- 007_LookAnalysis_eR_final.txt
- Keyword:
- eye tracking
- Creator:
- Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Software or Program Code
- Title:
- 007_ObjAnalysis_final.txt
- Keyword:
- eye tracking
- Creator:
- Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Software or Program Code
- Title:
- 007_LookTargetAnalysis_eR_final.txt
- Keyword:
- eye tracking
- Creator:
- Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Software or Program Code
- Title:
- 007_AVTanalysis_eR_final.txt
- Keyword:
- eye tracking
- Creator:
- Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Software or Program Code
- Title:
- 007_AgentAnalysis_final.txt
- Keyword:
- eye tracking
- Creator:
- Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Software or Program Code
- Title:
- LCAN_007_NP_demo_data_for_upload.xlsx
- Keyword:
- neuropsychological testing, language prediction
- Creator:
- Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Dataset
- Title:
- 10_17_19_AVT_SentenceDur_Extended.xls
- Keyword:
- eye-tracking
- Creator:
- Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Dataset
- Title:
- 10_17_19_LookAt_SentenceDur_Extended.txt
- Keyword:
- eye-tracking
- Creator:
- Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Dataset
263. readme.txt
- Title:
- readme.txt
- Keyword:
- eye-tracking
- Creator:
- Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Other
- Title:
- Association of genetic polymorphisms with local steroid metabolism in human benign breasts, Polymorphisms and Breast Fluid Steroids
- Abstract:
- Purpose: Although alterations of concentrations in circulating steroids have been linked to single nucleotide polymorphisms (SNPs) of steroidogenic enzymes, we hypothesized that SNPs of such enzymes located within the breast affect local steroid concentrations more than products of such SNPs absorbed from the circulation.Methods: Steroids (estradiol, estrone, testosterone, androstenedione, DHEA, DHEA sulfate, progesterone) in nipple aspirate fluid (NAF) were purified by HPLC and they along with serum steroids were quantified by immunoassays. Polymorphisms of the transporter SLCO2B1 and enzymes HSD3B1, CYP19A1, HSD17B12, AKR1C3, CYP1B1, and SRD5A1 were measured in white blood cell DNA. Results: Steroid concentrations in NAF of subjects with homozygous minor genotypes differed from those with heterozygotes, i.e., SLCO2B1 (rs2851069) decreased DHEAS (p = 0.04), HSD17B12 (rs11555762) increased estradiol (p <0.004), and CYP1B1 (rs1056836) decreased estradiol (p = 0.017) and increased progesterone (p = 0.05). Also, in serum, CYP19A1 (rs10046 and rs700518) both decreased testosterone (p = 0.02) and SRD5A1 increased androstenedione (p=0.006). Steroids in subjects with major homozygotes did not differ from those with heterozygotes indicating recessive characteristics. Conclusions: In the breast, SNPs were associated with decreased uptake of DHEAS (SLCO2B1), increased estradiol concentrations through increased oxidoreductase activity (HSD17B12), or decreased estradiol concentrations by presumed formation of 4-hydroxyestradiol (CYP1B1). CYP19A1 was associated with decreased testosterone concentrations in serum but had no significant effect on estrogen or androgen concentrations within the breast. The hormone differences observed in NAF were not usually evident in serum, indicating the importance of assessing the effect of these SNPs within the breast.
- Keyword:
- single nucleotide polymorphisms, steroid metabolizing enzymes, human breast
- Subject: MESH:
- Breast, Polymorphism, Genetic , Enzymes, Steroids--metabolism, Nipple Aspirate Fluid
- Creator:
- Chatterton Jr, Robert Treat, Lee, Oukseub, Fought, Angela J, Shidfar, Ali, Heinz, Richard E, Kmiecik, Thomas E, Gann, Peter H, Khan, Seema Ahsan
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Journal Article
- Title:
- Principles of Effective Data Visualization for NU
- Abstract:
- The Principles of Effective Data Visualization reviews how data visualizations can make data more comprehensible; emphasizing trends and patterns that might otherwise be difficult to detect. By the end of the course, attendees will know how different visual cues help make meaning from data, recognize the different types of charts available, feel comfortable with options for telling stories with data, recognize the importance of design elements, such as typography and color in data visualization, and understand the power and importance of data visualizations.
- Keyword:
- data visualization
- Subject: MESH:
- Data Visualization, Data Display, Information Dissemination
- Creator:
- Gutzman, Karen E, Mendoza, Annette Renee, Soulakis, Mao
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-06
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/3.0/us/
- Resource Type:
- Presentation
267. Contextual Factors in Quality Improvement and Implementation Initiatives: A Scoping Review Protocol
- Title:
- Contextual Factors in Quality Improvement and Implementation Initiatives: A Scoping Review Protocol
- Abstract:
- The objective of this scoping review is to map the large body of literature and to describe the range of contextual factors identified. By focusing on existing reviews of contextual factors, this review aims to synthesize the ways in which context has been conceptualized and its components described.
- Keyword:
- contextual factors, quality improvement, scoping review protocol, scoping review
- Subject: MESH:
- Review Literature as Topic, Authorship
- Creator:
- Terwilliger, Iva Alyse, Diaz, Carmen Marina, Grewal, Abhijit Singh, Fancher, Kendall Gregory, O'Dwyer, Linda, O'Leary, Kevin John, Johnson, Julie, Reddy, Madhu
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-09-21
- Rights:
- All rights reserved
- Resource Type:
- Study Design
- Title:
- Hands On Scenario Collection Development
- Abstract:
- Data visualization is used to communicate complex information and explore trends in large sources of data. Compelling data visualization requires thoughtful planning and execution; from understanding the data, choosing the right chart, balancing visual cues, and providing narratives to tell interesting stories. This course gives attendees a strong foundation in the principles of data visualization. In addition attendees will use Microsoft Excel, a common but incredibly powerful tool, to visualize library-relevant data through a series of hands-on activities. Attendees will gain practical and immediately useful skills for visualizing both qualitative and quantitative data.
- Keyword:
- data visualization
- Subject: MESH:
- Data Visualization, Library Collection Development
- Subject: LCSH:
- Collection development (Libraries)
- Subject: Name:
- Microsoft Excel (Computer file)
- Creator:
- Gutzman, Karen E, Mendoza, Annette Renee, Norton, Candace, Belter, Chris
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-06
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/3.0/us/
- Resource Type:
- Handbooks
- Title:
- Supplemental Tables (11) Steroids MS.docx
- Keyword:
- polymorphisms, steroidogenic enzymes, steroids
- Subject: MESH:
- Polymorphism, Genetic, Steroids--metabolism, Enzymes, Breast Neoplasms
- Creator:
- Chatterton Jr, Robert Treat
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Tables
- Title:
- Food Allergy Data Dictionary Coding Guide
- Keyword:
- Coding Guide, Food Allergy, Data Dictionary, Food Allergy Data Commons, Data Commons
- Subject: MESH:
- Food Hypersensitivity, Information Systems
- Subject: LCSH:
- Data dictionaries
- Creator:
- Wlodarski, Mark T
- Contributor:
- Starren, Justin B, Sehgal, Shruti
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc/3.0/us/, All rights reserved
- Resource Type:
- Dictionary
- Title:
- Peripartum care and obesity: A protocol for a scoping review of evidenced-based recommendations and practical modalities for implementation
- Keyword:
- obesity, pregnancy, guidelines
- Subject: MESH:
- Prenatal Care, Pregnancy Complications--prevention & control, Obesity--prevention & control, Pregnancy
- Creator:
- Kominiarek, Michelle, Cassimatis, Irina R, Premkumar, Ashish, Peace, Jack, Toledo, Paloma, O'Dwyer, Linda
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Study Design
- Title:
- Exploring Early Intervention team models and service delivery approaches impact on child and family outcomes: a scoping review
- Keyword:
- Scoping Review Protocol, Early Intervention, Team Models, Service Delivery, Children
- Subject: MESH:
- Developmental Disabilities--prevention & control, Health Services Research, Early Intervention, Educational, Infant, Child, Preschool,
- Creator:
- Stoffel, Ashley, James, Lesley, Trenkle, Jessica, Liddle, Allison, Wafford, Q. Eileen
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Review
- Title:
- Final_thematic_norms_ratings_ARCHARCHIVED.xls
- Keyword:
- thematic role norms, verb motion content norms
- Creator:
- Roberts, Angela, Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Dataset
- Title:
- LCAN_007_motion_content_ratings.xls
- Keyword:
- thematic role norms, verb motion content norms
- Creator:
- Roberts, Angela, Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Dataset
- Title:
- Final_thematic_norms_ratings_ARCHARCHIVED.xls
- Keyword:
- thematic role norms
- Creator:
- Roberts, Angela, Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Dataset
- Title:
- LCAN_007_motion_content_ratings.xls
- Keyword:
- Thematic role and verb motion content norms
- Creator:
- Roberts, Angela, Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Dataset
- Title:
- LCAN_007_motion_content_ratings.xls
- Keyword:
- Thematic role and verb motion content norms
- Creator:
- Roberts, Angela, Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- http://creativecommons.org/licenses/by/3.0/us/
- Resource Type:
- Dataset
- Title:
- Thematic Role and Verb Norms
- Description:
- Normative data for thematic roles and verb motion content. Method details for normative study can be found in the following publication.
- Keyword:
- eye tracking, aging, thematic role norms, visual world paradigm, verb norms
- Creator:
- Roberts, Angela, Aveni, Katie
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
279. GDM metabolite data
- Title:
- GDM metabolite data
- Keyword:
- Gestational Diabetes, Metabolomics, Disorders of glucose metabolism
- Subject: MESH:
- Diabetes, Gestational , Diabetes Complications
- Creator:
- Lowe Jr, William L
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Dataset
- Title:
- Instructions for Installing and Using R Functions
- Keyword:
- R package, Research, Instruction
- Subject: MESH:
- Subject: LCSH:
- R (Computer program language) , Statistics--Data processing
- Creator:
- Chen, Liqi
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-03-10
- Rights:
- http://creativecommons.org/licenses/by-nc/3.0/us/
- Resource Type:
- Resource Guides
- Title:
- Enhancer Malfunction Underlies Transcriptional Dysregulation in Uterine Leiomyoma.pdf
- Abstract:
- Uterine leiomyomas (fibroids) are a major source of gynaecologic morbidity in reproductive age women and are characterised by the excessive deposition of a disorganised extracellular matrix, resulting in rigid benign tumours. Clinically, leiomyoma patients usually present with pelvic pain, urinary incontinence, as well as heavy cyclic and non-cyclic bleeding. Curative treatment options are limited, with hysterectomies currently the only guaranteed treatment to prevent reoccurrence.Uterine fibroid tumours are composed primarily of smooth muscle cells and fibroblasts. They have also been shown to be clonal, with multiple tumours from the same patient sometimes originating from different tumour initiating cells. Leiomyomas fall into four main mutational subtypes: tumours with genetic aberrations in either fumarate hydratase (FH), mediator of transcription subunit 12 (MED12), high mobility group AT-hook 2 (HMGA2), or type IV collagens. Somatic mutations in Mediator complex subunit MED12 have been implicated as the causal genetic lesion in the majority of leiomyoma. The functional consequence of this mutation with respect to altered epigenetic events and subsequent transcriptional dysregulation remains poorly understood.Epigenetic control of gene expression by promoter-distal cis-regulatory elements such as enhancers is an established and important mechanism of gene regulation, with aberrant epigenetic changes at distal sites being implicated in human disease. Despite this, the role of enhancer regulation in uterine leiomyomas remains unexplored. In this study, optimised extraction procedures for fibrotic tissues, coupled with high resolution ChIP-sequencing, promoter capture Hi-C, and RNA-sequencing of matched normal myometrium and diseased leiomyoma tissues, are used to provide an integrative analysis of transcriptional dysregulation mechanisms in leiomyomas. Through the characterisation of the first chromatin interactome in uterine leiomyomas, this study demonstrates that modified enhancer architecture is an important mechanism of transcriptional dysregulation in uterine fibroids.Activator protein 1 (AP-1) is a dimeric transcription factor that responds to varied stimuli and is responsible for the regulation of many cellular processes such as proliferation and differentiation. AP-1 subunits belonging to JUN, FOS and ATF gene families have previously been demonstrated to be down regulated in uterine leiomyomas. This study highlights the link between decreased AP-1 subunit gene expression and modifications in leiomyoma tissue enhancer architecture. The loss of AP-1 expression results in the depletion of AP-1 occupancy on chromatin in leiomyoma tissue samples, which correlates with changes in H3K27 acetylation at distal cis-regulatory elements.Importantly, this study also demonstrates that silencing of AP-1 subunits in primary human uterine smooth muscle cells leads to large-scale transcriptional dysregulation. In addition, loss of AP-1 causes significant alteration to the H3K27Ac cistrome in uterine smooth muscle cells, primarily at promoter-distal sites, thereby partially recapitulating epigenetic changes seen in leiomyoma tissue samples. The data supports the hypothesis that AP-1 plays an important mechanistic role in enhancer maintenance and the loss of AP-1 results in altered enhancer architecture in uterine smooth muscle cells. These findings establish AP-1 driven aberrant enhancer regulation as an important mechanism of leiomyoma disease pathogenesis.
- Keyword:
- Reproductive disorders, Epigenomics, Gene regulation, Chromatin structure, Histone post-translational modifications
- Subject: MESH:
- Uterine Neoplasms, Leiomyoma
- Creator:
- Moyo, Mthabisi Bongani
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-06
- Rights:
- http://creativecommons.org/licenses/by-nc-nd/3.0/us/
- Resource Type:
- Academic Dissertations
- Original Identifier:
- (DOI) 10.21985/n2-vsb2-cm32
- Title:
- Supplementary_tables.xlsx
- Description:
- Supplementary tables for "Enhancer Malfunction Underlies Transcriptional Dysregulation in Uterine Leiomyoma"
- Abstract:
- Uterine leiomyomas (fibroids) are a major source of gynaecologic morbidity in reproductive age women and are characterised by the excessive deposition of a disorganised extracellular matrix, resulting in rigid benign tumours. Clinically, leiomyoma patients usually present with pelvic pain, urinary incontinence, as well as heavy cyclic and non-cyclic bleeding. Curative treatment options are limited, with hysterectomies currently the only guaranteed treatment to prevent reoccurrence.Uterine fibroid tumours are composed primarily of smooth muscle cells and fibroblasts. They have also been shown to be clonal, with multiple tumours from the same patient sometimes originating from different tumour initiating cells. Leiomyomas fall into four main mutational subtypes: tumours with genetic aberrations in either fumarate hydratase (FH), mediator of transcription subunit 12 (MED12), high mobility group AT-hook 2 (HMGA2), or type IV collagens. Somatic mutations in Mediator complex subunit MED12 have been implicated as the causal genetic lesion in the majority of leiomyoma. The functional consequence of this mutation with respect to altered epigenetic events and subsequent transcriptional dysregulation remains poorly understood.Epigenetic control of gene expression by promoter-distal cis-regulatory elements such as enhancers is an established and important mechanism of gene regulation, with aberrant epigenetic changes at distal sites being implicated in human disease. Despite this, the role of enhancer regulation in uterine leiomyomas remains unexplored. In this study, optimised extraction procedures for fibrotic tissues, coupled with high resolution ChIP-sequencing, promoter capture Hi-C, and RNA-sequencing of matched normal myometrium and diseased leiomyoma tissues, are used to provide an integrative analysis of transcriptional dysregulation mechanisms in leiomyomas. Through the characterisation of the first chromatin interactome in uterine leiomyomas, this study demonstrates that modified enhancer architecture is an important mechanism of transcriptional dysregulation in uterine fibroids.Activator protein 1 (AP-1) is a dimeric transcription factor that responds to varied stimuli and is responsible for the regulation of many cellular processes such as proliferation and differentiation. AP-1 subunits belonging to JUN, FOS and ATF gene families have previously been demonstrated to be down regulated in uterine leiomyomas. This study highlights the link between decreased AP-1 subunit gene expression and modifications in leiomyoma tissue enhancer architecture. The loss of AP-1 expression results in the depletion of AP-1 occupancy on chromatin in leiomyoma tissue samples, which correlates with changes in H3K27 acetylation at distal cis-regulatory elements.Importantly, this study also demonstrates that silencing of AP-1 subunits in primary human uterine smooth muscle cells leads to large-scale transcriptional dysregulation. In addition, loss of AP-1 causes significant alteration to the H3K27Ac cistrome in uterine smooth muscle cells, primarily at promoter-distal sites, thereby partially recapitulating epigenetic changes seen in leiomyoma tissue samples. The data supports the hypothesis that AP-1 plays an important mechanistic role in enhancer maintenance and the loss of AP-1 results in altered enhancer architecture in uterine smooth muscle cells. These findings establish AP-1 driven aberrant enhancer regulation as an important mechanism of leiomyoma disease pathogenesis.
- Keyword:
- Reproductive disorders, Epigenomics, Gene regulation, Chromatin structure, Histone post-translational modifications
- Subject: MESH:
- Leiomyoma, Uterine Neoplasms
- Creator:
- Moyo, Mthabisi Bongani
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-06
- Rights:
- http://creativecommons.org/licenses/by-nc-nd/3.0/us/
- Resource Type:
- Academic Dissertations
- Original Identifier:
- (DOI) 10.21985/n2-vsb2-cm32
- Title:
- 2020-2021 Series 08 NUCATS Articulating Your Mentoring Philosophy and Plan
- Description:
- Distinguish between a mentoring plan and a mentoring philosophy. Examine different mentoring experiences. List ~10 mentoring plan behaviors that most matter to you. Propose a mentoring philosophy that is unique to you.
- Keyword:
- Mentoring, NUCATS
- Subject: MESH:
- Mentoring, Mentors--education
- Creator:
- Goodman, Adam
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-06-03
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/3.0/us/
- Resource Type:
- Presentation
- Title:
- Table 12. Incidence by Age Among Females
- Keyword:
- Tables of Prevalence
- Subject: MESH:
- Mentally Ill Persons, Crime Victims, Women, Age Groups
- Creator:
- Lag, Madeline Rose
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Tables
- Title:
- Table 11. Incidence by Age Among Males
- Keyword:
- Tables of Prevalence
- Subject: MESH:
- Mentally Ill Persons, Crime Victims, Men, Age Groups
- Creator:
- Lag, Madeline Rose
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Tables
- Title:
- Table 10. Incidence by Race Among Females
- Keyword:
- Tables of Prevalence
- Subject: MESH:
- Mentally Ill Persons, Crime Victims, Women, Racial Groups
- Creator:
- Lag, Madeline Rose
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Tables
- Title:
- Table 9. Incidence by Race Among Males
- Keyword:
- Tables of Prevalence
- Subject: MESH:
- Mentally Ill Persons, Crime Victims, Men, Racial Groups
- Creator:
- Lag, Madeline Rose
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Tables
- Title:
- Table 8. Incidence by Gender
- Keyword:
- Tables of Prevalence
- Subject: MESH:
- Mentally Ill Persons, Crime Victims
- Creator:
- Lag, Madeline Rose
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Tables
289. Table 7. Incidence
- Title:
- Table 7. Incidence
- Keyword:
- Tables of Prevalence
- Subject: MESH:
- Mentally Ill Persons, Crime Victims
- Creator:
- Lag, Madeline Rose
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Tables
- Title:
- Table 6. Prevalence by Age Among Females
- Keyword:
- Tables of Prevalence
- Subject: MESH:
- Mentally Ill Persons, Crime Victims, Women
- Creator:
- Lag, Madeline Rose
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Tables
- Title:
- Table 5. Prevalence by Age Among Males
- Keyword:
- Tables of Prevalence
- Subject: MESH:
- Mentally Ill Persons, Mental Disorders, Crime Victims, Men
- Creator:
- Lag, Madeline Rose
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Tables
- Title:
- Table 2. Prevalence by Gender
- Keyword:
- Tables of Prevalence
- Subject: MESH:
- Mentally Ill Persons, Crime Victims, Mental Disorders
- Creator:
- Lag, Madeline Rose
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Tables
- Title:
- Table 4. Prevalence by Race Among Females
- Keyword:
- Tables of Prevalence
- Subject: MESH:
- Mentally Ill Persons, Crime Victims, Women, Racial Groups
- Creator:
- Lag, Madeline Rose
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Tables
294. Table 1. Prevalence
- Title:
- Table 1. Prevalence
- Keyword:
- Tables of Prevalence
- Subject: MESH:
- Mentally Ill Persons, Crime Victims, Mental Disorders
- Creator:
- Lag, Madeline Rose
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Tables
- Title:
- Table 3. Prevalence by Race Among Males
- Keyword:
- Tables of Prevalence
- Subject: MESH:
- Mentally Ill Persons, Mental Disorders, Crime Victims, Racial Groups, Men
- Creator:
- Lag, Madeline Rose
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- All rights reserved
- Resource Type:
- Tables
- Title:
- Crime victimization in adults with severe mental illness: comparison with the National Crime Victimization Survey
- Original Bibliographic Citation:
- Teplin, L. A., McClelland, G. M., Abram, K. M., & Weiner, D. A. (2005). Crime victimization in adults with severe mental illness: comparison with the National Crime Victimization Survey. Archives of general psychiatry, 62(8), 911921. https://doi.org/10.1001/archpsyc.62.8.911
- Abstract:
- Context: Since deinstitutionalization, most persons with severe mental illness (SMI) now live in the community, where they are at great risk for crime victimization.Objectives: To determine the prevalence and incidenceof crime victimization among persons with SMIby sex, race/ethnicity, and age, and to compare rates with general population data (the National Crime Victimization Survey), controlling for income and demographic differences between the samples.Design: Epidemiologic study of persons in treatment.Independent masters-level clinical research interviewers administered the National Crime Victimization Survey to randomly selected patients sampled from 16 randomly selected mental health agencies.Setting: Sixteen agencies providing outpatient, day, and residential treatment to persons with SMI in Chicago, Ill.Participants: Randomly selected, stratified sample of936 patients aged 18 or older (483 men, 453 women) who were African American (n=329), non-Hispanic white (n=321), Hispanic (n=270), or other race/ethnicity (n=22). The comparison group comprised 32 449 participants in the National Crime Victimization Survey.Main Outcome Measure: National Crime VictimizationSurvey, developed by the Bureau of Justice Statistics.Results: More than one quarter of persons with SMI had been victims of a violent crime in the past year, a rate more than 11 times higher than the general population rates even after controlling for demographic differences between the 2 samples (P<.001). The annual incidence of violent crime in the SMI sample (168.2 incidents per 1000 persons) is more than 4 times higher than the general population rates (39.9 incidents per 1000 persons) (P<.001). Depending on the type of violent crime (rape/sexual assault, robbery, assault, and their subcategories), prevalence was 6 to 23 times greater among persons with SMI than among the general population.Conclusions: Crime victimization is a major public health problem among persons with SMI who are treated in the community. We recommend directions for future research, propose modifications in public policy, and suggest how the mental health system can respond to reduce victimization and its consequences.
- Keyword:
- Psychiatric Disorders, Public Policy, Crime , Correctional Health, Health Disparities, Juvenile Justice
- Creator:
- Lag, Madeline Rose
- Publisher:
- Archives of General Psychiatry, DigitalHub. Galter Health Sciences Library & Learning Center
- Rights:
- All rights reserved
- Original Identifier:
- https://doi.org/10.1001/archpsyc.62.8.911
- Title:
- Raw instantaneous force-displacement data
- Description:
- Each file contains raw instantaneous force-displacement data for two cycles of loading (compression) from 100 N to 1230 N at a rate of 200 N/S and unloading from 1230 N to 100 N at a rate of 200 N/S. The first cycle is considered a settling cycle and data is analyzed from the second cycle. Tests were conducted using an Instron 8800 hydraulic-driven universal material test system.
- Keyword:
- prosthesis, bench test, characterization
- Subject: MESH:
- Prostheses and Implants, Prosthesis Design
- Creator:
- Major, Matthew Justin
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Dataset
- Title:
- Prosthetic Foot Bench Test Characterization
- Description:
- Bench test characterization of prosthetic feet.
- Keyword:
- bench test, prosthesis, material properties, foot
- Creator:
- Major, Matthew Justin
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Date Created:
- 5/10/2021
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Title:
- Making your data FAIR
- Description:
- Presentation created for a Galter Health Sciences Library & Learning Center class on creating and maintaining FAIR data in the context of a next-generation institutional repository.
- Keyword:
- FAIR data, research data management, data sharing, data repositories
- Subject: MESH:
- Data Curation, Information Dissemination, Information Storage and Retrieval
- Subject: LCSH:
- Institutional repositories, Data curation
- Creator:
- Gonzales, Sara
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2020-05-01
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/3.0/us/
- Resource Type:
- Presentation
- Title:
- A Library-based Data Retrieval and Management Training Program for Clinical Researchers
- Description:
- Presented at the Research Data Alliance 17th Plenary Meeting, April 20-23, 2021 in Edinburgh, Scotland (Virtual).
- Original Bibliographic Citation:
- Carson MB, Gonzales S, Shaw P, Schneider D, Holmes K. A Library-based Data Retrieval and Management Training Program for Clinical Researchers. Research Data Alliance 17th Plenary Meeting; April 20-23; Edinburgh, Scotland (Virtual); 2021.
- Abstract:
- We are developing an end-to-end training program that introduces clinician researchers to clinical database architecture and clinical coding standards, teaches them how to translate their research questions into queries that will allow them to extract data properly, and how to do so in a way that supports transparency and reproducibility while still respecting guidelines for proper data sharing. This work builds on longstanding partnerships with the Northwestern Medicine Enterprise Data Warehouse (NMEDW) through which we promote improved communication and collaboration between data analysts and clinical researchers to make them better partners in research projects. We also provide workflows for preservation and reusability of research reports through our next-generation research data management (RDM) system. Our ultimate goal is to bolster support for our local research community to use clinical research data from the NMEDW and also parlay this experience to develop a blueprint of best practice workflows that could be applied in libraries at other institutions.
- Keyword:
- Data Science, Research Data Management, Clinical Data, Training, Relational Databases
- Subject: MESH:
- Database Management Systems, Data Management, Information Management, Medical Informatics, Biomedical Research
- Creator:
- Carson, Matthew Brandon
- Contributor:
- Gonzales, Sara, Shaw, Pamela L, Schneider, Daniel Handley, Holmes, Kristi
- Publisher:
- DigitalHub. Galter Health Sciences Library & Learning Center
- Language:
- English
- Date Created:
- 2021-04
- Rights:
- http://creativecommons.org/licenses/by/4.0/
- Resource Type:
- Poster