2015 Relaunch as Open Access Pediatric Neurology Briefs
Pediatric Neurology Briefs (PNB) has been published monthly since 1987 as a continuing education service designed to expedite and facilitate review of current medical literature concerning pediatric neurology. In 2015, PNB is relaunched as an open access, peer-reviewed, journal with an expanded editorial board. PNB has a new website and content management system capable of organizing peer-review and providing improved indexing, DOI assignment, and online full-text article view. Digitization of back issues, archiving, and inclusion in PubMed are future goals. The new online open access PNB aims to reach more physicians, researchers, and other healthcare providers with highlights of the latest advances in pediatric neurology and commentaries by specialists in the field.
Brain Diseases, Neurology, Pediatrics, Child Development, Nervous System Diseases
Investigators from the Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago IL and the Yale School of Medicine, New Haven, CT have conducted a prospective cohort study of 613 children with newly diagnosed epilepsy to evaluate the occurrence of complete remission and predictive factors. Of the 613 patients recruited, 516 were followed for greater than 10 years and of those, 328 (63.5%) attained complete remission.
Epidemiology, Epilepsy, Prognosis
Brain Diseases, Neurosurgery, Neurology, Pediatrics, Infant, Nervous System Diseases, Child, Child Development
Nordli, Douglas R., Krueger, Jena M.
DigitalHub. Galter Health Sciences Library, Pediatric Neurology Briefs Publishers
Investigators from Johns Hopkins Hospital, Baltimore, MD, retrospectively reviewed 179 records of patients with Duchenne muscular dystrophy (DMD) evaluated between 1989 and 2012. Diagnosis was confirmed by genetic testing or muscle biopsy, and clinical data were complete in 107 patients.
Investigators from Erlangen, Germany; Calgary, CA; and Kafranbel, Syria, identified mutations in the gene, fatty acyl-CoA reductase 1 (FAR1) deficiency, adding to three other genes involved in plasmalogen biosynthesis, in two families affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity.
Investigators from Danish Headache Centre, Glostrup Hospital, and the University of Copenhagen investigated whether intracellular cyclic AMP accumulation induced migraine attacks among 14 migraine patients without aura.
MRI Features Predictive of Aicardi-Goutieres Syndrome
Investigators from Children's National Health System Washington, DC, USA: Harvard University, Boston, USA; Leeds Teaching Hospitals, UK; and other international centers review a series of patients with MRIs selected from IRB-approved leukodystrophy biorepositories to identify MRI patterns for recognition of early-onset Aicardi-Goutieres (A-G) syndrome and scored for a panel of radiologic predictors.
Atomoxetine/Methylphenidate Effects on Social Play Behavior
Researchers at Utrecht University, The Netherlands, and University Roma Tre, Rome, Italy, studied the neural substrates of the previously identified social play-suppressant effects of methylphenidate (MPH) and atomoxetine, drugs widely used for the treatment of attention-deficit hyperactivity disorder (ADHD).
Social Play Behavior, Habenula, Amygdala, Noradrenaline, Methylphenidate, Prefrontal Cortex
MRI Predicts Outcome After HIE Treated with Hypothermia
Investigators from Children's National Medical Center and George Washington University School of Medicine, Washington, DC, studied the correlation between white matter tract changes and developmental outcomes in a series of infants with hypoxic ischemic encephalopathy (HIE) treated with whole body cooling.
Diffusion Tensor Imaging, Corpus Callosum, Hypothermia, Magnetic Resonance Imaging
Outcome of Cerebellar Injury with Intraventricular Hemorrhage
Investigators from the Department of Pediatric Neurology, Morinomiya Hospital, Osaka, Japan performed a retrospective IRB approved study of the prevalence of cerebellar injury (CI) and effect on functional outcomes among preterm children with intraventricular hemorrhage (IVH) and cerebral palsy (CP), comparing them to infants with post-hemorrhagic hydrocephalus (PH).